metronidazole has been researched along with Atypical Mycobacterial Infection, Disseminated in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "2h) and low absolute bioavailability (1." | 1.42 | Novel, potent, orally bioavailable and selective mycobacterial ATP synthase inhibitors that demonstrated activity against both replicating and non-replicating M. tuberculosis. ( Chaturvedi, V; Dasgupta, A; Gupta, AD; Jaiswal, S; Kashyap, VK; Khan, SR; Krishnan, MY; Lal, J; Roy, KK; Saxena, AK; Sharma, A; Sharma, SK; Singh, S; Sinha, S; Srivastava, R, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Singh, S | 1 |
| Roy, KK | 1 |
| Khan, SR | 1 |
| Kashyap, VK | 1 |
| Sharma, A | 1 |
| Jaiswal, S | 1 |
| Sharma, SK | 1 |
| Krishnan, MY | 1 |
| Chaturvedi, V | 1 |
| Lal, J | 1 |
| Sinha, S | 1 |
| Dasgupta, A | 1 |
| Gupta, AD | 1 |
| Srivastava, R | 1 |
| Saxena, AK | 1 |
| Simo, R | 1 |
| Hartley, C | 1 |
| Rapado, F | 1 |
| Zarod, AP | 1 |
| Sanyal, D | 1 |
| Rothera, MP | 1 |
| Semret, M | 1 |
| Koromihis, G | 1 |
| MacLean, JD | 1 |
| Libman, M | 1 |
| Ward, BJ | 1 |
3 other studies available for metronidazole and Atypical Mycobacterial Infection, Disseminated
| Article | Year |
|---|---|
Novel, potent, orally bioavailable and selective mycobacterial ATP synthase inhibitors that demonstrated activity against both replicating and non-replicating M. tuberculosis.
Topics: Adenosine Triphosphate; Animals; Antitubercular Agents; Male; Mice; Mice, Inbred BALB C; Molecular D | 2015 |
Microbiology and antibiotic treatment of head and neck abscesses in children.
Topics: Abscess; Adolescent; Anti-Bacterial Agents; Bacteria, Anaerobic; Child; Child, Preschool; Drainage; | 1998 |
Mycobacterium ulcerans infection (Buruli ulcer): first reported case in a traveler.
Topics: Adult; Africa; Anti-Bacterial Agents; Antibiotics, Antitubercular; Antitubercular Agents; Ciprofloxa | 1999 |