metronidazole has been researched along with Dental Caries in 13 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Dental Caries: Localized destruction of the tooth surface initiated by decalcification of the enamel followed by enzymatic lysis of organic structures and leading to cavity formation. If left unchecked, the cavity may penetrate the enamel and dentin and reach the pulp.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Molars with carious lesions on the inner half of dentin without clinical or radiographic pulp damage were selected." | 2.78 | Use of glass ionomer cement containing antibiotics to seal off infected dentin: a randomized clinical trial. ( Ferreira, JM; Menezes, VA; Pinheiro, SL; Sampaio, FC, 2013) |
| "Placebo experiments in which carious dentin was covered by TCP cement without MN showed that TCP itself was not bactericidal." | 2.66 | Bactericidal efficacy of metronidazole against bacteria of human carious dentin in vivo. ( Ando, N; Hoshino, E; Iwaku, M; Kota, K; Sato, M, 1989) |
| "We report a patient with multiple brain abscesses due to infection with A." | 2.47 | Brain abscess associated with Aggregatibacter actinomycetemcomitans: case report and review of literature. ( Engström, LJ; Manson, WL; Mooi-Kokenberg, EA; Rahamat-Langendoen, JC; van Vonderen, MG; van Winkelhoff, AJ, 2011) |
| "Caries/pulpitis was the most common diagnosis (n = 222; 31% of cases), of which 48 (21%) were prescribed antibiotics." | 1.42 | Diagnosis and prescribing pattern of antibiotics and painkillers among dentists. ( Lundborg, CS; Marrone, G; Tanwir, F; Tariq, A, 2015) |
| "Cerebral actinomycosis is rare and difficult to diagnose." | 1.37 | [Cerebral actinomycosis pseudotumor: a case report]. ( Battikh, R; Ben Abdelhafidh, N; Bougrine, F; Bouziani, A; M'Sadek, F; Madhi, W; Othmani, S; Yedeas, M, 2011) |
| "Presence of dental caries may inhibit drug diffusion through dentine into the pulp." | 1.32 | Facilitation of iontophoretic drug delivery through intact and caries-affected dentine. ( Ikeda, H; Puapichartdumrong, P; Suda, H, 2003) |
| "No bacteria were recovered from carious lesions in vitro (six samples) or in vivo (four samples) after the lesions were covered by the antibacterial temporary cement." | 1.30 | Bactericidal eradication from carious lesions of prepared abutments by an antibacterial temporary cement. ( Hori, R; Hoshino, E; Kohno, S, 1997) |
| "Samples taken from carious dentin (17 cases) and infected pulpal tissues (14 cases) were cultured on control plates and plates containing the mixed drugs." | 1.29 | In vitro antimicrobial susceptibility to combinations of drugs on bacteria from carious and endodontic lesions of human deciduous teeth. ( Hoshino, E; Noda, T; Sato, T; Uematsu, H, 1993) |
| "Bacteria taken from carious dentine (25 cases) and infected pulps (12 cases) were also sensitive to the drug combination." | 1.29 | In-vitro antibacterial susceptibility of bacteria taken from infected root dentine to a mixture of ciprofloxacin, metronidazole and minocycline. ( Hoshino, E; Iwaku, M; Kota, K; Kurihara-Ando, N; Sato, I; Sato, M; Uematsu, H, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (15.38) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ferreira, JM | 1 |
| Pinheiro, SL | 2 |
| Sampaio, FC | 1 |
| Menezes, VA | 1 |
| Tanwir, F | 1 |
| Marrone, G | 1 |
| Tariq, A | 1 |
| Lundborg, CS | 1 |
| Battikh, R | 1 |
| M'Sadek, F | 1 |
| Bougrine, F | 1 |
| Madhi, W | 1 |
| Ben Abdelhafidh, N | 1 |
| Bouziani, A | 1 |
| Yedeas, M | 1 |
| Othmani, S | 1 |
| Rahamat-Langendoen, JC | 1 |
| van Vonderen, MG | 1 |
| Engström, LJ | 1 |
| Manson, WL | 1 |
| van Winkelhoff, AJ | 1 |
| Mooi-Kokenberg, EA | 1 |
| Trairatvorakul, C | 1 |
| Detsomboonrat, P | 1 |
| Puapichartdumrong, P | 1 |
| Ikeda, H | 1 |
| Suda, H | 1 |
| Rumiantsev, VA | 1 |
| Iusufov, MV | 1 |
| Khiutti, NV | 1 |
| Moskaleva, IV | 1 |
| Slobodina, EV | 1 |
| Simionato, MR | 1 |
| Imparato, JC | 1 |
| Oda, M | 1 |
| Sato, T | 1 |
| Hoshino, E | 5 |
| Uematsu, H | 2 |
| Noda, T | 1 |
| Hori, R | 1 |
| Kohno, S | 1 |
| Kurihara-Ando, N | 1 |
| Sato, I | 1 |
| Sato, M | 3 |
| Kota, K | 3 |
| Iwaku, M | 3 |
| Ando, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 1 Study of Clinical and Radiographic Success of Antibacterial Cement in Infected Dentin of Deciduous Teeth[NCT01449136] | 45 participants (Actual) | Interventional | 2008-01-31 | Completed | |||
| A Randomized Controlled Trial Comparing the Clinical and Radiographic Success of 3Mixtatin Versus Modified 3Mix in Lesion Sterilization and Tissue Repair (LSTR) for The Treatment of Necrotic Primary Molars[NCT05677945] | 24 participants (Anticipated) | Interventional | 2023-03-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metronidazole and Dental Caries
| Article | Year |
|---|---|
Brain abscess associated with Aggregatibacter actinomycetemcomitans: case report and review of literature.
Topics: Actinobacillus Infections; Adult; Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Anti | 2011 |
3 trials available for metronidazole and Dental Caries
| Article | Year |
|---|---|
Use of glass ionomer cement containing antibiotics to seal off infected dentin: a randomized clinical trial.
Topics: Anti-Bacterial Agents; Cariostatic Agents; Cefaclor; Chi-Square Distribution; Child; Child, Preschoo | 2013 |
Antibacterial activity of glass-ionomer cement containing antibiotics on caries lesion microorganisms.
Topics: Anti-Bacterial Agents; Bacteria; Cefaclor; Child; Child, Preschool; Ciprofloxacin; Colony Count, Mic | 2005 |
Bactericidal efficacy of metronidazole against bacteria of human carious dentin in vivo.
Topics: Adolescent; Bacteria; Calcium Phosphates; Child; Dental Caries; Dental Cavity Lining; Dental Cavity | 1989 |
9 other studies available for metronidazole and Dental Caries
| Article | Year |
|---|---|
Diagnosis and prescribing pattern of antibiotics and painkillers among dentists.
Topics: Adolescent; Adult; Amoxicillin; Analgesics; Anti-Bacterial Agents; Child; Child, Preschool; Cross-Se | 2015 |
[Cerebral actinomycosis pseudotumor: a case report].
Topics: Actinomycosis; Adrenal Cortex Hormones; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacteria | 2011 |
Success rates of a mixture of ciprofloxacin, metronidazole, and minocycline antibiotics used in the non-instrumentation endodontic treatment of mandibular primary molars with carious pulpal involvement.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bisphenol A-Glycidyl Methacrylate; Child; Child, Presc | 2012 |
Facilitation of iontophoretic drug delivery through intact and caries-affected dentine.
Topics: Adult; Analysis of Variance; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Dental | 2003 |
[Comparative study by pH-tests of the efficacy of antimicrobial agents in oral cavity].
Topics: Adult; Anti-Infective Agents, Local; Bacteria; Chlorhexidine; Dental Caries; Female; Humans; Hydroge | 2005 |
In vitro antimicrobial susceptibility to combinations of drugs on bacteria from carious and endodontic lesions of human deciduous teeth.
Topics: Amoxicillin; Bacteria, Anaerobic; Cefaclor; Child; Child, Preschool; Ciprofloxacin; Dental Caries; D | 1993 |
Bactericidal eradication from carious lesions of prepared abutments by an antibacterial temporary cement.
Topics: Adult; Anti-Bacterial Agents; Bacteria; Cefaclor; Cephalosporins; Ciprofloxacin; Colony Count, Micro | 1997 |
In-vitro antibacterial susceptibility of bacteria taken from infected root dentine to a mixture of ciprofloxacin, metronidazole and minocycline.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Bacteria, Anaerobic; Cip | 1996 |
Bactericidal efficacy of metronidazole against bacteria of human carious dentin in vitro.
Topics: Bacteria; Bacteriological Techniques; Calcium Phosphates; Dental Caries; Dental Cements; Dentin; Hum | 1988 |