metronidazole has been researched along with Hypopharyngeal Neoplasms in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Hypopharyngeal Neoplasms: Tumors or cancer of the HYPOPHARYNX.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schreiber, A | 1 |
| Krause, M | 1 |
| Zips, D | 1 |
| Dörfler, A | 1 |
| Richter, K | 1 |
| Vettermann, S | 1 |
| Petersen, C | 1 |
| Beuthien-Baumann, B | 1 |
| Thümmler, D | 1 |
| Baumann, M | 1 |
| Brusis, T | 1 |
| Luckhaupt, H | 1 |
2 other studies available for metronidazole and Hypopharyngeal Neoplasms
| Article | Year |
|---|---|
Effect of the hypoxic cell sensitizer isometronidazole on local control of two human squamous cell carcinomas after fractionated irradiation.
Topics: Animals; Carcinoma, Squamous Cell; Dose Fractionation, Radiation; Female; Humans; Hypopharyngeal Neo | 2004 |
[Anaerobic infections in ulcerating tumors of the head and neck. A contribution to the problem of odors].
Topics: Bacteria, Anaerobic; Bacterial Infections; Bacteroides Infections; Clindamycin; Head and Neck Neopla | 1986 |