metronidazole has been researched along with Pharyngeal Neoplasms in 5 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Pharyngeal Neoplasms: Tumors or cancer of the PHARYNX.
| Excerpt | Relevance | Reference |
|---|---|---|
| " On the basis of pharmacokinetic investigations, administration of the antibiotic 30 min preoperatively fulfills this requirement." | 2.66 | [Bacteriological, clinical, and pharmacokinetic studies of perioperative antibiotic prophylaxis in head and neck surgery]. ( Anagnostou, M; Bleier, R; Borneff, M; Geyer, G; Hartmetz, G; Roser, F, 1987) |
| "Schwannoma, or neurilemmoma, is included in the differential diagnosis of masses in the parapharyngeal space." | 1.28 | Rare presentation of a parapharyngeal schwannoma. ( Dilkes, MG; Morrison, GA; Orr, WP, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tsyb, AF | 1 |
| Konopliannikov, AG | 1 |
| Kudriavtseva, GT | 1 |
| Zykov, AP | 1 |
| Poliakov, PIu | 2 |
| Kiseleva, ES | 1 |
| Kuznetsova, IP | 1 |
| Dar'ialova, SL | 2 |
| Dilkes, MG | 1 |
| Morrison, GA | 1 |
| Orr, WP | 1 |
| Borneff, M | 1 |
| Hartmetz, G | 1 |
| Roser, F | 1 |
| Geyer, G | 1 |
| Bleier, R | 1 |
| Anagnostou, M | 1 |
| Karakulov, RK | 1 |
| Pelevina, II | 1 |
| Zazovskiĭ, LM | 1 |
2 trials available for metronidazole and Pharyngeal Neoplasms
| Article | Year |
|---|---|
[Use of electron acceptor compounds in radiotherapy].
Topics: Clinical Trials as Topic; Esophageal Neoplasms; Female; Humans; Laryngeal Neoplasms; Metronidazole; | 1983 |
[Bacteriological, clinical, and pharmacokinetic studies of perioperative antibiotic prophylaxis in head and neck surgery].
Topics: Adult; Aged; Bacterial Infections; Female; Humans; Intraoperative Period; Laryngectomy; Male; Metron | 1987 |
3 other studies available for metronidazole and Pharyngeal Neoplasms
| Article | Year |
|---|---|
[Optimization of methods of radiotherapy of cancer of the tongue, mouth mucosa and oropharynx].
Topics: Adolescent; Adult; Humans; Hyperbaric Oxygenation; Methods; Metronidazole; Middle Aged; Mouth Neopla | 1982 |
Rare presentation of a parapharyngeal schwannoma.
Topics: Airway Obstruction; Dexamethasone; Erythromycin; Female; Humans; Metronidazole; Middle Aged; Neurile | 1991 |
[Use of the indicators of the proliferative activity of tumors of the oropharyngeal area as qualitative prognostic criteria of the radiotherapy].
Topics: Brachytherapy; Carcinoma, Squamous Cell; Humans; Hyperbaric Oxygenation; Metronidazole; Mouth Neopla | 1986 |