metronidazole has been researched along with Dehiscence, Surgical Wound in 12 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Of 1,184 patients who completed the follow-up protocol, 88 patients (male: female = 31:57) who had received metronidazole could be matched by gender, age, NSAIDs used, number of hemorrhoids resected and operation in the same period with 88 patients (male:female = 31:57) who had not." | 3.74 | Antibiotics and early post operative complications of closed hemorrhoidectomy: a retrospective matched pair study. ( Pattana-arun, J; Wesarachawit, W, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Romero-Pizarro, Y | 1 |
| Muñoz-Algarra, M | 1 |
| Fernández-Mateos, C | 1 |
| Sánchez-Romero, I | 1 |
| Treszezamsky, AD | 1 |
| Feldman, D | 1 |
| Sarabanchong, VO | 1 |
| Wesarachawit, W | 1 |
| Pattana-arun, J | 1 |
| Morris, DL | 1 |
| Hares, MM | 1 |
| Voogt, RJ | 1 |
| Burdon, DW | 1 |
| Keighley, MR | 2 |
| Marti, MC | 1 |
| Auckenthaler, R | 1 |
| Higgins, AF | 1 |
| Lewis, A | 1 |
| Noone, P | 1 |
| Hole, ML | 1 |
| Matheson, DM | 1 |
| Arabi, Y | 1 |
| Baxter-Smith, D | 1 |
| Alexander-Williams, J | 1 |
| Haverich, A | 1 |
| Frimpong-Boateng, K | 1 |
| Wahlers, T | 1 |
| Schäfers, HJ | 1 |
| Juul, P | 1 |
| Klaaborg, KE | 1 |
| Kronborg, O | 1 |
| Entner, M | 1 |
| Heimberger, H | 1 |
| Borden, EB | 1 |
| Sammartano, RJ | 1 |
| Dembe, C | 1 |
| Boley, SJ | 1 |
| Hildebrandt, J | 1 |
| Diettrich, H | 1 |
1 review available for metronidazole and Dehiscence, Surgical Wound
| Article | Year |
|---|---|
[Postoperative recurrence of subdural empyema].
Topics: Aged; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Combined Modality Therap | 2011 |
5 trials available for metronidazole and Dehiscence, Surgical Wound
| Article | Year |
|---|---|
Metronidazole need not be combined with an aminoglycoside when used for prophylaxis in elective colorectal surgery.
Topics: Abscess; Aged; Colon; Drug Therapy, Combination; Female; Gentamicins; Humans; Male; Metronidazole; M | 1983 |
[Antibiotic prophylaxis in colorectal surgery: results of a randomized clinical study].
Topics: Anti-Bacterial Agents; Clindamycin; Clinical Trials as Topic; Colon; Drug Combinations; Gentamicins; | 1982 |
Single and multiple dose cotrimoxazole and metronidazole in colorectal surgery.
Topics: Adult; Aged; Colon; Drug Administration Schedule; Drug Combinations; Female; Humans; Male; Metronida | 1980 |
Randomized multicentre trial of oral bowel preparation and antimicrobials for elective colorectal operations.
Topics: Administration, Oral; Clinical Trials as Topic; Colon; Double-Blind Method; Female; Food, Formulated | 1978 |
Single or multiple doses of metronidazole and ampicillin in elective colorectal surgery. A randomized trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ampicillin; Clinical Trials as Topic; Colon; Drug Therap | 1987 |
6 other studies available for metronidazole and Dehiscence, Surgical Wound
| Article | Year |
|---|---|
Concurrent postpartum uterine and abdominal wall dehiscence and Streptococcus anginosus infection.
Topics: Abdominal Wall; Acute Disease; Adolescent; Anti-Bacterial Agents; Ascitic Fluid; Cefazolin; Cesarean | 2011 |
Antibiotics and early post operative complications of closed hemorrhoidectomy: a retrospective matched pair study.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotic Prophylaxis | 2007 |
Pericardial flap-plasty for protection of the tracheal anastomosis in heart-lung transplantation.
Topics: Adult; Anastomosis, Surgical; Child, Preschool; Female; Fibrin Tissue Adhesive; Heart-Lung Transplan | 1989 |
One row anastomosis in colonic operations with antibiotic prophylaxis.
Topics: Adolescent; Adult; Aged; Colon; Colonic Neoplasms; Diverticulitis, Colonic; Humans; Metronidazole; M | 1985 |
The effect of metronidazole on wound healing in rats.
Topics: Animals; Fascia; Metronidazole; Rats; Rats, Inbred Strains; Skin; Surgical Wound Dehiscence; Tensile | 1985 |
[Modern mechanical antibiotic preparation in colorectal operations. Results of a prospective study].
Topics: Anti-Bacterial Agents; Chloramphenicol; Colonic Neoplasms; Drug Administration Schedule; Drug Therap | 1985 |