metronidazole has been researched along with Pulmonary Disease, Chronic Obstructive in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Pulmonary Disease, Chronic Obstructive: A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Colonoscopy revealed a picture of pseudomembranous colitis, and Clostridium difficile toxin was positive." | 1.31 | Pseudomembranous colitis without diarrhea presenting clinically as acute intestinal pseudo-obstruction. ( Pauly, MP; Sheikh, RA; Trudeau, WL; Yasmeen, S, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Boyd, AS | 1 |
| Ortleb, M | 1 |
| Prassler, R | 1 |
| Sheikh, RA | 1 |
| Yasmeen, S | 1 |
| Pauly, MP | 1 |
| Trudeau, WL | 1 |
1 review available for metronidazole and Pulmonary Disease, Chronic Obstructive
| Article | Year |
|---|---|
Vancomycin-associated neutrophilic dermatitis histologically mimicking Cryptococcus.
Topics: Biopsy, Needle; Coronary Artery Disease; Cryptococcus; Dermatomycoses; Diagnosis, Differential; Drug | 2014 |
2 other studies available for metronidazole and Pulmonary Disease, Chronic Obstructive
| Article | Year |
|---|---|
[Percutaneous endoscopic colostomy for treatment of an antibiotic-induced pseudomembranous colitis].
Topics: Anti-Bacterial Agents; Bacterial Toxins; Clostridioides difficile; Colonoscopy; Colostomy; Enterocol | 2008 |
Pseudomembranous colitis without diarrhea presenting clinically as acute intestinal pseudo-obstruction.
Topics: Aged; Anti-Infective Agents; Biopsy; Colonic Pseudo-Obstruction; Colonoscopy; Contrast Media; Diabet | 2001 |