metronidazole has been researched along with Pyometra in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Pyometra: An accumulation of PUS in the uterine cavity (UTERUS). Pyometra generally indicates the presence of infections.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Septic shock was defined as the presence of severe sepsis plus hypotension not reversed with fluid resuscitation." | 2.77 | Changes in tissue perfusion parameters in dogs with severe sepsis/septic shock in response to goal-directed hemodynamic optimization at admission to ICU and the relation to outcome. ( Conti-Patara, A; Cortopassi, SR; de Araújo Caldeira, J; de Carvalho, Hda S; de Mattos-Junior, E; de Oliveira, CM; Faustino, M; Francisco Talib, MS; Patara, M; Pedron, BG; Reinoldes, A, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bhaskar, MM | 1 |
| Sistla, S | 1 |
| Kumaravel, S | 1 |
| Conti-Patara, A | 1 |
| de Araújo Caldeira, J | 1 |
| de Mattos-Junior, E | 1 |
| de Carvalho, Hda S | 1 |
| Reinoldes, A | 1 |
| Pedron, BG | 1 |
| Patara, M | 1 |
| Francisco Talib, MS | 1 |
| Faustino, M | 1 |
| de Oliveira, CM | 1 |
| Cortopassi, SR | 1 |
1 trial available for metronidazole and Pyometra
| Article | Year |
|---|---|
Changes in tissue perfusion parameters in dogs with severe sepsis/septic shock in response to goal-directed hemodynamic optimization at admission to ICU and the relation to outcome.
Topics: Animals; Anti-Bacterial Agents; Biomarkers; Cephalothin; Dog Diseases; Dogs; Dopamine; Female; Fluid | 2012 |
1 other study available for metronidazole and Pyometra
| Article | Year |
|---|---|
A case of pyometrocolpos with Bifidobacterium species.
Topics: Anti-Bacterial Agents; Bifidobacteriales Infections; Bifidobacterium; Cefoperazone; Child, Preschool | 2017 |