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metronidazole and Actinobacillus Infections

metronidazole has been researched along with Actinobacillus Infections in 14 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Actinobacillus Infections: Infections with bacteria of the genus ACTINOBACILLUS.

Research Excerpts

ExcerptRelevanceReference
"Patients with previously untreated chronic periodontitis and subgingival Actinobacillus actinomycetemcomitans and/or Porphyromonas gingivalis were randomly assigned to subgingival scaling without (control group) or with systemic amoxicillin plus metronidazole and CHX irrigation (test group)."5.11Adjunctive antimicrobial therapy of periodontitis: long-term effects on disease progression and oral colonization. ( Beikler, T; Ehmke, B; Flemmig, TF; Milian, E; Moter, A, 2005)
" actinomycetemcomitans-associated periodontitis during successive non-surgical and adjunctive metronidazole plus amoxicillin (or ciprofloxacin) (AB) therapy."3.70Eradication of Actinobacillus actinomycetemcomitans from the oral cavity in adult periodontitis. ( Borneff, M; Heinecke, A; Kiencke, C; Knopf, A; Müller, HP; Pohl, S, 1998)
"We report a patient with multiple brain abscesses due to infection with A."2.47Brain abscess associated with Aggregatibacter actinomycetemcomitans: case report and review of literature. ( Engström, LJ; Manson, WL; Mooi-Kokenberg, EA; Rahamat-Langendoen, JC; van Vonderen, MG; van Winkelhoff, AJ, 2011)
"Although polymicrobial infections, such as peri-implantitis or periodontitis, were postulated in the literature to be caused by synergistic effects of bacteria, these effects remain unclear looking at antibiotic susceptibility."1.37Antibiotic susceptibility of cocultures in polymicrobial infections such as peri-implantitis or periodontitis: an in vitro model. ( Al-Nawas, B; d'Hoedt, B; Karbach, J; Mouratidou, A, 2011)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (28.57)18.2507
2000's7 (50.00)29.6817
2010's3 (21.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Buchmann, R2
Conrads, G1
Sculean, A1
Mouratidou, A1
Karbach, J1
d'Hoedt, B1
Al-Nawas, B1
Rahamat-Langendoen, JC1
van Vonderen, MG1
Engström, LJ1
Manson, WL1
van Winkelhoff, AJ4
Mooi-Kokenberg, EA1
Mombelli, A1
Samaranayake, LP1
Ehmke, B1
Moter, A1
Beikler, T1
Milian, E1
Flemmig, TF1
Stewart, AJ1
Mogg, TD1
Dykgraaf, S1
Dannewitz, B1
Pohl, S2
Eickholz, P1
Kim, TS1
Overbeek, BP1
Pavicić, MJ2
van den Bergh, JP1
Ernst, JP1
de Graaff, J2
Müller, HP1
Heinecke, A2
Borneff, M1
Kiencke, C1
Knopf, A1
Winkel, EG1
van der Velden, U1
Müller, RF1
Lange, DE1
Bodur, A1
Bodur, H1
Bal, B1
Baloş, K1

Reviews

2 reviews available for metronidazole and Actinobacillus Infections

ArticleYear
Brain abscess associated with Aggregatibacter actinomycetemcomitans: case report and review of literature.
    Journal of clinical periodontology, 2011, Volume: 38, Issue:8

    Topics: Actinobacillus Infections; Adult; Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Anti

2011
Topical and systemic antibiotics in the management of periodontal diseases.
    International dental journal, 2004, Volume: 54, Issue:1

    Topics: Actinobacillus Infections; Administration, Oral; Administration, Topical; Aggregatibacter actinomyce

2004

Trials

3 trials available for metronidazole and Actinobacillus Infections

ArticleYear
Short-term effects of systemic antibiotics during periodontal healing.
    Quintessence international (Berlin, Germany : 1985), 2010, Volume: 41, Issue:4

    Topics: Actinobacillus Infections; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; A

2010
Adjunctive antimicrobial therapy of periodontitis: long-term effects on disease progression and oral colonization.
    Journal of periodontology, 2005, Volume: 76, Issue:5

    Topics: Actinobacillus Infections; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents

2005
Additional clinical and microbiological effects of amoxicillin and metronidazole after initial periodontal therapy.
    Journal of clinical periodontology, 1998, Volume: 25, Issue:11 Pt 1

    Topics: Actinobacillus Infections; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial

1998

Other Studies

9 other studies available for metronidazole and Actinobacillus Infections

ArticleYear
Antibiotic susceptibility of cocultures in polymicrobial infections such as peri-implantitis or periodontitis: an in vitro model.
    Journal of periodontology, 2011, Volume: 82, Issue:9

    Topics: Acetamides; Actinobacillus Infections; Aggregatibacter actinomycetemcomitans; Amoxicillin; Amoxicill

2011
Actinobacillus pleuritis and peritonitis in a quarter horse mare.
    The Veterinary clinics of North America. Equine practice, 2006, Volume: 22, Issue:1

    Topics: Actinobacillus; Actinobacillus Infections; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents,

2006
Actinobacillus peritonitis in a Warmblood gelding.
    The Veterinary clinics of North America. Equine practice, 2006, Volume: 22, Issue:1

    Topics: Actinobacillus; Actinobacillus Infections; Animals; Anti-Infective Agents; Anti-Inflammatory Agents,

2006
Clinical and microbiological effects of a combined mechanic-antibiotic therapy in subjects with Actinobacillus actinomycetemcomitans-associated periodontitis.
    American journal of dentistry, 2007, Volume: 20, Issue:3

    Topics: Actinobacillus Infections; Adolescent; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Ch

2007
Long-standing bacteremia caused by oral Actinobacillus actinomycetemcomitans in a patient with a pacemaker.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1993, Volume: 16, Issue:2

    Topics: Actinobacillus Infections; Aggregatibacter actinomycetemcomitans; Amoxicillin; Bacteremia; Drug Ther

1993
Eradication of Actinobacillus actinomycetemcomitans from the oral cavity in adult periodontitis.
    Journal of periodontal research, 1998, Volume: 33, Issue:1

    Topics: Actinobacillus Infections; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial

1998
Actinobacillus actinomycetemcomitans in destructive periodontal disease. Three-year follow-up results.
    Journal of periodontology, 2000, Volume: 71, Issue:3

    Topics: Actinobacillus Infections; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial

2000
Generalized aggressive periodontitis in a prepubertal patient: a case report.
    Quintessence international (Berlin, Germany : 1985), 2001, Volume: 32, Issue:4

    Topics: Actinobacillus Infections; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Alveolar

2001
In vitro susceptibilities of Actinobacillus actinomycetemcomitans to a number of antimicrobial combinations.
    Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:12

    Topics: Actinobacillus Infections; Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Drug Intera

1992