metronidazole has been researched along with Wounds, Penetrating in 6 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Wounds, Penetrating: Wounds caused by objects penetrating the skin.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether a combination of ciprofloxacin hydrochloride and metronidazole hydrochloride would be as effective or more effective than a combination of gentamicin sulfate and metronidazole hydrochloride for preventing infection in patients with penetrating abdominal trauma, to evaluate the factors associated with increased risk of infection, and to determine the serum peak and trough levels of gentamicin with the dosage regimen of 2." | 5.08 | A trial of ciprofloxacin and metronidazole vs gentamicin and metronidazole for penetrating abdominal trauma. ( McCreadie, S; Tyburski, JG; Warsow, KM; Wilson, RF, 1998) |
| "5 g, every 6 hours) were compared with combined gentamicin (80 mg, every 8 hours) and metronidazole (500 mg every 6 hours) therapy in 246 patients hospitalized for penetrating abdominal injuries." | 5.07 | Piperacillin monotherapy compared with metronidazole and gentamicin combination in penetrating abdominal trauma. ( Ganesan, N; Lou, MA; Sims, EH; Thadepalli, H; Williams, SW, 1993) |
| "Successful treatment of tetanus depends on prompt diagnosis of clinical tetanus, treatment to ensure neutralization of circulating toxin and elimination of C." | 2.47 | Narrative review: tetanus-a health threat after natural disasters in developing countries. ( Afshar, M; Ansell, D; Bleck, TP; Raju, M, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Afshar, M | 1 |
| Raju, M | 1 |
| Ansell, D | 1 |
| Bleck, TP | 1 |
| Turnbull, IR | 1 |
| Wlzorek, JJ | 1 |
| Osborne, D | 1 |
| Hotchkiss, RS | 1 |
| Coopersmith, CM | 1 |
| Buchman, TG | 1 |
| Knerlich, F | 1 |
| Verheggen, R | 1 |
| Sims, EH | 2 |
| Lou, MA | 1 |
| Williams, SW | 1 |
| Ganesan, N | 1 |
| Thadepalli, H | 2 |
| Ganesan, K | 1 |
| Mandal, AK | 1 |
| Tyburski, JG | 1 |
| Wilson, RF | 1 |
| Warsow, KM | 1 |
| McCreadie, S | 1 |
1 review available for metronidazole and Wounds, Penetrating
| Article | Year |
|---|---|
Narrative review: tetanus-a health threat after natural disasters in developing countries.
Topics: Anti-Infective Agents; Clostridium tetani; Developing Countries; Disasters; Disease Outbreaks; Endem | 2011 |
3 trials available for metronidazole and Wounds, Penetrating
| Article | Year |
|---|---|
Piperacillin monotherapy compared with metronidazole and gentamicin combination in penetrating abdominal trauma.
Topics: Abdominal Injuries; Adolescent; Adult; Aged; Drug Administration Schedule; Drug Therapy, Combination | 1993 |
How many antibiotics are necessary to treat abdominal trauma victims?
Topics: Abdominal Injuries; Adolescent; Adult; Antibiotic Prophylaxis; Cefoperazone; Ceftriaxone; Cephalospo | 1997 |
A trial of ciprofloxacin and metronidazole vs gentamicin and metronidazole for penetrating abdominal trauma.
Topics: Abdominal Injuries; Adult; Anti-Infective Agents; Ciprofloxacin; Double-Blind Method; Drug Therapy, | 1998 |
2 other studies available for metronidazole and Wounds, Penetrating
| Article | Year |
|---|---|
Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture.
Topics: Age Factors; Aging; Animals; Cecum; Ceftriaxone; Disease Susceptibility; Drug Therapy, Combination; | 2003 |
Neurological picture. Feeding cats might be dangerous: penetrating orbital and brain injury without neurological deficits.
Topics: Aged; Amoxicillin-Potassium Clavulanate Combination; Animals; Antifungal Agents; Brain Injuries; Cat | 2005 |