metronidazole has been researched along with Anaplastic Astrocytoma in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stewart, DJ | 1 |
| Benoit, B | 1 |
| Richard, MT | 1 |
| Hugenholtz, H | 1 |
| Dennery, J | 1 |
| Russell, N | 1 |
| Peterson, E | 1 |
| Grahovac, Z | 1 |
| Belanger, G | 1 |
| Maroun, JA | 1 |
| Potapov, SL | 1 |
| Karakulov, RK | 1 |
| Kachkov, IA | 1 |
| Pelevina, II | 1 |
| Urtasun, RC | 1 |
| Miller, JD | 1 |
| Frunchak, V | 1 |
| Koziol, D | 1 |
| Band, PR | 1 |
| Chapman, JD | 1 |
| Feldstein, ML | 1 |
1 trial available for metronidazole and Anaplastic Astrocytoma
| Article | Year |
|---|---|
Radiotherapy pilot trials with sensitizers of hypoxic cells: metronidazole in supratentorial glioblastomas.
Topics: Astrocytoma; Humans; Metronidazole | 1977 |
2 other studies available for metronidazole and Anaplastic Astrocytoma
| Article | Year |
|---|---|
Treatment of malignant gliomas in adults with BCNU plus metronidazole.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Carmustine; Female; Gliobl | 1984 |
[Sensitivity of human brain tumors to radiation and to the combined effect of metronidazole and radiation].
Topics: Animals; Astrocytoma; Brain Neoplasms; Ependymoma; Glioma; Hemangioma; Humans; In Vitro Techniques; | 1982 |