metronidazole has been researched along with Root Resorption in 7 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Root Resorption: Resorption in which cementum or dentin is lost from the root of a tooth owing to cementoclastic or osteoclastic activity in conditions such as trauma of occlusion or neoplasms. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the clinical and radiographic success rates of an antibiotic mix consisting of metronidazole, minocycline and ciprofloxacin (3Mix-MP) and another mix where minocycline was replaced with clindamycin (3Mix-MP-R) in non-instrumentation endodontic treatment (NIET) of necrotic primary molars and to determine the effect of root resorption on the success of the treatment." | 5.24 | Evaluation of antibiotic mix in Non-instrumentation Endodontic Treatment of necrotic primary molars. ( Assfoura, L; Mansour, O; Raslan, N, 2017) |
| "No statistically significant difference is observed between both the groups and a combination of Ciprofloxacin, Minocycline and Tinidazole antibacterial drugs can be used on teeth pulpally involved with physiologic root resorption." | 5.16 | In vivo evaluation of lesion sterilization and tissue repair in primary teeth pulp therapy using two antibiotic drug combinations. ( Anantharaj, A; Jaya, AR; Praveen, P; Rani, PS; Venkataraghavan, K, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 6 (85.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Raslan, N | 1 |
| Mansour, O | 1 |
| Assfoura, L | 1 |
| Jaya, AR | 1 |
| Praveen, P | 1 |
| Anantharaj, A | 1 |
| Venkataraghavan, K | 1 |
| Rani, PS | 1 |
| Asl Aminabadi, N | 1 |
| Satrab, S | 1 |
| Najafpour, E | 1 |
| Samiei, M | 2 |
| Jamali, Z | 2 |
| Shirazi, S | 2 |
| Aminabadi, NA | 1 |
| Huang, B | 1 |
| Agheli, S | 1 |
| da Silva, LA | 1 |
| Nelson-Filho, P | 1 |
| da Silva, RA | 1 |
| Flores, DS | 1 |
| Heilborn, C | 1 |
| Johnson, JD | 1 |
| Cohenca, N | 1 |
| Kargül, B | 1 |
| Tanboga, I | 1 |
| Altinok, B | 1 |
| Beertsen, W | 1 |
| Piscaer, M | 1 |
| Van Winkelhoff, AJ | 1 |
| Everts, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Comparative Clinical and Radiographic Study of 3Mixstatin vs Tri-Antibiotic Mix and Simvastatin in the Treatment of Primary Molars With Inflammatory Root Resorption A Randomized Clinical Trial[NCT03585751] | 45 participants (Anticipated) | Interventional | 2018-09-30 | Not yet recruiting | |||
| A Randomized Controlled Trial Comparing the Clinical and Radiographic Success of 3Mixtatin Versus Modified 3Mix in Lesion Sterilization and Tissue Repair (LSTR) for The Treatment of Necrotic Primary Molars[NCT05677945] | 24 participants (Anticipated) | Interventional | 2023-03-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for metronidazole and Root Resorption
| Article | Year |
|---|---|
Evaluation of antibiotic mix in Non-instrumentation Endodontic Treatment of necrotic primary molars.
Topics: Anti-Bacterial Agents; Child; Ciprofloxacin; Clindamycin; Dental Pulp Necrosis; Drug Combinations; F | 2017 |
In vivo evaluation of lesion sterilization and tissue repair in primary teeth pulp therapy using two antibiotic drug combinations.
Topics: Anti-Bacterial Agents; Child; Ciprofloxacin; Dental Pulp Necrosis; Double-Blind Method; Drug Combina | 2012 |
A randomized trial of direct pulp capping in primary molars using MTA compared to 3Mixtatin: a novel pulp capping biomaterial.
Topics: Aluminum Compounds; Anti-Bacterial Agents; Biocompatible Materials; Calcium Compounds; Chi-Square Di | 2016 |
A Randomized Trial Using 3Mixtatin Compared to MTA in Primary Molars with Inflammatory Root Resorption: A Novel Endodontic Biomaterial.
Topics: Aluminum Compounds; Anti-Bacterial Agents; Calcium Compounds; Cefixime; Child; Child, Preschool; Cip | 2016 |
A Randomized Trial Using 3Mixtatin Compared to MTA in Primary Molars with Inflammatory Root Resorption: A Novel Endodontic Biomaterial.
Topics: Aluminum Compounds; Anti-Bacterial Agents; Calcium Compounds; Cefixime; Child; Child, Preschool; Cip | 2016 |
A Randomized Trial Using 3Mixtatin Compared to MTA in Primary Molars with Inflammatory Root Resorption: A Novel Endodontic Biomaterial.
Topics: Aluminum Compounds; Anti-Bacterial Agents; Calcium Compounds; Cefixime; Child; Child, Preschool; Cip | 2016 |
A Randomized Trial Using 3Mixtatin Compared to MTA in Primary Molars with Inflammatory Root Resorption: A Novel Endodontic Biomaterial.
Topics: Aluminum Compounds; Anti-Bacterial Agents; Calcium Compounds; Cefixime; Child; Child, Preschool; Cip | 2016 |
3 other studies available for metronidazole and Root Resorption
| Article | Year |
|---|---|
Revascularization and periapical repair after endodontic treatment using apical negative pressure irrigation versus conventional irrigation plus triantibiotic intracanal dressing in dogs' teeth with apical periodontitis.
Topics: Alveolar Bone Loss; Alveolar Process; Animals; Anti-Bacterial Agents; Ciprofloxacin; Connective Tiss | 2010 |
Conventional endodontic treatment of primary molars using metronidazole as an intra-canal medicament: a pilot study.
Topics: Abscess; Alveolar Bone Loss; Anti-Infective Agents; Child; Dental Fistula; Dental Pulp Diseases; Fem | 2010 |
Generalized cervical root resorption associated with periodontal disease.
Topics: Acids; Adult; Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial | 2001 |