metronidazole has been researched along with Nerve Degeneration in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Axon degeneration is a feature of many peripheral neuropathies." | 1.40 | Peripheral glia have a pivotal role in the initial response to axon degeneration of peripheral sensory neurons in zebrafish. ( Pope, HM; Voigt, MM, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Erdener, SE | 1 |
| Kansu, T | 1 |
| Arsava, EM | 1 |
| Dericioglu, N | 1 |
| Pope, HM | 2 |
| Voigt, MM | 2 |
| Cox, JA | 1 |
| Zhang, B | 1 |
3 other studies available for metronidazole and Nerve Degeneration
| Article | Year |
|---|---|
Brain MRI evolution of metronidazole intoxication.
Topics: Corpus Callosum; Female; Humans; Magnetic Resonance Imaging; Metronidazole; Middle Aged; Nerve Degen | 2013 |
Peripheral glia have a pivotal role in the initial response to axon degeneration of peripheral sensory neurons in zebrafish.
Topics: Animals; Animals, Genetically Modified; Axons; Bacterial Proteins; Cell Death; Disease Models, Anima | 2014 |
Transcriptome Analysis of Chemically-Induced Sensory Neuron Ablation in Zebrafish.
Topics: Animals; Cytokines; Denervation; Gene Expression Regulation, Developmental; Larva; Metabolic Network | 2016 |