metronidazole has been researched along with Actinobacillus Infections in 14 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Actinobacillus Infections: Infections with bacteria of the genus ACTINOBACILLUS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with previously untreated chronic periodontitis and subgingival Actinobacillus actinomycetemcomitans and/or Porphyromonas gingivalis were randomly assigned to subgingival scaling without (control group) or with systemic amoxicillin plus metronidazole and CHX irrigation (test group)." | 5.11 | Adjunctive antimicrobial therapy of periodontitis: long-term effects on disease progression and oral colonization. ( Beikler, T; Ehmke, B; Flemmig, TF; Milian, E; Moter, A, 2005) |
| " actinomycetemcomitans-associated periodontitis during successive non-surgical and adjunctive metronidazole plus amoxicillin (or ciprofloxacin) (AB) therapy." | 3.70 | Eradication of Actinobacillus actinomycetemcomitans from the oral cavity in adult periodontitis. ( Borneff, M; Heinecke, A; Kiencke, C; Knopf, A; Müller, HP; Pohl, S, 1998) |
| "We report a patient with multiple brain abscesses due to infection with A." | 2.47 | Brain abscess associated with Aggregatibacter actinomycetemcomitans: case report and review of literature. ( Engström, LJ; Manson, WL; Mooi-Kokenberg, EA; Rahamat-Langendoen, JC; van Vonderen, MG; van Winkelhoff, AJ, 2011) |
| "Although polymicrobial infections, such as peri-implantitis or periodontitis, were postulated in the literature to be caused by synergistic effects of bacteria, these effects remain unclear looking at antibiotic susceptibility." | 1.37 | Antibiotic susceptibility of cocultures in polymicrobial infections such as peri-implantitis or periodontitis: an in vitro model. ( Al-Nawas, B; d'Hoedt, B; Karbach, J; Mouratidou, A, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (28.57) | 18.2507 |
| 2000's | 7 (50.00) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Buchmann, R | 2 |
| Conrads, G | 1 |
| Sculean, A | 1 |
| Mouratidou, A | 1 |
| Karbach, J | 1 |
| d'Hoedt, B | 1 |
| Al-Nawas, B | 1 |
| Rahamat-Langendoen, JC | 1 |
| van Vonderen, MG | 1 |
| Engström, LJ | 1 |
| Manson, WL | 1 |
| van Winkelhoff, AJ | 4 |
| Mooi-Kokenberg, EA | 1 |
| Mombelli, A | 1 |
| Samaranayake, LP | 1 |
| Ehmke, B | 1 |
| Moter, A | 1 |
| Beikler, T | 1 |
| Milian, E | 1 |
| Flemmig, TF | 1 |
| Stewart, AJ | 1 |
| Mogg, TD | 1 |
| Dykgraaf, S | 1 |
| Dannewitz, B | 1 |
| Pohl, S | 2 |
| Eickholz, P | 1 |
| Kim, TS | 1 |
| Overbeek, BP | 1 |
| Pavicić, MJ | 2 |
| van den Bergh, JP | 1 |
| Ernst, JP | 1 |
| de Graaff, J | 2 |
| Müller, HP | 1 |
| Heinecke, A | 2 |
| Borneff, M | 1 |
| Kiencke, C | 1 |
| Knopf, A | 1 |
| Winkel, EG | 1 |
| van der Velden, U | 1 |
| Müller, RF | 1 |
| Lange, DE | 1 |
| Bodur, A | 1 |
| Bodur, H | 1 |
| Bal, B | 1 |
| Baloş, K | 1 |
2 reviews available for metronidazole and Actinobacillus Infections
| Article | Year |
|---|---|
Brain abscess associated with Aggregatibacter actinomycetemcomitans: case report and review of literature.
Topics: Actinobacillus Infections; Adult; Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Anti | 2011 |
Topical and systemic antibiotics in the management of periodontal diseases.
Topics: Actinobacillus Infections; Administration, Oral; Administration, Topical; Aggregatibacter actinomyce | 2004 |
3 trials available for metronidazole and Actinobacillus Infections
| Article | Year |
|---|---|
Short-term effects of systemic antibiotics during periodontal healing.
Topics: Actinobacillus Infections; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; A | 2010 |
Adjunctive antimicrobial therapy of periodontitis: long-term effects on disease progression and oral colonization.
Topics: Actinobacillus Infections; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents | 2005 |
Additional clinical and microbiological effects of amoxicillin and metronidazole after initial periodontal therapy.
Topics: Actinobacillus Infections; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial | 1998 |
9 other studies available for metronidazole and Actinobacillus Infections
| Article | Year |
|---|---|
Antibiotic susceptibility of cocultures in polymicrobial infections such as peri-implantitis or periodontitis: an in vitro model.
Topics: Acetamides; Actinobacillus Infections; Aggregatibacter actinomycetemcomitans; Amoxicillin; Amoxicill | 2011 |
Actinobacillus pleuritis and peritonitis in a quarter horse mare.
Topics: Actinobacillus; Actinobacillus Infections; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, | 2006 |
Actinobacillus peritonitis in a Warmblood gelding.
Topics: Actinobacillus; Actinobacillus Infections; Animals; Anti-Infective Agents; Anti-Inflammatory Agents, | 2006 |
Clinical and microbiological effects of a combined mechanic-antibiotic therapy in subjects with Actinobacillus actinomycetemcomitans-associated periodontitis.
Topics: Actinobacillus Infections; Adolescent; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Ch | 2007 |
Long-standing bacteremia caused by oral Actinobacillus actinomycetemcomitans in a patient with a pacemaker.
Topics: Actinobacillus Infections; Aggregatibacter actinomycetemcomitans; Amoxicillin; Bacteremia; Drug Ther | 1993 |
Eradication of Actinobacillus actinomycetemcomitans from the oral cavity in adult periodontitis.
Topics: Actinobacillus Infections; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial | 1998 |
Actinobacillus actinomycetemcomitans in destructive periodontal disease. Three-year follow-up results.
Topics: Actinobacillus Infections; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial | 2000 |
Generalized aggressive periodontitis in a prepubertal patient: a case report.
Topics: Actinobacillus Infections; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Alveolar | 2001 |
In vitro susceptibilities of Actinobacillus actinomycetemcomitans to a number of antimicrobial combinations.
Topics: Actinobacillus Infections; Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Drug Intera | 1992 |