Page last updated: 2024-08-05 12:17:00
thiazolidines
null
ChEBI ID: 35622
Members (8)
| Member | Definition | Role |
|---|---|---|
| 3-(5-cycloheptylidene-4-oxo-2-sulfanylidene-3-thiazolidinyl)propanoic acid | 3-(5-cycloheptylidene-4-oxo-2-sulfanylidene-3-thiazolidinyl)propanoic acid | |
| 5-cyclopentylidene-2-sulfanylidene-4-thiazolidinone | 5-cyclopentylidene-2-sulfanylidene-4-thiazolidinone | |
| epalrestat | A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy. | epalrestat |
| lugdunin | A thiazolidine-containing homodetic cyclic peptide that is isolated from human nasal bacteria. Exhibits bactericidal activity against many major pathogens including methicillin-resistant Staphylococcus aureus (MRSA). | lugdunin |
| n-nitrosothiazolidine | N-nitroso-1,3-thiazolidine | |
| pyochelin | A member of the class of thiazolidines that is (4R)-3-methyl-1,3-thiazolidine-4-carboxylic acid which is substituted at position 2 by a (4R)-2-(2-hydroxyphenyl)-4,5-dihydro-1,3-thiazol-4-yl group. A siderophore that is produced by Pseudomonas aeruginosa (via condensation of salicylic acid and two molecules of cysteine) as a mixture of two easily interconvertible diastereoisomers, pyochelin I (major) and pyochelin II (minor). The enantiomeric compounds, enant-pyochelin, are produced by Pseudomonas fluorescens. | pyochelin |
| thiacloprid | A nitrile that is cyanamide in which the hydrogens are replaced by a 1,3-thiazolidin-2-ylidene group which in turn is substituted by a (6-chloropyridin-3-yl)methyl group at the ring nitrogen. | thiacloprid |
| yersiniabactin | A member of the class of thiazolidines that is (4S)-4-methyl-4,5-dihydro-1,3-thiazole-4-carboxylic acid which is substituted at position 2 by a (1S)-1-hydroxy-1-{(4R)-2-[(4R)-2-(2-hydroxyphenyl)-4,5-dihydro-1,3-thiazol-4-yl]-1,3-thiazolidin-4-yl}-2-methylpropan-2-yl group. A siderophore found in the gram-negative bacterium species, Yersinia enterocolitica and Yersinia pestis. | yersiniabactin |
Research
Studies (807)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 36 (4.46) | 18.7374 |
| 1990's | 92 (11.40) | 18.2507 |
| 2000's | 176 (21.81) | 29.6817 |
| 2010's | 337 (41.76) | 24.3611 |
| 2020's | 166 (20.57) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 23 (2.73%) | 5.53% |
| Reviews | 37 (4.40%) | 6.00% |
| Case Studies | 5 (0.59%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 776 (92.27%) | 84.16% |