metronidazole has been researched along with Fractures, Closed in 1 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Fractures, Closed: Fractures in which the break in bone is not accompanied by an external wound.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tetanus is a severe infectious disease that can lead to death." | 1.46 | An unusual complication of the traditional treatment of a closed fracture - generalized tetanus: a case report. ( Danwang, C; Essomba, A; Guifo, ML; Kalla, GC; Ndame, EK; Tchuenkam, LW, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tchuenkam, LW | 1 |
| Ndame, EK | 1 |
| Guifo, ML | 1 |
| Danwang, C | 1 |
| Kalla, GC | 1 |
| Essomba, A | 1 |
1 other study available for metronidazole and Fractures, Closed
| Article | Year |
|---|---|
An unusual complication of the traditional treatment of a closed fracture - generalized tetanus: a case report.
Topics: Adolescent; Anti-Infective Agents; Fatal Outcome; Fractures, Closed; Humans; Male; Metronidazole; Te | 2017 |