Page last updated: 2024-09-27

Isospora Infection

Infection with parasitic protozoa of the genus ISOSPORA, producing intestinal disease. It is caused by ingestion of oocysts and can produce tissue cysts.

Synonyms(2)

Synonym
Isosporiasis
Isospora Infection

Research Excerpts

Overview

ExcerptReference
"Cystoisosporiasis is an intestinal infectious disease caused by a coccidian protozoa, Cystoisospora belli (C."( Andoh, A; Bamba, S; Imai, T; Inatomi, O; Konishi, K; Kushima, R; Ohno, M; Sasaki, M; Takahashi, K, 2021)

Treatment

ExcerptReference
"All patients were treated for isosporiasis, 27 of them with cotrimoxazole."( Carel, O; de Castro, N; Delcey, V; Lagrange-XĂ©lot, M; Magnier, JD; Molina, JM; Porcher, R; Sarfati, C, 2008)

Research

Studies (55)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's1 (1.82)12.5806
2000's27 (49.09)18.1394
2010's21 (38.18)28.8240
2020's6 (10.91)9.53
DrugIndicatedRelationship StrengthStudiesTrials
lactic acid0low10
formaldehyde0low10
albendazole0low10
azathioprine0low10
metronidazole0low10
praziquantel0medium11
pyrimethamine0low10
ronidazole0low10
sulfadiazine0low10
sulfadimethoxine0low10
sulfamethazine0medium32
sulfamethoxazole0low10
tinidazole0low10
trimethoprim0low30
n-vinyl-2-pyrrolidinone0low10
ethyl acetate0low10
thiazoles0low10
eosine yellowish-(ys)0low10
vancomycin0low10
benzophenoneidum0low10
phenyl acetate0low10
cetylpyridinium chloride anhydrous0low10
nitazoxanide0low10
sulfadiazine, trimethoprim drug combination0low10
toltrazuril0medium178
tebuconazole0low10
methotrexate0low10
4,4'-bis(2-di(2-hydroxyethyl)amino-4-(3-sulphophenylamino)-1,3,5-triazine-6-ylamino)stilbene-2,2'-disulphonic acid0low10
trimethoprim, sulfamethoxazole drug combination0low190
diclazuril0medium42
safranine t0low10
bay 44-44000medium33
dextrothyroxine0low10

Protein Targets (335)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Beta-lactamase1001
Luciferase4004
glp-1 receptor, partial5005
hypoxia-inducible factor 1 alpha subunit3003
RAR-related orphan receptor gamma120012
ATAD5 protein, partial4004
Fumarate hydratase4004
TDP1 protein8008
GLI family zinc finger 3110011
AR protein130013
caspase 7, apoptosis-related cysteine protease3003
nuclear receptor subfamily 1, group I, member 39009
progesterone receptor8008
glucocorticoid receptor [Homo sapiens]100010
retinoic acid nuclear receptor alpha variant 1100010
retinoid X nuclear receptor alpha110011
estrogen-related nuclear receptor alpha150015
farnesoid X nuclear receptor8008
pregnane X nuclear receptor110011
estrogen nuclear receptor alpha180018
polyprotein4004
67.9K protein5005
peroxisome proliferator activated receptor gamma100010
vitamin D (1,25- dihydroxyvitamin D3) receptor6006
caspase-33003
IDH14004
euchromatic histone-lysine N-methyltransferase 27007
aryl hydrocarbon receptor6006
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a8008
v-jun sarcoma virus 17 oncogene homolog (avian)6006
nuclear receptor subfamily 1, group I, member 23003
Histone H2A.x7007
cellular tumor antigen p53 isoform a7007
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
chromobox protein homolog 16006
nuclear factor erythroid 2-related factor 2 isoform 23003
transcriptional regulator ERG isoform 34004
thyroid hormone receptor beta isoform 2130013
histone deacetylase 9 isoform 32002
heat shock protein beta-14004
mitogen-activated protein kinase 17007
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
geminin120012
Vif0001
peripheral myelin protein 227007
survival motor neuron protein isoform d9009
muscleblind-like protein 1 isoform 18008
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
lamin isoform A-delta10130013
neuropeptide S receptor isoform A4004
ATP-binding cassette sub-family C member 3010010
Multidrug resistance-associated protein 4010011
Voltage-dependent calcium channel gamma-2 subunit8008
Bile salt export pump013013
Interferon beta6006
Cellular tumor antigen p53130013
Integrin beta-34004
Integrin alpha-IIb4004
Methionine aminopeptidase0101
Glutamate receptor 28008
Fatty-acid amide hydrolase 10101
Inositol monophosphatase 12002
Canalicular multispecific organic anion transporter 1010010
ATPase family AAA domain-containing protein 58008
Ataxin-28008
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, Ferritin light chain4004
interleukin 85005
acetylcholinesterase7007
thioredoxin reductase5005
phosphopantetheinyl transferase3003
SMAD family member 27007
SMAD family member 37007
Microtubule-associated protein tau6006
thioredoxin glutathione reductase2002
EWS/FLI fusion protein7007
G3003
P531001
peroxisome proliferator-activated receptor delta8008
arylsulfatase A2002
thyroid stimulating hormone receptor4004
activating transcription factor 65005
Bloom syndrome protein isoform 15005
peripheral myelin protein 22 isoform 12002
hemoglobin subunit beta2002
nuclear factor erythroid 2-related factor 2 isoform 18008
DNA polymerase iota isoform a (long)3003
cytochrome P450 3A4 isoform 19009
M-phase phosphoprotein 84004
muscarinic acetylcholine receptor M13003
Gamma-aminobutyric acid receptor subunit pi9009
Bile salt export pump0303
HLA class I histocompatibility antigen, B alpha chain 3003
Gamma-aminobutyric acid receptor subunit beta-19009
Gamma-aminobutyric acid receptor subunit delta9009
Gamma-aminobutyric acid receptor subunit gamma-29009
Gamma-aminobutyric acid receptor subunit alpha-59009
Gamma-aminobutyric acid receptor subunit alpha-39009
Gamma-aminobutyric acid receptor subunit gamma-19009
Gamma-aminobutyric acid receptor subunit alpha-29009
Gamma-aminobutyric acid receptor subunit alpha-49009
Gamma-aminobutyric acid receptor subunit gamma-39009
Gamma-aminobutyric acid receptor subunit alpha-69009
Nuclear receptor ROR-gamma5005
Gamma-aminobutyric acid receptor subunit alpha-19009
Gamma-aminobutyric acid receptor subunit beta-39009
Gamma-aminobutyric acid receptor subunit beta-29009
GABA theta subunit9009
Inositol hexakisphosphate kinase 13003
Gamma-aminobutyric acid receptor subunit epsilon9009
Protein-arginine deiminase type-40404
cytochrome P450 2C9, partial3003
Spike glycoprotein8008
15-lipoxygenase, partial2002
pregnane X receptor5005
thyroid stimulating hormone receptor5005
thyrotropin-releasing hormone receptor2002
potassium voltage-gated channel subfamily H member 2 isoform d5005
lethal factor (plasmid)4004
USP1 protein, partial5005
estrogen receptor 2 (ER beta)9009
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
vitamin D3 receptor isoform VDRA5005
nuclear receptor ROR-gamma isoform 12002
Caspase-20011
Chain A, Cruzipain3003
endonuclease IV2002
nonstructural protein 12002
glucocerebrosidase1001
DNA polymerase beta2002
cytochrome P450 family 3 subfamily A polypeptide 46006
cytochrome P450 2D65005
histone acetyltransferase KAT2A isoform 13003
Nuclear receptor subfamily 1 group I member 20011
Polymerase acidic protein0011
Nuclear receptor subfamily 1 group I member 20011
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
aldehyde dehydrogenase 1 family, member A1110011
Procathepsin L0101
Beta-2 adrenergic receptor0101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, 2-oxoglutarate Oxygenase1001
acid sphingomyelinase1001
dopamine D1 receptor2002
ClpP1001
Thymidylate synthase 0101
alpha-galactosidase1001
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
importin subunit beta-1 isoform 11001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
flap endonuclease 11001
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
DNA polymerase kappa isoform 13003
caspase-1 isoform alpha precursor1001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0607
Dihydrofolate reductase0304
Dihydrofolate reductase 0303
Dihydrofolate reductase0303
Dihydrofolate reductase0101
Dihydrofolate reductase0405
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Carbonic anhydrase 20112
Thymidylate synthase0303
Bifunctional dihydrofolate reductase-thymidylate synthase0303
Thymidylate synthase0202
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0303
Thymidylate synthase0202
Dihydrofolate reductase06310
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0505
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0303
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0708
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Solute carrier organic anion transporter family member 1A30001
Dihydrofolate reductase0202
Pteridine reductase 10202
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0304
TAR DNA-binding protein 433003
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60001
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200101
Dihydrofolate reductase 0303
Solute carrier family 22 member 80001
Solute carrier family 22 member 60101
Dihydrofolate reductase0304
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier organic anion transporter family member 1B30001
Solute carrier family 22 member 110001
Broad substrate specificity ATP-binding cassette transporter ABCG20001
ATP-dependent phosphofructokinase2002
Thioredoxin reductase 0101
thyroid hormone receptor beta isoform a1001
Flavodoxin0001
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Lanosterol 14-alpha demethylase0101
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
PPM1D protein2002
hypothetical protein, conserved1001
bromodomain adjacent to zinc finger domain 2B1001
pyruvate kinase1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
NPC intracellular cholesterol transporter 1 precursor1001
huntingtin isoform 21001
pyruvate kinase PKM isoform a1001
ras-related protein Rab-9A1001
Aldo-keto reductase family 1 member B10101
Endothelin receptor type B1001
Endothelin-1 receptor1102
Signal transducer and activator of transcription 30101
Pyruvate-flavodoxin oxidoreductase0101
Anoctamin-10101
regulator of G-protein signaling 41001
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b0011
GALC protein2002
Smad31001
cytochrome P450 2D6 isoform 11001
dual specificity protein phosphatase 30101
low molecular weight phosphotyrosine protein phosphatase isoform c0101
tyrosine-protein phosphatase non-receptor type 22 isoform 10101
streptokinase A precursor0011
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 10101
Solute carrier family 22 member 1 0202
Estrogen receptor0011
Beta-hexosaminidase subunit alpha0102
Beta-hexosaminidase subunit beta0101
Cytochrome P450 2C9 0202
Substance-K receptor0101
Dihydrofolate reductase0202
Low molecular weight phosphotyrosine protein phosphatase0101
Dipeptidyl peptidase 40202
Bifunctional dihydrofolate reductase-thymidylate synthase0202
Trace amine-associated receptor 50022
Estrogen receptor beta0011
Bifunctional dihydrofolate reductase-thymidylate synthase0202
Multidrug and toxin extrusion protein 10101
Glucocorticoid receptor0001
Aurora kinase A0101
Carbonic anhydrase 10101
Carbonic anhydrase 60101
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Rap guanine nucleotide exchange factor 31001
Histamine H2 receptor1001
5-hydroxytryptamine receptor 60202
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
exodeoxyribonuclease V subunit RecD0101
exodeoxyribonuclease V subunit RecB0101
exodeoxyribonuclease V subunit RecC0101
ATP-dependent 6-phosphofructokinase0101
Dihydropteroate synthase0101
Protease 0112
Cytochrome P450 14alpha-demethylase0011
Sterol 14-alpha demethylase0101
Carnitine O-palmitoyltransferase 1, muscle isoform0101
Chain A, Dihydrofolate Reductase0011
Chain A, Dihydrofolate reductase0101
Chain A, dihydrofolate reductase (DHFR)0101
Chain A, Dihydrofolate reductase0101
Chain A, Dihydrofolate reductase0101
NFKB1 protein, partial1001
cytochrome P450 2C19 precursor1001
Dihydrofolate reductase 0102
Dihydrofolate reductase type 10102
Dihydrofolate reductase0101
Dihydrofolate reductase0101
NH(3)-dependent NAD(+) synthetase0101
Dihydrofolate reductase type 1 from Tn40030101
Dipeptidyl peptidase 40101
5-hydroxytryptamine receptor 2B0101
Metabotropic glutamate receptor 50101
5-hydroxytryptamine receptor 70101
Cytochrome P450 2J20101
Mu-type opioid receptor0101
Potassium voltage-gated channel subfamily H member 20101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase 0101
Dihydrofolate reductase 0101
Albumin0011
Alpha-2A adrenergic receptor0101
60 kDa heat shock protein, mitochondrial0101
Alpha-1B adrenergic receptor0101
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Alpha-1D adrenergic receptor0101
Sodium-dependent serotonin transporter0101
Alpha-1A adrenergic receptor0101
10 kDa heat shock protein, mitochondrial0101
D-alanyl-D-alanine dipeptidase0101
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Transporter0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]