Lemierre Disease

A superinfection of the damaged oropharyngeal mucosa by FUSOBACTERIUM NECROPHORUM leading to the secondary septic THROMBOPHLEBITIS of the internal jugular vein.

Synonym
Postanginal Sepsis
Lemierre Syndrome
Lemierre Disease
Lemierre's Disease
Lemierre's Syndrome

Excerpt	Reference
"Lemierre's syndrome is a classical presentation of human necrobacillosis."	( Allaouchiche, B; Faure, F; Floccard, B; Hautin, E; Valleix, B, 2011)
"Lemierre's syndrome is a disseminated infection which is usually caused by Fusobacterium necrophorum."	( Reinholdt Jensen, J; Weinreich, UM, 2012)
"Lemierre's syndrome is a rare condition involving septic thrombophlebitis of the internal jugular vein secondary to an acute oropharyngeal infection."	( Phan, T; So, TY, 2012)
"Lemierre syndrome is an uncommon disease which commonly arise from acute bacterial oropharyngeal infection."	( Lim, AL; Pua, KC, 2012)
"Lemierre's syndrome is a rare yet potentially fatal cause of sore throat."	( Dholakia, S; Hashimi, Y, 2013)
"Lemierre's syndrome is an often un-diagnosed disease seen in previously healthy young subjects, presenting with symptoms of pharyngitis, fever and elevated markers of inflammation."	( Bødtger, U; Heltberg, O; Johannesen, K, 2014)
"Lemierre syndrome is a rare but serious illness that associates throat infection and thrombosis of the internal jugular vein (IJV) or one of its tributaries with subsequent distant septic emboli."	( Atallah, I; Karkas, A; N'Gouan, JM; Reyt, E; Righini, CA; Schmerber, S; Tourniaire, R, 2014)
"Lemierre's syndrome is a condition characterized by thrombophlebitis of the internal jugular vein and bacteremia caused by primarily anaerobic organisms, following a recent oropharyngeal infection."	( Aslanidis, T; Giannakou-Peftoulidou, M; Myrou, A, 2014)
"Lemierre syndrome is a clinical syndrome that presents with internal jugular thrombophlebitis, septicemia and systemic abscess formations."	( Ito, S; Nakashima, K; Tagashira, S; Takahashi, S; Watanabe, Y; Yasui, K, 2015)
"Lemierre's syndrome is an oropharyngeal bacterial infection characterized by rapidly progressive septic thrombophlebitis of the internal jugular vein."	( Asayama, S; Fujinami, J; Hama, Y; Koga, M; Toyoda, K, 2016)
"Lemierre's syndrome is a condition characterised by suppurative thrombophlebitis of the internal jugular (IJ) vein following a recent oropharyngeal infection, with resulting septicaemia and metastatic lesions."	( Fattah, Z; Vijay, V, 2018)
"Lemierre's syndrome is often misdiagnosed as a common cold or viral infection."	( Alaev, O; Bryan, A; Gelfman, A; Gennaro, D; Le, C; Marshall, D; Wang, Z, 2019)
"Typical Lemierre's syndrome is usually secondary to an oropharyngeal infection."	( Aoki, K; Aritomo, H; Ikeuchi, H; Iwasaka, M; Katsura, M; Mishima, K; Mizuki, S; Oryoji, K; Shirai, Y; Tatsutani, T, 2023)
"Lemierre syndrome is typically associated with ear, nose, and throat (ENT) infections caused by Fusobacterium necrophorum."	( Benaboud, S; Collignon, C; de Marcellus, C; El Hajj, R; Kossorotoff, M; Moulin, F; Oualha, M; Remangeon, F; Roux, CJ; Stanzelova, A; Toubiana, J; Touzé, R, 2023)

Excerpt	Reference
"Lemierre syndrome has been reported to be serious and potentially fatal in the preantibiotic era."	( Lim, AL; Pua, KC, 2012)

Excerpt	Reference
"The diagnosis of Lemierre's syndrome was confirmed, and he was effectively treated with appropriate antibiotics and anti-coagulation."	( Price, K; Tsegaye, M; Wilson, L, 2012)
"In individual cases of Lemierre syndrome with brain abscess caused by ESBL-producing Enterobacteriaceae, fosfomycin combination therapy may be the alternative choice."	( Lee, WS; Ou, TY; Shieh, YH; Teng, SO; Wang, FD, 2012)
"It is suggested to screen patients with Lemierre's syndrome for a hypercoagulable state to consider anticoagulant therapy."	( Behpour-Oskooee, M; Karimi, A; Sayyahfar, S, 2014)
"This was a case of Lemierre syndrome with a rare combination of clivus osteomyelitis and a steroid-responsive tumour in the cavernous sinus-suprasellar region that was successfully treated."	( Ito, S; Nakashima, K; Tagashira, S; Takahashi, S; Watanabe, Y; Yasui, K, 2015)
"Two cases of Lemierre's syndrome were treated successfully with only 2-4 weeks of metronidazole therapy."	( Alaev, O; Bryan, A; Gelfman, A; Gennaro, D; Le, C; Marshall, D; Wang, Z, 2019)
"He was diagnosed with Lemierre's syndrome (LS) and treated with a prolonged course of antibiotics and anticoagulation."	( Alanazi, S; Alfattoh, N; Bawazeer, M; Hameed, T, 2020)
"We describe an atypical Lemierre's syndrome in a 72-year-old woman with rheumatoid arthritis, which occurred during the treatment of Streptococcus anginosus bacteremia acquired from a sacral ulcer infection related to rheumatoid vasculitis."	( Aoki, K; Aritomo, H; Ikeuchi, H; Iwasaka, M; Katsura, M; Mishima, K; Mizuki, S; Oryoji, K; Shirai, Y; Tatsutani, T, 2023)
"Clinicians should consider Lemierre's syndrome as the differential diagnosis of internal jugular vein thrombosis occurring during sepsis, even though an antibiotic is administered or a primary infection site is anything besides the oropharynx."	( Aoki, K; Aritomo, H; Ikeuchi, H; Iwasaka, M; Katsura, M; Mishima, K; Mizuki, S; Oryoji, K; Shirai, Y; Tatsutani, T, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	53 (85.48)	28.8240
2020's	9 (14.52)	9.53

Drug	Relationship Strength	Studies	Trials
dalteparin	low	4	0
aspirin	low	1	0
hydroxychloroquine	low	1	0
ibuprofen	low	2	0
iohexol	low	1	0
metronidazole	low	16	0
ofloxacin	low	1	0
prednisolone	low	1	0
penicillin g	low	2	0
methicillin	low	4	0
cloxacillin	low	1	0
colchicine	low	1	0
ampicillin	low	4	0
methylprednisolone	low	1	0
penicillanic acid	low	2	0
thiazoles	low	1	0
methamphetamine	low	1	0
vancomycin	low	1	0
trolamine salicylate	low	1	0
cefazolin	low	1	0
amoxicillin	low	3	0
propiconazole	low	2	0
piperacillin	low	2	0
doripenem	low	1	0
oxazolidin-2-one	low	1	0
imipenem, anhydrous	low	1	0
sulbactam	low	3	0
carbapenems	low	1	0
beta-lactams	low	2	0
ertapenem	low	1	0
meropenem	low	5	0
linezolid	low	1	0
sultamicillin	low	3	0
mycophenolic acid	low	1	0
clindamycin	low	10	0
fosfomycin	low	1	0
zithromax	low	2	0
l 743,872	low	1	0
vitamin k semiquinone radical	medium	1	1
heroin	low	1	0
amoxicillin-potassium clavulanate combination	low	5	0
rivaroxaban	low	1	0
edoxaban	low	1	0
ent-dextilidine	low	1	0
ro13-9904	low	11	0
piperacillin, tazobactam drug combination	low	3	0
warfarin	low	4	0
acyclovir	low	1	0
rifampin	low	1	0
eye	low	2	0

Protein Targets (549)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Chain A, Ferritin light chain	5	0	0	5
Thymidine kinase	0	1	0	1
thioredoxin reductase	6	0	0	6
phosphopantetheinyl transferase	3	0	0	3
GLS protein	5	0	0	5
TDP1 protein	10	0	0	10
Smad3	3	0	0	3
thyroid stimulating hormone receptor	6	0	0	6
EWS/FLI fusion protein	7	0	0	7
arylsulfatase A	4	0	0	4
euchromatic histone-lysine N-methyltransferase 2	11	0	0	11
activating transcription factor 6	4	0	0	4
Histone H2A.x	4	0	0	4
Bloom syndrome protein isoform 1	2	0	0	2
hemoglobin subunit beta	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
lamin isoform A-delta10	9	0	0	9
Solute carrier family 22 member 1	0	1	0	2
ATP-binding cassette sub-family C member 3	0	16	0	16
Multidrug resistance-associated protein 4	0	16	0	17
Solute carrier family 22 member 6	0	4	0	5
Bile salt export pump	0	6	0	6
Bile salt export pump	0	23	0	23
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2C9	0	7	0	8
Cytochrome P450 2J2	0	4	0	4
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	2	0	3
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	3	0	4
Canalicular multispecific organic anion transporter 1	0	16	0	16
Thymidine kinase	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
Chain A, Beta-lactamase	6	0	0	6
Chain A, 2-oxoglutarate Oxygenase	6	0	0	6
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	4
Beta-lactamase	0	0	0	5
Beta-lactamase	0	1	0	5
AR protein	10	0	0	10
apical membrane antigen 1, AMA1	3	0	0	3
estrogen nuclear receptor alpha	15	0	0	15
Beta-lactamase	0	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	6	0	0	6
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
DNA polymerase kappa isoform 1	4	0	0	4
Beta-lactamase SHV-1	0	0	0	3
Beta-lactamase SHV-1	0	1	0	7
Beta-lactamase	0	1	0	7
Kappa-type opioid receptor	0	0	0	4
Solute carrier family 15 member 1	0	7	0	7
Solute carrier family 15 member 1	0	2	0	2
B2 metallo-beta-lactamase	0	0	0	4
Solute carrier family 15 member 2	0	4	0	4
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
Solute carrier family 15 member 2	0	4	0	4
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	4
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, Cruzipain	2	0	0	2
Beta-lactamase	0	2	0	4
acid sphingomyelinase	1	0	0	1
GLI family zinc finger 3	8	0	0	8
retinoic acid nuclear receptor alpha variant 1	7	0	0	7
farnesoid X nuclear receptor	5	0	0	5
Beta-lactamase	0	0	0	4
Beta-lactamase	0	0	0	5
Metallo-beta-lactamase type 2	0	0	1	6
Metallo-beta-lactamase VIM-11	0	0	0	4
Metallo-beta-lactamase VIM-2	0	0	0	4
Beta-lactamase	0	1	0	7
Metallo-beta-lactamase	0	0	0	4
Beta-lactamase	0	0	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
chromobox protein homolog 1	6	0	0	6
thyroid hormone receptor beta isoform 2	8	0	0	8
DNA polymerase beta	1	0	0	1
geminin	10	0	0	10
Carbonic anhydrase 1	0	3	0	3
Carbonic anhydrase 2	0	3	0	3
60 kDa heat shock protein, mitochondrial	0	3	0	3
Beta-lactamase OXA-7	0	0	0	3
Spike glycoprotein	2	0	1	3
10 kDa heat shock protein, mitochondrial	0	3	0	3
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	1	0	3
Beta-lactamase	0	1	0	3
Beta-lactamase	0	1	0	3
Thiosulfate sulfurtransferase	0	3	0	3
Metallo-beta-lactamase VIM-13	0	0	0	5
Efflux transporter	0	1	0	3
Beta-lactamase	0	0	0	4
Beta-lactamase Toho-1	0	0	0	2
Beta-lactamase	0	1	0	3
Class D beta-lactamase	0	1	0	4
60 kDa chaperonin	0	3	0	3
Metallo-beta-lactamase	0	0	0	3
Beta-lactamase	0	1	0	5
Beta-lactamase	0	0	1	5
10 kDa chaperonin	0	3	0	3
Metallo-b-lactamase	0	0	0	8
Carbapenem-hydrolyzing beta-lactamase KPC	0	1	0	7
Histamine H3 receptor	0	0	0	4
Beta-lactamase class B VIM-2	0	0	1	10
Beta-lactamase VIM-1	0	0	0	5
ATP-dependent phosphofructokinase	3	0	0	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	4	0	0	4
aldehyde dehydrogenase 1 family, member A1	6	0	0	6
hypothetical protein, conserved	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	5	0	0	5
glucocorticoid receptor [Homo sapiens]	10	0	0	10
estrogen-related nuclear receptor alpha	10	0	0	10
cytochrome P450 2D6	2	0	0	2
glucocerebrosidase	2	0	0	2
peroxisome proliferator-activated receptor delta	8	0	0	8
Rac1 protein	0	0	1	1
IDH1	5	0	0	5
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
muscarinic acetylcholine receptor M1	2	0	0	2
lethal factor (plasmid)	4	0	0	4
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Epidermal growth factor receptor	0	2	0	2
Fatty acid-binding protein, liver	0	3	0	3
Integrin beta-3	0	1	0	1
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	0	1	0	1
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	4	0	4
Adenosine receptor A1	0	2	0	2
Adenosine receptor A2a	0	2	0	2
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	4	0	4
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Nuclear receptor ROR-gamma	3	0	0	3
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	3	2	0	5
Prostaglandin G/H synthase 2	0	3	0	3
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	1	3
Sigma non-opioid intracellular receptor 1	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Luciferase	3	0	0	3
RAR-related orphan receptor gamma	7	0	0	7
vitamin D3 receptor isoform VDRA	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 1	9	0	0	9
Solute carrier family 22 member 11	0	1	0	1
Solute carrier family 22 member 8	0	2	0	3
Protein-arginine deiminase type-4	0	2	0	2
Beta-lactamase	0	2	0	4
Solute carrier family 22 member 8	0	3	0	4
Beta-lactamase TEM	0	4	0	8
endonuclease IV	1	0	0	1
PAX8	0	0	0	1
pregnane X receptor	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
ATAD5 protein, partial	2	0	0	2
Fumarate hydratase	1	0	0	1
USP1 protein, partial	4	0	0	4
PPM1D protein	4	0	0	4
Thrombopoietin	1	0	0	1
estrogen receptor 2 (ER beta)	4	0	0	4
nuclear receptor subfamily 1, group I, member 3	5	0	0	5
retinoid X nuclear receptor alpha	10	0	0	10
pregnane X nuclear receptor	8	0	0	8
polyprotein	1	0	0	1
67.9K protein	3	0	0	3
peroxisome proliferator activated receptor gamma	7	0	0	7
vitamin D (1,25- dihydroxyvitamin D3) receptor	6	0	0	6
aryl hydrocarbon receptor	6	0	0	6
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	3	0	0	3
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
cytochrome P450 2D6 isoform 1	1	0	0	1
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
cytochrome P450 2C19 precursor	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
thyroid hormone receptor beta isoform a	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
flap endonuclease 1	2	0	0	2
ras-related protein Rab-9A	1	0	0	1
steroidogenic factor 1	0	1	0	1
peripheral myelin protein 22	3	0	0	3
cytochrome P450 3A4 isoform 1	3	0	0	3
muscleblind-like protein 1 isoform 1	4	0	0	4
caspase-1 isoform alpha precursor	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	3	1	0	4
Solute carrier family 22 member 3	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	4	0	0	4
Interferon beta	8	0	0	8
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	1
Tubulin beta-4A chain	0	2	2	5
Cellular tumor antigen p53	9	0	0	9
ATP-dependent translocase ABCB1	0	1	0	1
Tubulin beta chain	0	2	2	5
ATP-dependent translocase ABCB1	0	1	0	2
Cytochrome P450 3A4	0	4	0	5
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	3	1	0	4
Gamma-aminobutyric acid receptor subunit delta	3	1	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	3	1	0	4
Glutamate receptor 2	4	1	0	5
Gamma-aminobutyric acid receptor subunit alpha-5	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	3	1	0	4
ATP-dependent translocase ABCB1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-4	3	1	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-6	3	1	0	4
Histamine H2 receptor	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-3	3	1	0	4
Gamma-aminobutyric acid receptor subunit beta-2	3	1	0	4
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
GABA theta subunit	3	1	0	4
CREB-binding protein	1	0	0	1
ATPase family AAA domain-containing protein 5	5	0	0	5
Ataxin-2	5	0	0	5
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Gamma-aminobutyric acid receptor subunit epsilon	3	1	0	4
Tubulin beta-1 chain	0	2	2	5
acetylcholinesterase	3	0	0	3
G	4	0	0	4
HLA class I histocompatibility antigen, B alpha chain	4	0	0	4
Beta-lactamase	0	1	0	5
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Sodium channel protein type 5 subunit alpha	0	1	0	1
Beta-lactamase	0	0	0	4
Beta-lactamase	0	0	0	4
Beta-lactamase IMP-1	0	0	0	4
Inositol hexakisphosphate kinase 1	4	0	0	4
Beta-lactamase	0	0	0	4
Beta-lactamase	0	0	0	4
cytochrome P450 2C9, partial	4	0	0	4
Coagulation factor X	0	4	0	4
Metallo-beta-lactamase VIM-19	0	0	0	5
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0	1	0	1
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0	1	0	1
Liver carboxylesterase 1	0	0	0	1
Genome polyprotein	0	1	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Procathepsin L	0	0	1	1
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Alpha-2A adrenergic receptor	0	2	0	2
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	2	1	3
Muscarinic acetylcholine receptor M1	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
NFKB1 protein, partial	1	0	0	1
nonstructural protein 1	3	0	0	3
transcriptional regulator ERG isoform 3	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Albumin	0	1	5	6
Albumin	0	1	0	1
Albumin	0	0	2	2
Cholinesterase	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
UDP-glucuronosyltransferase 2B7	0	0	0	1
Acetylcholinesterase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Caspase-1	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Caspase-3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	2	0	2
Caspase-4	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
TAR DNA-binding protein 43	5	0	0	5
Prostaglandin G/H synthase 1	0	1	0	2
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Beta-lactamase	0	2	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	4
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
BlaVIM-1	0	0	0	4
streptokinase A precursor	0	0	5	5
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
30S ribosomal protein S6	0	2	0	2
30S ribosomal protein S7	0	2	0	2
50S ribosomal protein L15	0	2	0	2
Cytochrome P450 1A2	0	1	0	2
Estrogen receptor	0	0	1	1
50S ribosomal protein L10	0	2	0	2
50S ribosomal protein L11	0	2	0	2
50S ribosomal protein L7/L12	0	2	0	2
50S ribosomal protein L19	0	2	0	2
50S ribosomal protein L1	0	2	0	2
50S ribosomal protein L20	0	2	0	2
50S ribosomal protein L27	0	2	0	2
50S ribosomal protein L28	0	2	0	2
50S ribosomal protein L29	0	2	0	2
50S ribosomal protein L31	0	2	0	2
50S ribosomal protein L31 type B	0	2	0	2
50S ribosomal protein L32	0	2	0	2
50S ribosomal protein L33	0	2	0	2
50S ribosomal protein L34	0	2	0	2
50S ribosomal protein L35	0	2	0	2
50S ribosomal protein L36	0	2	0	2
30S ribosomal protein S10	0	2	0	2
30S ribosomal protein S11	0	2	0	2
30S ribosomal protein S12	0	2	0	2
30S ribosomal protein S13	0	2	0	2
30S ribosomal protein S16	0	2	0	2
30S ribosomal protein S18	0	2	0	2
30S ribosomal protein S19	0	2	0	2
30S ribosomal protein S20	0	2	0	2
30S ribosomal protein S2	0	2	0	2
30S ribosomal protein S3	0	2	0	2
30S ribosomal protein S4	0	2	0	2
30S ribosomal protein S5	0	2	0	2
30S ribosomal protein S8	0	2	0	2
30S ribosomal protein S9	0	2	0	2
50S ribosomal protein L13	0	2	0	2
50S ribosomal protein L14	0	2	0	2
50S ribosomal protein L16	0	2	0	2
50S ribosomal protein L23	0	2	0	2
30S ribosomal protein S15	0	2	0	2
DNA gyrase subunit A	0	2	0	3
DNA gyrase subunit B	0	2	0	3
50S ribosomal protein L17	0	2	0	2
50S ribosomal protein L21	0	2	0	2
50S ribosomal protein L30	0	2	0	2
50S ribosomal protein L6	0	2	0	2
30S ribosomal protein S14	0	2	0	2
30S ribosomal protein S17	0	2	0	2
30S ribosomal protein S1	0	2	0	2
50S ribosomal protein L18	0	2	0	2
Cytochrome P450 2D6	0	1	0	2
Amine oxidase [flavin-containing] B	0	2	0	2
Amine oxidase [flavin-containing] A	0	2	0	2
Amine oxidase [flavin-containing] B	0	1	0	1
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	0	1	0	1
Cytochrome P450 2C19	0	1	0	2
50S ribosomal protein L2	0	2	0	2
50S ribosomal protein L3	0	2	0	2
50S ribosomal protein L24	0	2	0	2
50S ribosomal protein L4	0	2	0	2
50S ribosomal protein L22	0	2	0	2
50S ribosomal protein L5	0	2	0	2
30S ribosomal protein S21	0	2	0	2
50S ribosomal protein L25	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
50S ribosomal protein L36 2	0	2	0	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
Estrogen receptor beta	0	0	1	1
Renin	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Sodium-dependent noradrenaline transporter	0	0	1	1
Sodium-dependent serotonin transporter	0	0	1	1
Amine oxidase [flavin-containing] B	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
progesterone receptor	6	0	0	6
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Glucocorticoid receptor	0	4	1	10
Glycine receptor subunit alpha-1	0	4	0	4
Androgen receptor	0	3	0	3
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Thioredoxin reductase	0	1	0	1
mitogen-activated protein kinase 1	1	0	0	1
Flavodoxin	0	0	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
glp-1 receptor, partial	3	0	0	3
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
survival motor neuron protein isoform d	1	0	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	2	0	2
Glutamate receptor 1	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor 4	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	0	0	1
Sodium-dependent serotonin transporter	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Alpha-synuclein	1	1	0	2
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
STE24	0	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
CAAX prenyl protease	0	0	0	1
histone acetyltransferase KAT2A isoform 1	2	0	0	2
Trypsin	0	0	0	1
DNA gyrase subunit B	0	2	0	3
DNA gyrase subunit A	0	2	0	3
Vpr	1	0	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	3
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	2
Beta-lactamase 1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	3
Beta-lactamase	0	1	0	3
Beta-lactamase	0	0	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
nuclear receptor ROR-gamma isoform 1	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
heat shock protein 90, putative	0	0	0	1
15-lipoxygenase, partial	1	0	0	1
Microtubule-associated protein tau	1	0	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Cytochrome P450 2B6	0	0	1	1
Arylacetamide deacetylase	0	1	0	2
Solute carrier organic anion transporter family member 1A2	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	2	0	3
Chain A, Activated Factor Xa Heavy Chain	0	1	0	1
Prothrombin	0	1	0	1
Coagulation factor XII	0	1	0	1
Suppressor of tumorigenicity 14 protein	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase OXA-1	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Metallo-beta-lactamase type 2	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Transporter	0	1	0	1
thioredoxin glutathione reductase	1	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
thyroid stimulating hormone receptor	1	0	0	1
twin arginine protein translocation system - TatA protein	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(5)

Research Excerpts

Overview

Context

Treatment

Research

Studies (62)

Protein Targets (549)

Lemierre Disease

Synonyms(5)

Research Excerpts

Overview

Context

Treatment

Research

Studies (62)

Drugs Studied (54)

Protein Targets (549)