3-hydroxy-4,3',4',5'-tetramethoxychalcone profile

3-hydroxy-4,3',4',5'-tetramethoxychalcone: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	9884538
CHEMBL ID	9941
SCHEMBL ID	2329679
MeSH ID	M0541831

Synonym
CHEMBL9941 ,
(e)-3-(3''''-hydroxy-4''''-methoxyphenyl)-1-(3'',4'',5''-trimethoxyphenyl)prop-2-en-1-one
3-hydroxy-3'',4,4'',5''-tetramethoxychalcone
3-(3-hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
(e)-3-(3-hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
bdbm50070104
(e)-3-(3-hydroxy-4-methoxy-phenyl)-1-(3,4,5-trimethoxy-phenyl)-propenone
(2e)-3-(3-hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
(e)-3-(3''''-hydroxy-4''''-methoxyphenyl)-1-(3'',4'',5''-trimethoxyphenyl)-2-propen-1-one
SCHEMBL2329679
IKMOZUDCUBMIRL-FNORWQNLSA-N
(e)-1-(3-hydroxy-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)prop-1-en-3-one
07h40ah4na ,
(2e)-3-(3-hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)-2-propen-1-one
3-hydroxy-4,3',4',5'-tetramethoxychalcone
181644-49-5
2-propen-1-one, 3-(3-hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)-, (2e)-
unii-07h40ah4na
AKOS037480490
524945-10-6

Excerpt	Reference	Relevance
"The aim of this study is to synthesize chalcone-polyamine conjugates in order to enhance bioavailability and selectivity of chalcone core towards cancer cells, using polyamine-based vectors."	( Design and multi-step synthesis of chalcone-polyamine conjugates as potent antiproliferative agents. Champavier, Y; Duroux, JL; Fagnère, C; Fidanzi-Dugas, C; Gamond, A; Laurent, A; Léger, DY; Liagre, B; Pinon, A; Pouget, C; Rioux, B; Semaan, J; Sol, V, 2017)	0.46

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Tubulin beta-4A chain	Homo sapiens (human)	IC50 (µMol)	5.6833	0.0005	1.9680	10.0000	AID1595695; AID1597924; AID276376
Tubulin beta chain	Homo sapiens (human)	IC50 (µMol)	5.6833	0.0005	2.0529	10.0000	AID1595695; AID1597924; AID276376
Tubulin alpha-3C chain	Homo sapiens (human)	IC50 (µMol)	5.6833	0.0005	1.9555	10.0000	AID1595695; AID1597924; AID276376
Angiotensin-converting enzyme	Oryctolagus cuniculus (rabbit)	IC50 (µMol)	225.0000	0.0000	1.6129	10.0000	AID464081
Tubulin alpha-1B chain	Homo sapiens (human)	IC50 (µMol)	5.6833	0.0005	1.9555	10.0000	AID1595695; AID1597924; AID276376
Tubulin alpha-4A chain	Homo sapiens (human)	IC50 (µMol)	5.6833	0.0005	1.9555	10.0000	AID1595695; AID1597924; AID276376
Tubulin beta-4B chain	Homo sapiens (human)	IC50 (µMol)	5.6833	0.0005	1.9680	10.0000	AID1595695; AID1597924; AID276376
Tubulin beta-3 chain	Homo sapiens (human)	IC50 (µMol)	5.6833	0.0005	1.8945	10.0000	AID1595695; AID1597924; AID276376
Tubulin beta-2A chain	Homo sapiens (human)	IC50 (µMol)	5.6833	0.0005	1.9680	10.0000	AID1595695; AID1597924; AID276376
Tubulin beta-8 chain	Homo sapiens (human)	IC50 (µMol)	5.6833	0.0005	1.9680	10.0000	AID1595695; AID1597924; AID276376
Tubulin alpha-3E chain	Homo sapiens (human)	IC50 (µMol)	5.6833	0.0005	1.9555	10.0000	AID1595695; AID1597924; AID276376
Tubulin alpha-1A chain	Homo sapiens (human)	IC50 (µMol)	5.6833	0.0005	1.9555	10.0000	AID1595695; AID1597924; AID276376
Tubulin alpha-1C chain	Homo sapiens (human)	IC50 (µMol)	5.6833	0.0005	1.9555	10.0000	AID1595695; AID1597924; AID276376
Tubulin beta-6 chain	Homo sapiens (human)	IC50 (µMol)	5.6833	0.0005	1.9680	10.0000	AID1595695; AID1597924; AID276376
Tubulin beta-2B chain	Homo sapiens (human)	IC50 (µMol)	5.6833	0.0005	1.9680	10.0000	AID1595695; AID1597924; AID276376
Tubulin beta-1 chain	Homo sapiens (human)	IC50 (µMol)	4.4175	0.0005	1.9870	10.0000	AID1595695; AID1597924; AID241105; AID276376
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
negative regulation of microtubule polymerization	Tubulin beta-4A chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin beta-4A chain	Homo sapiens (human)
mitotic cell cycle	Tubulin beta-4A chain	Homo sapiens (human)
odontoblast differentiation	Tubulin beta chain	Homo sapiens (human)
microtubule-based process	Tubulin beta chain	Homo sapiens (human)
cytoskeleton-dependent intracellular transport	Tubulin beta chain	Homo sapiens (human)
natural killer cell mediated cytotoxicity	Tubulin beta chain	Homo sapiens (human)
regulation of synapse organization	Tubulin beta chain	Homo sapiens (human)
spindle assembly	Tubulin beta chain	Homo sapiens (human)
cell division	Tubulin beta chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin beta chain	Homo sapiens (human)
mitotic cell cycle	Tubulin beta chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin alpha-3C chain	Homo sapiens (human)
mitotic cell cycle	Tubulin alpha-3C chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin alpha-1B chain	Homo sapiens (human)
microtubule-based process	Tubulin alpha-1B chain	Homo sapiens (human)
cytoskeleton-dependent intracellular transport	Tubulin alpha-1B chain	Homo sapiens (human)
cell division	Tubulin alpha-1B chain	Homo sapiens (human)
cellular response to interleukin-4	Tubulin alpha-1B chain	Homo sapiens (human)
mitotic cell cycle	Tubulin alpha-1B chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin alpha-4A chain	Homo sapiens (human)
mitotic cell cycle	Tubulin alpha-4A chain	Homo sapiens (human)
natural killer cell mediated cytotoxicity	Tubulin beta-4B chain	Homo sapiens (human)
mitotic cell cycle	Tubulin beta-4B chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin beta-4B chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin beta-3 chain	Homo sapiens (human)
axon guidance	Tubulin beta-3 chain	Homo sapiens (human)
netrin-activated signaling pathway	Tubulin beta-3 chain	Homo sapiens (human)
dorsal root ganglion development	Tubulin beta-3 chain	Homo sapiens (human)
mitotic cell cycle	Tubulin beta-3 chain	Homo sapiens (human)
cerebral cortex development	Tubulin beta-2A chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin beta-2A chain	Homo sapiens (human)
mitotic cell cycle	Tubulin beta-2A chain	Homo sapiens (human)
oocyte maturation	Tubulin beta-8 chain	Homo sapiens (human)
spindle assembly involved in female meiosis	Tubulin beta-8 chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin beta-8 chain	Homo sapiens (human)
mitotic cell cycle	Tubulin beta-8 chain	Homo sapiens (human)
biological_process	Tubulin alpha-3E chain	Homo sapiens (human)
mitotic cell cycle	Tubulin alpha-3E chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin alpha-3E chain	Homo sapiens (human)
neuron migration	Tubulin alpha-1A chain	Homo sapiens (human)
startle response	Tubulin alpha-1A chain	Homo sapiens (human)
intracellular protein transport	Tubulin alpha-1A chain	Homo sapiens (human)
microtubule-based process	Tubulin alpha-1A chain	Homo sapiens (human)
centrosome cycle	Tubulin alpha-1A chain	Homo sapiens (human)
smoothened signaling pathway	Tubulin alpha-1A chain	Homo sapiens (human)
memory	Tubulin alpha-1A chain	Homo sapiens (human)
adult locomotory behavior	Tubulin alpha-1A chain	Homo sapiens (human)
visual learning	Tubulin alpha-1A chain	Homo sapiens (human)
response to mechanical stimulus	Tubulin alpha-1A chain	Homo sapiens (human)
glial cell differentiation	Tubulin alpha-1A chain	Homo sapiens (human)
gene expression	Tubulin alpha-1A chain	Homo sapiens (human)
dentate gyrus development	Tubulin alpha-1A chain	Homo sapiens (human)
cerebellar cortex morphogenesis	Tubulin alpha-1A chain	Homo sapiens (human)
pyramidal neuron differentiation	Tubulin alpha-1A chain	Homo sapiens (human)
cerebral cortex development	Tubulin alpha-1A chain	Homo sapiens (human)
cytoskeleton-dependent intracellular transport	Tubulin alpha-1A chain	Homo sapiens (human)
response to tumor necrosis factor	Tubulin alpha-1A chain	Homo sapiens (human)
locomotory exploration behavior	Tubulin alpha-1A chain	Homo sapiens (human)
microtubule polymerization	Tubulin alpha-1A chain	Homo sapiens (human)
forebrain morphogenesis	Tubulin alpha-1A chain	Homo sapiens (human)
homeostasis of number of cells within a tissue	Tubulin alpha-1A chain	Homo sapiens (human)
regulation of synapse organization	Tubulin alpha-1A chain	Homo sapiens (human)
synapse organization	Tubulin alpha-1A chain	Homo sapiens (human)
cell division	Tubulin alpha-1A chain	Homo sapiens (human)
neuron apoptotic process	Tubulin alpha-1A chain	Homo sapiens (human)
motor behavior	Tubulin alpha-1A chain	Homo sapiens (human)
cellular response to calcium ion	Tubulin alpha-1A chain	Homo sapiens (human)
organelle transport along microtubule	Tubulin alpha-1A chain	Homo sapiens (human)
neuron projection arborization	Tubulin alpha-1A chain	Homo sapiens (human)
response to L-glutamate	Tubulin alpha-1A chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin alpha-1A chain	Homo sapiens (human)
mitotic cell cycle	Tubulin alpha-1A chain	Homo sapiens (human)
microtubule-based process	Tubulin alpha-1C chain	Homo sapiens (human)
cytoskeleton-dependent intracellular transport	Tubulin alpha-1C chain	Homo sapiens (human)
cell division	Tubulin alpha-1C chain	Homo sapiens (human)
mitotic cell cycle	Tubulin alpha-1C chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin alpha-1C chain	Homo sapiens (human)
mitotic cell cycle	Tubulin beta-6 chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin beta-6 chain	Homo sapiens (human)
neuron migration	Tubulin beta-2B chain	Homo sapiens (human)
microtubule-based process	Tubulin beta-2B chain	Homo sapiens (human)
cerebral cortex development	Tubulin beta-2B chain	Homo sapiens (human)
modulation of chemical synaptic transmission	Tubulin beta-2B chain	Homo sapiens (human)
positive regulation of axon guidance	Tubulin beta-2B chain	Homo sapiens (human)
embryonic brain development	Tubulin beta-2B chain	Homo sapiens (human)
mitotic cell cycle	Tubulin beta-2B chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin beta-2B chain	Homo sapiens (human)
platelet formation	Tubulin beta-1 chain	Homo sapiens (human)
thyroid gland development	Tubulin beta-1 chain	Homo sapiens (human)
microtubule polymerization	Tubulin beta-1 chain	Homo sapiens (human)
spindle assembly	Tubulin beta-1 chain	Homo sapiens (human)
thyroid hormone transport	Tubulin beta-1 chain	Homo sapiens (human)
platelet aggregation	Tubulin beta-1 chain	Homo sapiens (human)
mitotic cell cycle	Tubulin beta-1 chain	Homo sapiens (human)
microtubule cytoskeleton organization	Tubulin beta-1 chain	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
GTPase activity	Tubulin beta-4A chain	Homo sapiens (human)
calcium ion binding	Tubulin beta-4A chain	Homo sapiens (human)
protein binding	Tubulin beta-4A chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin beta-4A chain	Homo sapiens (human)
GTP binding	Tubulin beta-4A chain	Homo sapiens (human)
GTPase activity	Tubulin beta chain	Homo sapiens (human)
structural molecule activity	Tubulin beta chain	Homo sapiens (human)
protein binding	Tubulin beta chain	Homo sapiens (human)
protein domain specific binding	Tubulin beta chain	Homo sapiens (human)
ubiquitin protein ligase binding	Tubulin beta chain	Homo sapiens (human)
GTPase activating protein binding	Tubulin beta chain	Homo sapiens (human)
MHC class I protein binding	Tubulin beta chain	Homo sapiens (human)
protein-containing complex binding	Tubulin beta chain	Homo sapiens (human)
metal ion binding	Tubulin beta chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin beta chain	Homo sapiens (human)
GTP binding	Tubulin beta chain	Homo sapiens (human)
hydrolase activity	Tubulin alpha-3C chain	Homo sapiens (human)
metal ion binding	Tubulin alpha-3C chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin alpha-3C chain	Homo sapiens (human)
GTP binding	Tubulin alpha-3C chain	Homo sapiens (human)
double-stranded RNA binding	Tubulin alpha-1B chain	Homo sapiens (human)
GTPase activity	Tubulin alpha-1B chain	Homo sapiens (human)
structural molecule activity	Tubulin alpha-1B chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin alpha-1B chain	Homo sapiens (human)
protein binding	Tubulin alpha-1B chain	Homo sapiens (human)
GTP binding	Tubulin alpha-1B chain	Homo sapiens (human)
ubiquitin protein ligase binding	Tubulin alpha-1B chain	Homo sapiens (human)
protein binding	Tubulin alpha-4A chain	Homo sapiens (human)
hydrolase activity	Tubulin alpha-4A chain	Homo sapiens (human)
protein kinase binding	Tubulin alpha-4A chain	Homo sapiens (human)
metal ion binding	Tubulin alpha-4A chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin alpha-4A chain	Homo sapiens (human)
GTP binding	Tubulin alpha-4A chain	Homo sapiens (human)
double-stranded RNA binding	Tubulin beta-4B chain	Homo sapiens (human)
GTPase activity	Tubulin beta-4B chain	Homo sapiens (human)
protein binding	Tubulin beta-4B chain	Homo sapiens (human)
MHC class I protein binding	Tubulin beta-4B chain	Homo sapiens (human)
metal ion binding	Tubulin beta-4B chain	Homo sapiens (human)
unfolded protein binding	Tubulin beta-4B chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin beta-4B chain	Homo sapiens (human)
GTP binding	Tubulin beta-4B chain	Homo sapiens (human)
GTPase activity	Tubulin beta-3 chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin beta-3 chain	Homo sapiens (human)
protein binding	Tubulin beta-3 chain	Homo sapiens (human)
GTP binding	Tubulin beta-3 chain	Homo sapiens (human)
peptide binding	Tubulin beta-3 chain	Homo sapiens (human)
metal ion binding	Tubulin beta-3 chain	Homo sapiens (human)
netrin receptor binding	Tubulin beta-3 chain	Homo sapiens (human)
GTPase activity	Tubulin beta-2A chain	Homo sapiens (human)
protein binding	Tubulin beta-2A chain	Homo sapiens (human)
metal ion binding	Tubulin beta-2A chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin beta-2A chain	Homo sapiens (human)
GTP binding	Tubulin beta-2A chain	Homo sapiens (human)
molecular_function	Tubulin beta-8 chain	Homo sapiens (human)
GTPase activity	Tubulin beta-8 chain	Homo sapiens (human)
metal ion binding	Tubulin beta-8 chain	Homo sapiens (human)
GTP binding	Tubulin beta-8 chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin beta-8 chain	Homo sapiens (human)
molecular_function	Tubulin alpha-3E chain	Homo sapiens (human)
protein binding	Tubulin alpha-3E chain	Homo sapiens (human)
hydrolase activity	Tubulin alpha-3E chain	Homo sapiens (human)
metal ion binding	Tubulin alpha-3E chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin alpha-3E chain	Homo sapiens (human)
GTP binding	Tubulin alpha-3E chain	Homo sapiens (human)
structural molecule activity	Tubulin alpha-1A chain	Homo sapiens (human)
protein binding	Tubulin alpha-1A chain	Homo sapiens (human)
hydrolase activity	Tubulin alpha-1A chain	Homo sapiens (human)
identical protein binding	Tubulin alpha-1A chain	Homo sapiens (human)
protein-containing complex binding	Tubulin alpha-1A chain	Homo sapiens (human)
metal ion binding	Tubulin alpha-1A chain	Homo sapiens (human)
protein heterodimerization activity	Tubulin alpha-1A chain	Homo sapiens (human)
GTP binding	Tubulin alpha-1A chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin alpha-1A chain	Homo sapiens (human)
structural molecule activity	Tubulin alpha-1C chain	Homo sapiens (human)
protein binding	Tubulin alpha-1C chain	Homo sapiens (human)
hydrolase activity	Tubulin alpha-1C chain	Homo sapiens (human)
metal ion binding	Tubulin alpha-1C chain	Homo sapiens (human)
GTP binding	Tubulin alpha-1C chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin alpha-1C chain	Homo sapiens (human)
molecular_function	Tubulin beta-6 chain	Homo sapiens (human)
GTPase activity	Tubulin beta-6 chain	Homo sapiens (human)
protein binding	Tubulin beta-6 chain	Homo sapiens (human)
metal ion binding	Tubulin beta-6 chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin beta-6 chain	Homo sapiens (human)
GTP binding	Tubulin beta-6 chain	Homo sapiens (human)
GTPase activity	Tubulin beta-2B chain	Homo sapiens (human)
protein binding	Tubulin beta-2B chain	Homo sapiens (human)
metal ion binding	Tubulin beta-2B chain	Homo sapiens (human)
protein heterodimerization activity	Tubulin beta-2B chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin beta-2B chain	Homo sapiens (human)
GTP binding	Tubulin beta-2B chain	Homo sapiens (human)
GTPase activity	Tubulin beta-1 chain	Homo sapiens (human)
metal ion binding	Tubulin beta-1 chain	Homo sapiens (human)
structural constituent of cytoskeleton	Tubulin beta-1 chain	Homo sapiens (human)
GTP binding	Tubulin beta-1 chain	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
nucleus	Tubulin beta-4A chain	Homo sapiens (human)
cytosol	Tubulin beta-4A chain	Homo sapiens (human)
microtubule	Tubulin beta-4A chain	Homo sapiens (human)
axoneme	Tubulin beta-4A chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta-4A chain	Homo sapiens (human)
internode region of axon	Tubulin beta-4A chain	Homo sapiens (human)
neuronal cell body	Tubulin beta-4A chain	Homo sapiens (human)
myelin sheath	Tubulin beta-4A chain	Homo sapiens (human)
intercellular bridge	Tubulin beta-4A chain	Homo sapiens (human)
extracellular exosome	Tubulin beta-4A chain	Homo sapiens (human)
mitotic spindle	Tubulin beta-4A chain	Homo sapiens (human)
microtubule	Tubulin beta-4A chain	Homo sapiens (human)
cytoplasm	Tubulin beta-4A chain	Homo sapiens (human)
extracellular region	Tubulin beta chain	Homo sapiens (human)
nucleus	Tubulin beta chain	Homo sapiens (human)
nuclear envelope lumen	Tubulin beta chain	Homo sapiens (human)
cytoplasm	Tubulin beta chain	Homo sapiens (human)
cytosol	Tubulin beta chain	Homo sapiens (human)
cytoskeleton	Tubulin beta chain	Homo sapiens (human)
microtubule	Tubulin beta chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta chain	Homo sapiens (human)
azurophil granule lumen	Tubulin beta chain	Homo sapiens (human)
cytoplasmic ribonucleoprotein granule	Tubulin beta chain	Homo sapiens (human)
cell body	Tubulin beta chain	Homo sapiens (human)
membrane raft	Tubulin beta chain	Homo sapiens (human)
intercellular bridge	Tubulin beta chain	Homo sapiens (human)
extracellular exosome	Tubulin beta chain	Homo sapiens (human)
mitotic spindle	Tubulin beta chain	Homo sapiens (human)
protein-containing complex	Tubulin beta chain	Homo sapiens (human)
cytoplasm	Tubulin beta chain	Homo sapiens (human)
microtubule	Tubulin beta chain	Homo sapiens (human)
nucleus	Tubulin alpha-3C chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin alpha-3C chain	Homo sapiens (human)
microtubule	Tubulin alpha-3C chain	Homo sapiens (human)
cytoplasm	Tubulin alpha-3C chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin alpha-1B chain	Homo sapiens (human)
microtubule	Tubulin alpha-1B chain	Homo sapiens (human)
cytoplasmic microtubule	Tubulin alpha-1B chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin alpha-1B chain	Homo sapiens (human)
microtubule	Tubulin alpha-1B chain	Homo sapiens (human)
cytoplasm	Tubulin alpha-1B chain	Homo sapiens (human)
extracellular region	Tubulin alpha-4A chain	Homo sapiens (human)
cytosol	Tubulin alpha-4A chain	Homo sapiens (human)
cytoskeleton	Tubulin alpha-4A chain	Homo sapiens (human)
microtubule	Tubulin alpha-4A chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin alpha-4A chain	Homo sapiens (human)
extracellular exosome	Tubulin alpha-4A chain	Homo sapiens (human)
cytoplasm	Tubulin alpha-4A chain	Homo sapiens (human)
microtubule	Tubulin alpha-4A chain	Homo sapiens (human)
extracellular region	Tubulin beta-4B chain	Homo sapiens (human)
nucleus	Tubulin beta-4B chain	Homo sapiens (human)
cytosol	Tubulin beta-4B chain	Homo sapiens (human)
cytoskeleton	Tubulin beta-4B chain	Homo sapiens (human)
microtubule	Tubulin beta-4B chain	Homo sapiens (human)
axonemal microtubule	Tubulin beta-4B chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta-4B chain	Homo sapiens (human)
azurophil granule lumen	Tubulin beta-4B chain	Homo sapiens (human)
intercellular bridge	Tubulin beta-4B chain	Homo sapiens (human)
extracellular exosome	Tubulin beta-4B chain	Homo sapiens (human)
mitotic spindle	Tubulin beta-4B chain	Homo sapiens (human)
extracellular vesicle	Tubulin beta-4B chain	Homo sapiens (human)
microtubule	Tubulin beta-4B chain	Homo sapiens (human)
cytoplasm	Tubulin beta-4B chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta-3 chain	Homo sapiens (human)
nucleus	Tubulin beta-3 chain	Homo sapiens (human)
microtubule	Tubulin beta-3 chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta-3 chain	Homo sapiens (human)
lamellipodium	Tubulin beta-3 chain	Homo sapiens (human)
filopodium	Tubulin beta-3 chain	Homo sapiens (human)
axon	Tubulin beta-3 chain	Homo sapiens (human)
dendrite	Tubulin beta-3 chain	Homo sapiens (human)
growth cone	Tubulin beta-3 chain	Homo sapiens (human)
neuronal cell body	Tubulin beta-3 chain	Homo sapiens (human)
intercellular bridge	Tubulin beta-3 chain	Homo sapiens (human)
extracellular exosome	Tubulin beta-3 chain	Homo sapiens (human)
cell periphery	Tubulin beta-3 chain	Homo sapiens (human)
mitotic spindle	Tubulin beta-3 chain	Homo sapiens (human)
microtubule	Tubulin beta-3 chain	Homo sapiens (human)
cytoplasm	Tubulin beta-3 chain	Homo sapiens (human)
nucleus	Tubulin beta-2A chain	Homo sapiens (human)
microtubule	Tubulin beta-2A chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta-2A chain	Homo sapiens (human)
intercellular bridge	Tubulin beta-2A chain	Homo sapiens (human)
extracellular exosome	Tubulin beta-2A chain	Homo sapiens (human)
mitotic spindle	Tubulin beta-2A chain	Homo sapiens (human)
extracellular vesicle	Tubulin beta-2A chain	Homo sapiens (human)
cytoplasm	Tubulin beta-2A chain	Homo sapiens (human)
microtubule	Tubulin beta-2A chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta-8 chain	Homo sapiens (human)
intercellular bridge	Tubulin beta-8 chain	Homo sapiens (human)
extracellular exosome	Tubulin beta-8 chain	Homo sapiens (human)
mitotic spindle	Tubulin beta-8 chain	Homo sapiens (human)
meiotic spindle	Tubulin beta-8 chain	Homo sapiens (human)
microtubule	Tubulin beta-8 chain	Homo sapiens (human)
cytoplasm	Tubulin beta-8 chain	Homo sapiens (human)
nucleus	Tubulin alpha-3E chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin alpha-3E chain	Homo sapiens (human)
microtubule	Tubulin alpha-3E chain	Homo sapiens (human)
cytoplasm	Tubulin alpha-3E chain	Homo sapiens (human)
condensed chromosome	Tubulin alpha-1A chain	Homo sapiens (human)
nucleus	Tubulin alpha-1A chain	Homo sapiens (human)
cytosol	Tubulin alpha-1A chain	Homo sapiens (human)
microtubule	Tubulin alpha-1A chain	Homo sapiens (human)
axonemal microtubule	Tubulin alpha-1A chain	Homo sapiens (human)
plasma membrane	Tubulin alpha-1A chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin alpha-1A chain	Homo sapiens (human)
neuromuscular junction	Tubulin alpha-1A chain	Homo sapiens (human)
cytoplasmic ribonucleoprotein granule	Tubulin alpha-1A chain	Homo sapiens (human)
recycling endosome	Tubulin alpha-1A chain	Homo sapiens (human)
extracellular exosome	Tubulin alpha-1A chain	Homo sapiens (human)
microtubule	Tubulin alpha-1A chain	Homo sapiens (human)
cytoplasm	Tubulin alpha-1A chain	Homo sapiens (human)
nucleus	Tubulin alpha-1C chain	Homo sapiens (human)
microtubule	Tubulin alpha-1C chain	Homo sapiens (human)
cytoplasmic microtubule	Tubulin alpha-1C chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin alpha-1C chain	Homo sapiens (human)
vesicle	Tubulin alpha-1C chain	Homo sapiens (human)
membrane raft	Tubulin alpha-1C chain	Homo sapiens (human)
microtubule	Tubulin alpha-1C chain	Homo sapiens (human)
cytoplasm	Tubulin alpha-1C chain	Homo sapiens (human)
nucleus	Tubulin beta-6 chain	Homo sapiens (human)
microtubule	Tubulin beta-6 chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta-6 chain	Homo sapiens (human)
intercellular bridge	Tubulin beta-6 chain	Homo sapiens (human)
extracellular exosome	Tubulin beta-6 chain	Homo sapiens (human)
mitotic spindle	Tubulin beta-6 chain	Homo sapiens (human)
cytoplasm	Tubulin beta-6 chain	Homo sapiens (human)
microtubule	Tubulin beta-6 chain	Homo sapiens (human)
nucleus	Tubulin beta-2B chain	Homo sapiens (human)
microtubule	Tubulin beta-2B chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta-2B chain	Homo sapiens (human)
intercellular bridge	Tubulin beta-2B chain	Homo sapiens (human)
mitotic spindle	Tubulin beta-2B chain	Homo sapiens (human)
Schaffer collateral - CA1 synapse	Tubulin beta-2B chain	Homo sapiens (human)
microtubule	Tubulin beta-2B chain	Homo sapiens (human)
cytoplasm	Tubulin beta-2B chain	Homo sapiens (human)
cytoplasm	Tubulin beta-1 chain	Homo sapiens (human)
microtubule cytoskeleton	Tubulin beta-1 chain	Homo sapiens (human)
intercellular bridge	Tubulin beta-1 chain	Homo sapiens (human)
extracellular exosome	Tubulin beta-1 chain	Homo sapiens (human)
mitotic spindle	Tubulin beta-1 chain	Homo sapiens (human)
microtubule	Tubulin beta-1 chain	Homo sapiens (human)
cytoplasm	Tubulin beta-1 chain	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (148)

Assay ID	Title	Year	Journal	Article
AID1534364	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay	2019	Journal of medicinal chemistry, 01-24, Volume: 62, Issue:2	Discovery of Novel Quinoline-Chalcone Derivatives as Potent Antitumor Agents with Microtubule Polymerization Inhibitory Activity.
AID1597929	Antiproliferative activity against human NCI-H226 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	2019	Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18	Anti-tumor activity evaluation of novel tubulin and HDAC dual-targeting inhibitors.
AID665697	Cytotoxicity against human ACHN cells after 48 hrs by MTT assay	2012	Bioorganic & medicinal chemistry, Jun-01, Volume: 20, Issue:11	Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents.
AID411283	Cytotoxicity against human H12.1 cells after 96 hrs by SRB assay	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID411303	Cytotoxicity against human SW1736 cells after 96 hrs by SRB assay	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID549584	Inhibition of tubulin polymerization	2011	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2	Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: Synthesis and biological evaluation.
AID452432	Cell cycle arrest in human K562 cells assessed as accumulation at S phase at 20 nM after 24 hrs by propidium iodide staining-based flow cytometry	2009	Bioorganic & medicinal chemistry, Nov-15, Volume: 17, Issue:22	Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: synthesis and biological evaluation of antivascular activity.
AID411317	Induction of apoptosis in human A2780 cells assessed as increase in cleaved/activated form of caspase 3 at 1 uM after 24 hrs by Western blot analysis	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID1408368	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Discovery of novel vinyl sulfone derivatives as anti-tumor agents with microtubule polymerization inhibitory and vascular disrupting activities.
AID452435	Displacement of [3H]colchicine from tubulin assessed as bound colchicine at 0.05 to 10 mM incubated in dark for 2 hrs by scintillation spectroscopy	2009	Bioorganic & medicinal chemistry, Nov-15, Volume: 17, Issue:22	Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: synthesis and biological evaluation of antivascular activity.
AID1534362	Antiproliferative activity against human KB cells after 72 hrs by MTT assay	2019	Journal of medicinal chemistry, 01-24, Volume: 62, Issue:2	Discovery of Novel Quinoline-Chalcone Derivatives as Potent Antitumor Agents with Microtubule Polymerization Inhibitory Activity.
AID411289	Cytotoxicity against human DLD1 cells after 96 hrs by SRB assay	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID411310	Induction of apoptosis in human HL60 cells assessed as processing of procaspase 9 to activated caspase 9 at 10 uM by Western blotting	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID464081	Inhibition of ACE in rabbit lung assessed as decrease in dansylglycine concentration after 5 mins by HPLC analysis	2010	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 20, Issue:6	The synthesis and angiotensin converting enzyme (ACE) inhibitory activity of chalcones and their pyrazole derivatives.
AID411312	Induction of apoptosis in human 518A2 cells assessed as PARP cleavage at 1 uM after 24 hrs by Western blot analysis	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID412468	Induction of apoptosis in human HL60 cells assessed as fold activation of caspase 3/7 at 100 nM	2009	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 19, Issue:1	Synthesis and biological evaluation of a series of tangeretin-derived chalcones.
AID411305	Suppression of regrowth in human A431 cells at 10 nM treated for 96 hrs and measured over 10 days by SRB assay	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID1689068	Anticancer activity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Mar-01, Volume: 189	Dual-functional conjugates improving cancer immunochemotherapy by inhibiting tubulin polymerization and indoleamine-2,3-dioxygenase.
AID411302	Cytotoxicity against human 8505C cells after 96 hrs by SRB assay	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID502775	Antibacterial activity against Helicobacter pylori ATCC 700392 at 0.5 ug/ml by disk agar diffusion method	2010	Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18	Identification of 3',4',5'-trimethoxychalcone analogues as potent inhibitors of Helicobacter pylori-induced inflammation in human gastric epithelial cells.
AID1388217	Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay	2017	Bioorganic & medicinal chemistry letters, 09-15, Volume: 27, Issue:18	Design and multi-step synthesis of chalcone-polyamine conjugates as potent antiproliferative agents.
AID411300	Cytotoxicity against human A2780 cells after 96 hrs by SRB assay	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID1388213	1-octanol/water partition coefficient, log P of the compound at 300 uM by UV-Vis spectrophotometric analysis	2017	Bioorganic & medicinal chemistry letters, 09-15, Volume: 27, Issue:18	Design and multi-step synthesis of chalcone-polyamine conjugates as potent antiproliferative agents.
AID1597939	Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	2019	Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18	Anti-tumor activity evaluation of novel tubulin and HDAC dual-targeting inhibitors.
AID1597925	Antiproliferative activity against human LoVo cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	2019	Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18	Anti-tumor activity evaluation of novel tubulin and HDAC dual-targeting inhibitors.
AID1597940	Antiproliferative activity against human MGC803 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	2019	Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18	Anti-tumor activity evaluation of novel tubulin and HDAC dual-targeting inhibitors.
AID1597933	Antiproliferative activity against human HeLa cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	2019	Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18	Anti-tumor activity evaluation of novel tubulin and HDAC dual-targeting inhibitors.
AID1597938	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	2019	Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18	Anti-tumor activity evaluation of novel tubulin and HDAC dual-targeting inhibitors.
AID453127	Growth inhibition of human HepG2 cells after 48 hrs by MTT assay	2009	Bioorganic & medicinal chemistry, Dec-01, Volume: 17, Issue:23	Synthesis and biological evaluation of 3',4',5'-trimethoxychalcone analogues as inhibitors of nitric oxide production and tumor cell proliferation.
AID1597934	Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	2019	Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18	Anti-tumor activity evaluation of novel tubulin and HDAC dual-targeting inhibitors.
AID411311	Induction of apoptosis in human 518A2 cells assessed as increase in cleaved/activated form of caspase 3 at 1 uM after 24 hrs by Western blot analysis	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID411316	Induction of apoptosis in human WW070327 cells assessed as PARP cleavage at 1 uM after 24 hrs by Western blot analysis	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID1689069	Anticancer activity against human PC3 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Mar-01, Volume: 189	Dual-functional conjugates improving cancer immunochemotherapy by inhibiting tubulin polymerization and indoleamine-2,3-dioxygenase.
AID665823	Inhibition of tubulin polymerization after 1 hr by fluorescence assay	2012	Bioorganic & medicinal chemistry, Jun-01, Volume: 20, Issue:11	Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents.
AID1595691	Antiproliferative activity against human HCT8 cells assessed as reduction in cell viability after 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Jul-01, Volume: 173	Design, synthesis and biological evaluation of pyridine-chalcone derivatives as novel microtubule-destabilizing agents.
AID1595697	Inhibition of [3H]colchicine binding to biotinylated porcine tubulin at 5 uM in presence of GTP after 2 hrs by scintillation proximity assay relative to control	2019	European journal of medicinal chemistry, Jul-01, Volume: 173	Design, synthesis and biological evaluation of pyridine-chalcone derivatives as novel microtubule-destabilizing agents.
AID411314	Induction of apoptosis in human DLD1 cells assessed as PARP cleavage at 1 uM after 24 hrs by Western blot analysis	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID665816	Cell cycle arrest in human A549 cells assessed as cell accumulation at G0/G1 phase at 2 uM after 48 hrs by propidium iodide staining based flow cytometry (Rvb = 70.15%)	2012	Bioorganic & medicinal chemistry, Jun-01, Volume: 20, Issue:11	Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents.
AID461022	Antiproliferative activity against human MCF7 cells after 24 hrs by SRB assay	2010	Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2	A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent.
AID461025	Inhibition of tubulin in rat A10 cells assessed as induction of cellular microtubule disassembly after 18 hrs by indirect immunofluorescence technique	2010	Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2	A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent.
AID443508	Anticancer activity against human NCI-H2009 cells xenografted in SCID mouse assessed as suppression of tumor growth at 1 mg/day, ip treated 6 days in a week for 5 weeks	2009	Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22	Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities.
AID1595690	Antiproliferative activity against human KB cells assessed as reduction in cell viability after 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Jul-01, Volume: 173	Design, synthesis and biological evaluation of pyridine-chalcone derivatives as novel microtubule-destabilizing agents.
AID1595695	Inhibition of tubulin polymerization (unknown origin) in presence of GTP measured after 60 mins by spectrophotometric method	2019	European journal of medicinal chemistry, Jul-01, Volume: 173	Design, synthesis and biological evaluation of pyridine-chalcone derivatives as novel microtubule-destabilizing agents.
AID443507	Toxicity in SCID mouse xenografted with human NCI-H2009 cells assessed as necropsy at 1 mg/day, ip treated 6 days in a week for 5 weeks	2009	Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22	Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities.
AID411293	Cytotoxicity against human NCI-H322 cells after 96 hrs by SRB assay	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID1646994	Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Feb-01, Volume: 187	Microtubule inhibitors containing immunostimulatory agents promote cancer immunochemotherapy by inhibiting tubulin polymerization and tryptophan-2,3-dioxygenase.
AID1408366	Antiproliferative activity against human K562 cells after 72 hrs by MTT assay	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Discovery of novel vinyl sulfone derivatives as anti-tumor agents with microtubule polymerization inhibitory and vascular disrupting activities.
AID411290	Cytotoxicity against human SW480 cells after 96 hrs by SRB assay	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID411295	Cytotoxicity against human FADU cells after 96 hrs by SRB assay	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID665814	Cell cycle arrest in human A549 cells assessed as cell accumulation at subG1 phase at 2 uM after 48 hrs by propidium iodide staining based flow cytometry (Rvb = 1.09%)	2012	Bioorganic & medicinal chemistry, Jun-01, Volume: 20, Issue:11	Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents.
AID1595696	Inhibition of [3H]colchicine binding to biotinylated porcine tubulin at 1 uM in presence of GTP after 2 hrs by scintillation proximity assay relative to control	2019	European journal of medicinal chemistry, Jul-01, Volume: 173	Design, synthesis and biological evaluation of pyridine-chalcone derivatives as novel microtubule-destabilizing agents.
AID452612	Antivascular activity in HUVEC cells assessed as change in cell shape at 1 uM after 1 hr by fluorescent-labeled high molecular weight F-dextran permeability assay	2009	Bioorganic & medicinal chemistry, Nov-15, Volume: 17, Issue:22	Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: synthesis and biological evaluation of antivascular activity.
AID411284	Cytotoxicity against human 2102EP cells after 96 hrs by SRB assay	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID412466	Antiproliferative activity against human KB cells after 72 hrs by MTS assay	2009	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 19, Issue:1	Synthesis and biological evaluation of a series of tangeretin-derived chalcones.
AID1689065	Cytotoxicity against HUVEC cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Mar-01, Volume: 189	Dual-functional conjugates improving cancer immunochemotherapy by inhibiting tubulin polymerization and indoleamine-2,3-dioxygenase.
AID411297	Cytotoxicity against human A431 cells after 96 hrs by SRB assay	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID412472	Antileishmanial activity against Leishmania amazonensis LV9 (MPROB/PR/1972/M1841) amastigotes infected in mouse macrophage after 30 hrs by MTT assay	2009	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 19, Issue:1	Synthesis and biological evaluation of a series of tangeretin-derived chalcones.
AID411306	Suppression of regrowth in human A2780 cells at 10 nM treated for 96 hrs and measured over 10 days by SRB assay	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID411304	Suppression of regrowth in human A253 cells at 10 nM treated for 96 hrs and measured over 10 days by SRB assay	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID1646995	Antiproliferative activity against human A549 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Feb-01, Volume: 187	Microtubule inhibitors containing immunostimulatory agents promote cancer immunochemotherapy by inhibiting tubulin polymerization and tryptophan-2,3-dioxygenase.
AID411285	Cytotoxicity against human 1411HP cells after 96 hrs by SRB assay	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID1646993	Antiproliferative activity against human U87 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Feb-01, Volume: 187	Microtubule inhibitors containing immunostimulatory agents promote cancer immunochemotherapy by inhibiting tubulin polymerization and tryptophan-2,3-dioxygenase.
AID452433	Cell cycle arrest in human K562 cells assessed as accumulation at G2/M phase at 20 nM after 24 hrs by propidium iodide staining-based flow cytometry	2009	Bioorganic & medicinal chemistry, Nov-15, Volume: 17, Issue:22	Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: synthesis and biological evaluation of antivascular activity.
AID411298	Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID411292	Cytotoxicity against human A427 cells after 96 hrs by SRB assay	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID549582	Cytotoxicity against human SH-SY5Y cells after 48 hrs by MTT assay	2011	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2	Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: Synthesis and biological evaluation.
AID665825	Induction of apoptosis in human A549 cells assessed as increase in caspase3 activity using AFC-conjugated Ac-DEVD as substrate at 2 uM after 48 hrs by fluorescence assay relative to control	2012	Bioorganic & medicinal chemistry, Jun-01, Volume: 20, Issue:11	Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents.
AID549585	Cell cycle arrest in human SH-SY5Y cells assessed as accumulation at G0/G1 phase at 2 times IC50 concentration after 16 hrs by FACS analysis (Rvb = 49 +/- 5.5%)	2011	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2	Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: Synthesis and biological evaluation.
AID1408369	Inhibition of porcine brain tubulin polymerization after 30 mins by spectrophotometric method	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Discovery of novel vinyl sulfone derivatives as anti-tumor agents with microtubule polymerization inhibitory and vascular disrupting activities.
AID1388214	Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay	2017	Bioorganic & medicinal chemistry letters, 09-15, Volume: 27, Issue:18	Design and multi-step synthesis of chalcone-polyamine conjugates as potent antiproliferative agents.
AID452610	Inhibition of tubulin polymerization assessed as appearance of twisted and shorter tubulin by electron microscopy	2009	Bioorganic & medicinal chemistry, Nov-15, Volume: 17, Issue:22	Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: synthesis and biological evaluation of antivascular activity.
AID411318	Induction of apoptosis in human A2780 cells assessed as PARP cleavage at 1 uM after 24 hrs by Western blot analysis	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID461023	Inhibition of tubulin polymerization by turbidimetry	2010	Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2	A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent.
AID1646996	Antiproliferative activity against human HCT116 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Feb-01, Volume: 187	Microtubule inhibitors containing immunostimulatory agents promote cancer immunochemotherapy by inhibiting tubulin polymerization and tryptophan-2,3-dioxygenase.
AID443503	Cytotoxicity against human NCI-H2009 cells after 48 hrs by fluorescence assay	2009	Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22	Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities.
AID241105	Concentration required for 50% inhibition of tubulin polymerization	2005	Journal of medicinal chemistry, Jan-27, Volume: 48, Issue:2	Quantitative structure-activity relationship (5D-QSAR) study of combretastatin-like analogues as inhibitors of tubulin assembly.
AID665694	Cytotoxicity against human A375 cells after 48 hrs by MTT assay	2012	Bioorganic & medicinal chemistry, Jun-01, Volume: 20, Issue:11	Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents.
AID372907	Antibacterial activity against Staphylococcus aureus Rosenbach 209 after 48 hrs by agar well diffusion method	2009	European journal of medicinal chemistry, May, Volume: 44, Issue:5	Examination of growth inhibitory properties of synthetic chalcones for which antibacterial activity was predicted.
AID1689067	Anticancer activity against human HeLa cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Mar-01, Volume: 189	Dual-functional conjugates improving cancer immunochemotherapy by inhibiting tubulin polymerization and indoleamine-2,3-dioxygenase.
AID411294	Cytotoxicity against human NCI-H358 cells after 96 hrs by SRB assay	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID453129	Inhibition of nitric oxide production in LPS/IFN-gamma-stimulated BALB/c mouse peritoneal macrophages by Griess method	2009	Bioorganic & medicinal chemistry, Dec-01, Volume: 17, Issue:23	Synthesis and biological evaluation of 3',4',5'-trimethoxychalcone analogues as inhibitors of nitric oxide production and tumor cell proliferation.
AID461027	Inhibition of tubulin in rat A10 cells assessed as disappearance of microtubule network at 20 uM after 18 hrs by fluorescence microscopy	2010	Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2	A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent.
AID411301	Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID1595692	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Jul-01, Volume: 173	Design, synthesis and biological evaluation of pyridine-chalcone derivatives as novel microtubule-destabilizing agents.
AID665820	Cell cycle arrest in human A549 cells assessed as cell accumulation at G2/M phase at 2 uM after 48 hrs by propidium iodide staining based flow cytometry (Rvb = 23.75%)	2012	Bioorganic & medicinal chemistry, Jun-01, Volume: 20, Issue:11	Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents.
AID443496	Inhibition of TNFalpha induced NF-kappaB activation in human A549 cells by luciferase reporter gene assay	2009	Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22	Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities.
AID1534363	Antiproliferative activity against human HCT8 cells after 72 hrs by MTT assay	2019	Journal of medicinal chemistry, 01-24, Volume: 62, Issue:2	Discovery of Novel Quinoline-Chalcone Derivatives as Potent Antitumor Agents with Microtubule Polymerization Inhibitory Activity.
AID443500	Inhibition of IRAK1 at 10 uM	2009	Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22	Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities.
AID372908	Antibacterial activity against Staphylococcus aureus Rosenbach 209 after 24 hrs by serial dilution method	2009	European journal of medicinal chemistry, May, Volume: 44, Issue:5	Examination of growth inhibitory properties of synthetic chalcones for which antibacterial activity was predicted.
AID94656	Compound was evaluated for cytotoxic activity against K562 human chronic myelogenous leukemia cell line using MTT assay	1998	Bioorganic & medicinal chemistry letters, May-05, Volume: 8, Issue:9	Potent antimitotic and cell growth inhibitory properties of substituted chalcones.
AID1388216	Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay	2017	Bioorganic & medicinal chemistry letters, 09-15, Volume: 27, Issue:18	Design and multi-step synthesis of chalcone-polyamine conjugates as potent antiproliferative agents.
AID549583	Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 10 uM after 48 hrs by MTT assay relative to control	2011	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2	Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: Synthesis and biological evaluation.
AID276376	Inhibition of tubulin	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Effects of alpha-substitutions on structure and biological activity of anticancer chalcones.
AID412471	Antileishmanial activity against Leishmania donovani MHOM/ET/1967/HU3 (LV9) promastigotes after 72 hrs by MTT assay	2009	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 19, Issue:1	Synthesis and biological evaluation of a series of tangeretin-derived chalcones.
AID412475	Inhibition of tubulin assembly	2009	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 19, Issue:1	Synthesis and biological evaluation of a series of tangeretin-derived chalcones.
AID549587	Cell cycle arrest in human SH-SY5Y cells assessed as accumulation at G2/M phase at 2 times IC50 concentration after 16 hrs by FACS analysis (Rvb = 15 +/- 4.8%)	2011	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2	Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: Synthesis and biological evaluation.
AID411313	Induction of apoptosis in human DLD1 cells assessed as increase in cleaved/activated form of caspase 3 at 1 uM after 24 hrs by Western blot analysis	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID452430	Antiproliferative activity against human K562 cells after 5 days by MTT assay	2009	Bioorganic & medicinal chemistry, Nov-15, Volume: 17, Issue:22	Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: synthesis and biological evaluation of antivascular activity.
AID443502	Inhibition of TAK1 at 10 uM	2009	Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22	Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities.
AID411291	Cytotoxicity against human A549 cells after 96 hrs by SRB assay	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID411299	Cytotoxicity against human BT474 cells after 96 hrs by SRB assay	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID549586	Cell cycle arrest in human SH-SY5Y cells assessed as accumulation at S phase at 2 times IC50 concentration after 16 hrs by FACS analysis (Rvb = 36 +/- 4%)	2011	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2	Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: Synthesis and biological evaluation.
AID1597941	Antiproliferative activity against human BGC823 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	2019	Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18	Anti-tumor activity evaluation of novel tubulin and HDAC dual-targeting inhibitors.
AID665822	Inhibition of tubulin polymerization at 3 uM after 1 hr by fluorescence assay	2012	Bioorganic & medicinal chemistry, Jun-01, Volume: 20, Issue:11	Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents.
AID443506	Toxicity in SCID mouse xenografted with human NCI-H2009 cells assessed as increase in body weight at 1 mg/day, ip treated 6 days in a week for 5 weeks	2009	Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22	Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities.
AID665696	Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay	2012	Bioorganic & medicinal chemistry, Jun-01, Volume: 20, Issue:11	Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents.
AID665818	Cell cycle arrest in human A549 cells assessed as cell accumulation at S phase at 2 uM after 48 hrs by propidium iodide staining based flow cytometry (Rvb = 5.01%)	2012	Bioorganic & medicinal chemistry, Jun-01, Volume: 20, Issue:11	Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents.
AID411288	Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID1534360	Antiproliferative activity against human K562 cells after 72 hrs by MTT assay	2019	Journal of medicinal chemistry, 01-24, Volume: 62, Issue:2	Discovery of Novel Quinoline-Chalcone Derivatives as Potent Antitumor Agents with Microtubule Polymerization Inhibitory Activity.
AID411296	Cytotoxicity against human A253 cells after 96 hrs by SRB assay	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID1534361	Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay	2019	Journal of medicinal chemistry, 01-24, Volume: 62, Issue:2	Discovery of Novel Quinoline-Chalcone Derivatives as Potent Antitumor Agents with Microtubule Polymerization Inhibitory Activity.
AID411315	Induction of apoptosis in human WW070327 cells assessed as increase in cleaved/activated form of caspase 3 at 1 uM after 24 hrs by Western blot analysis	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID1388215	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	2017	Bioorganic & medicinal chemistry letters, 09-15, Volume: 27, Issue:18	Design and multi-step synthesis of chalcone-polyamine conjugates as potent antiproliferative agents.
AID461024	Displacement of [3H]colchicine from tubulin at 50 uM by turbidimetry	2010	Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2	A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent.
AID412467	Growth inhibition of human KB cells at 6 to 10 M after 72 hrs by MTS assay	2009	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 19, Issue:1	Synthesis and biological evaluation of a series of tangeretin-derived chalcones.
AID443499	Inhibition of IKK-beta at 10 uM	2009	Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22	Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities.
AID1595688	Antiproliferative activity against human K562 cells assessed as reduction in cell viability after 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Jul-01, Volume: 173	Design, synthesis and biological evaluation of pyridine-chalcone derivatives as novel microtubule-destabilizing agents.
AID452431	Cell cycle arrest in human K562 cells assessed as accumulation at G0/G1 phase at 20 nM after 24 hrs by propidium iodide staining-based flow cytometry	2009	Bioorganic & medicinal chemistry, Nov-15, Volume: 17, Issue:22	Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: synthesis and biological evaluation of antivascular activity.
AID411308	Induction of apoptosis in human HL60 cells at 10 uM after 15 hrs by TUNEL assay	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID443501	Inhibition of IRAK4 at 10 uM	2009	Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22	Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities.
AID443497	Inhibition of c-Src at 10 uM	2009	Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22	Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities.
AID411309	Induction of apoptosis in human 518A2 cells at 10 uM after 15 hrs by TUNEL assay	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID412470	Inhibition of tubulin assembly assessed as ratio of IC50 for drug to IC50 for deoxypodophyllotoxin	2009	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 19, Issue:1	Synthesis and biological evaluation of a series of tangeretin-derived chalcones.
AID411319	Inhibition of tubulin polymerization at 3 uM	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID443498	Inhibition of IKKalpha at 10 uM	2009	Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22	Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities.
AID453128	Growth inhibition of human COLO205 cells after 48 hrs by MTT assay	2009	Bioorganic & medicinal chemistry, Dec-01, Volume: 17, Issue:23	Synthesis and biological evaluation of 3',4',5'-trimethoxychalcone analogues as inhibitors of nitric oxide production and tumor cell proliferation.
AID443504	Cytotoxicity against human A549 cells after 48 hrs by fluorescence assay	2009	Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22	Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities.
AID1595689	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Jul-01, Volume: 173	Design, synthesis and biological evaluation of pyridine-chalcone derivatives as novel microtubule-destabilizing agents.
AID276375	Cytotoxicity against human K562 cells after 5 days by MTT assay	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Effects of alpha-substitutions on structure and biological activity of anticancer chalcones.
AID1646997	Cytotoxicity against human LO2 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Feb-01, Volume: 187	Microtubule inhibitors containing immunostimulatory agents promote cancer immunochemotherapy by inhibiting tubulin polymerization and tryptophan-2,3-dioxygenase.
AID452434	Inhibition of tubulin assembly by Woods method	2009	Bioorganic & medicinal chemistry, Nov-15, Volume: 17, Issue:22	Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: synthesis and biological evaluation of antivascular activity.
AID1408367	Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay	2018	European journal of medicinal chemistry, Sep-05, Volume: 157	Discovery of novel vinyl sulfone derivatives as anti-tumor agents with microtubule polymerization inhibitory and vascular disrupting activities.
AID1597924	Inhibition of tubulin polymerization (unknown origin) by spectrophotometric method	2019	Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18	Anti-tumor activity evaluation of novel tubulin and HDAC dual-targeting inhibitors.
AID372906	Antibacterial activity against Escherichia coli WF+	2009	European journal of medicinal chemistry, May, Volume: 44, Issue:5	Examination of growth inhibitory properties of synthetic chalcones for which antibacterial activity was predicted.
AID461021	Displacement of [3H]colchicine from tubulin at 5 uM by turbidimetry	2010	Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2	A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent.
AID1595694	Cytotoxicity against human LO2 cells assessed as reduction in cell viability after 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Jul-01, Volume: 173	Design, synthesis and biological evaluation of pyridine-chalcone derivatives as novel microtubule-destabilizing agents.
AID411286	Cytotoxicity against human HCT8 cells after 96 hrs by SRB assay	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID443505	Toxicity in SCID mouse xenografted with human NCI-H2009 cells at 1 mg/day, ip treated 6 days in a week for 5 weeks	2009	Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22	Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities.
AID665695	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	2012	Bioorganic & medicinal chemistry, Jun-01, Volume: 20, Issue:11	Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents.
AID411307	Binding affinity to Escherichia coli pBR322 DNA assessed as effect on DNA electrophoretic mobility	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID1597936	Antiproliferative activity against human HCT116 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	2019	Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18	Anti-tumor activity evaluation of novel tubulin and HDAC dual-targeting inhibitors.
AID665693	Cytotoxicity against human A549 cells after 48 hrs by MTT assay	2012	Bioorganic & medicinal chemistry, Jun-01, Volume: 20, Issue:11	Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents.
AID411287	Cytotoxicity against human HCT116 cells after 96 hrs by SRB assay	2009	Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2	Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression.
AID1597937	Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	2019	Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18	Anti-tumor activity evaluation of novel tubulin and HDAC dual-targeting inhibitors.
AID1534406	Aqueous solubility in pH 7.4 phosphate buffer by HPLC analysis	2019	Journal of medicinal chemistry, 01-24, Volume: 62, Issue:2	Discovery of Novel Quinoline-Chalcone Derivatives as Potent Antitumor Agents with Microtubule Polymerization Inhibitory Activity.
AID1597935	Antiproliferative activity against human SGC7901 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	2019	Bioorganic & medicinal chemistry letters, 09-15, Volume: 29, Issue:18	Anti-tumor activity evaluation of novel tubulin and HDAC dual-targeting inhibitors.
AID665824	Inhibition of tubulin polymerization in human A549 cells assessed as disrupted microtubule organization at 2 uM after 48 hrs by immunohistochemistry analysis	2012	Bioorganic & medicinal chemistry, Jun-01, Volume: 20, Issue:11	Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents.
AID1595693	Antiproliferative activity against human H22 cells assessed as reduction in cell viability after 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Jul-01, Volume: 173	Design, synthesis and biological evaluation of pyridine-chalcone derivatives as novel microtubule-destabilizing agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (4.00)	18.2507
2000's	8 (32.00)	29.6817
2010's	14 (56.00)	24.3611
2020's	2 (8.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	25 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
nocodazole [no description available]	2.07	1	aromatic ketone; benzimidazoles; carbamate ester; thiophenes	antimitotic; antineoplastic agent; microtubule-destabilising agent; tubulin modulator
metronidazole Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.. metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.	2.05	1	C-nitro compound; imidazoles; primary alcohol	antiamoebic agent; antibacterial drug; antimicrobial agent; antiparasitic agent; antitrichomonal drug; environmental contaminant; prodrug; radiosensitizing agent; xenobiotic
vorinostat Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.. vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).	2.21	1	dicarboxylic acid diamide; hydroxamic acid	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor
amoxicillin Amoxicillin: A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.. amoxicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group.	2.05	1	penicillin allergen; penicillin	antibacterial drug
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	2.89	3	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
clarithromycin Clarithromycin: A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.. clarithromycin : The 6-O-methyl ether of erythromycin A, clarithromycin is a macrolide antibiotic used in the treatment of respiratory-tract, skin and soft-tissue infections. It is also used to eradicate Helicobacter pylori in the treatment of peptic ulcer disease. It prevents bacteria from growing by interfering with their protein synthesis.	2.05	1	macrolide antibiotic	antibacterial drug; environmental contaminant; protein synthesis inhibitor; xenobiotic
methotrexate [no description available]	2.05	1	dicarboxylic acid; monocarboxylic acid amide; pteridines	abortifacient; antimetabolite; antineoplastic agent; antirheumatic drug; dermatologic drug; DNA synthesis inhibitor; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; immunosuppressive agent
indoximod [no description available]	2.25	1
chalcone trans-chalcone : The trans-isomer of chalcone.	7.97	4	chalcone	EC 3.2.1.1 (alpha-amylase) inhibitor
2'-hydroxychalcone 2'-hydroxychalcone : A member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 2'.	2.05	1	chalcones; phenols	anti-inflammatory agent
isoliquiritigenin [no description available]	2.05	1	chalcones	antineoplastic agent; biological pigment; EC 1.14.18.1 (tyrosinase) inhibitor; GABA modulator; geroprotector; metabolite; NMDA receptor antagonist
4-hydroxycinnamoylmethane 4-hydroxycinnamoylmethane: RN given refers to cpd without isomeric designation. p-hydroxyphenylbut-3-ene-2-one : An enone in which a 4-hydroxyphenyl group is attached to the beta-carbon atom of but-3-en-2-one.	1.99	1
methyl-thiohydantoin-tryptophan methyl-thiohydantoin-tryptophan: structure in first source	2.1	1	organonitrogen compound; organooxygen compound
quercetin 3-o-glucuronide quercetin 3-O-glucuronide: structure in first source. miquelianin : A quercetin O-glycoside that consists of quercetin attached to a beta-D-glucuronopyranosyl moiety at position 3 via a glycosidic linkage. Isolated from Salvia and Phaseolus vulgaris, it exhibits antioxidant and antidepressant activities.	2.05	1	beta-D-glucosiduronic acid; quercetin O-glycoside	antidepressant; antioxidant; metabolite
apigenin Chamomile: Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.	2.05	1	trihydroxyflavone	antineoplastic agent; metabolite
luteolin [no description available]	2.05	1	3'-hydroxyflavonoid; tetrahydroxyflavone	angiogenesis inhibitor; anti-inflammatory agent; antineoplastic agent; apoptosis inducer; c-Jun N-terminal kinase inhibitor; EC 2.3.1.85 (fatty acid synthase) inhibitor; immunomodulator; nephroprotective agent; plant metabolite; radical scavenger; vascular endothelial growth factor receptor antagonist
luteolin-7-glucoside luteolin-7-glucoside: has both antiasthmatic and antineoplastic activities; has 3C protease inhibitory activity; isolated from Ligustrum lucidum. luteolin 7-O-beta-D-glucoside : A glycosyloxyflavone that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.	2.05	1	beta-D-glucoside; glycosyloxyflavone; monosaccharide derivative; trihydroxyflavone	antioxidant; plant metabolite
butein [no description available]	2.46	2	chalcones; polyphenol	antineoplastic agent; antioxidant; EC 1.1.1.21 (aldehyde reductase) inhibitor; geroprotector; hypoglycemic agent; plant metabolite; radiosensitizing agent; tyrosine kinase inhibitor
kaempferol-3-o-galactoside kaempferol-3-O-galactoside: isolated from Ardisia pusilla; RN given refers to (3-(beta-D-galactopyranosyloxy))-isomer. kaempferol 3-O-beta-D-galactoside : A beta-D-galactoside compound with a 4',5,7-trihydroxychromen-3-yl group at the anomeric position.	2.05	1	beta-D-galactoside; glycosyloxyflavone; monosaccharide derivative; trihydroxyflavone	antifungal agent; plant metabolite
4-hydroxychalcone 4-hydroxychalcone: structure in first source. 4-hydroxychalcone : A member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 4.	2.45	2	chalcones; phenols	antihypertensive agent; plant metabolite
fosbretabulin [no description available]	3.82	10	stilbenoid
flavokawain a flavokawain A: from kava extract, induces apoptosis in bladder cancer cells; structure in first source	2.05	1	chalcones
flavokawain b flavokawain B: from Piper methysticum Forst (Kava Kava) roots; structure in first source. flavokawain B : A member of the class of chalcones that consists of trans-chalcone substituted by hydroxy group at positions 2' and methoxy groups at positions 4' and 6'. Isolated from Piper methysticum and Piper rusbyi, it exhibits antileishmanial, anti-inflammatory and antineoplastic activities.	2.05	1	chalcones; dimethoxybenzene; phenols	anti-inflammatory agent; antileishmanial agent; antineoplastic agent; apoptosis inducer; metabolite
4,4'-dichlorochalcone 4,4'-dichlorochalcone: structure in first source	2.05	1
4-chlorochalcone 4-chlorochalcone : A member of the class of chalcones that is trans-chalcone substituted by a chloro group at position 4.	2.05	1	chalcones; monochlorobenzenes
dimethylaminochalcone 4-dimethylaminochalcone: a fluorescent probe; structure in first source	2.05	1
1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene [no description available]	2.02	1
metochalcone metochalcone: structure	2.05	1
phenyl-3-methoxy-4-hydroxystyryl ketone phenyl-3-methoxy-4-hydroxystyryl ketone: structure given in first source	2.05	1
3',4',5',3,4,5-hexamethoxy-chalcone [no description available]	2.74	3
mdl 27048 MDL 27048: structure given in first source; powerful & reversible microtubule inhibitor	2.71	3
combretastatin a-4 disodium phosphate [no description available]	2.5	2
3,4-methylenedioxy-3',4',5'-trimethoxy chalcone [no description available]	2.42	2
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone: an interleukin-1beta converting enzyme (ICE)-like protease inhibitor	2.13	1

Condition	Relationship Strength	Studies
Cell Transformation, Neoplastic Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.	2.05	1
Cancer of Lung [description not available]	2.77	3
Lung Neoplasms Tumors or cancer of the LUNG.	2.77	3
Infections, Helicobacter [description not available]	2.05	1
Gastritis Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders.	2.05	1
Helicobacter Infections Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.	2.05	1
Neuroblastoma A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)	2.06	1
Experimental Neoplasms [description not available]	2.9	3
Cancer of Liver [description not available]	2.21	1
Liver Neoplasms Tumors or cancer of the LIVER.	2.21	1
Benign Neoplasms [description not available]	2.53	2
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.53	2

3-hydroxy-4,3',4',5'-tetramethoxychalcone

Description

Cross-References

Synonyms (20)

Research Excerpts

Bioavailability

Protein Targets (16)

Inhibition Measurements

Biological Processes (51)

Molecular Functions (21)

Ceullar Components (36)

Bioassays (148)

Research

Studies (25)

Market Indicators

Research Demand Index: 12.26

Study Types

3-hydroxy-4,3',4',5'-tetramethoxychalcone

Description

Cross-References

Synonyms (20)

Research Excerpts

Bioavailability

Protein Targets (16)

Inhibition Measurements

Biological Processes (51)

Molecular Functions (21)

Ceullar Components (36)

Bioassays (148)

Research

Studies (25)

Market Indicators

Research Demand Index: 12.26

Study Types

Related Drugs (34)

Related Conditions (12)