metronidazole and allopurinol

metronidazole has been researched along with allopurinol in 30 studies

Research

Studies (30)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (23.33)	18.7374
1990's	2 (6.67)	18.2507
2000's	11 (36.67)	29.6817
2010's	9 (30.00)	24.3611
2020's	1 (3.33)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Abraham, MH; Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Gugler, R	1
Chong, H	1
Beaulieu, BB; Chrystal, EJ; Goldman, P; Koch, RL; McLafferty, MA; Sudlow, G; Yeung, TC	1
Fried, LW; Fried, R	1
Fried, R	1
Goodhue, WW	1
Chrystal, EJ; Goldman, P; Koch, RL	1
Hummel, B; Lacey, S; Lichtman, SN; Sartor, RB; Wang, J	1
Schepetkin, IA	1
Britti, D; De Majo, M; Del Maso, R; Masucci, M; Pennisi, MG; Vitale, F	1
Argüello-García, R; González-Hernández, I; Jung-Cook, H; Ortega-Pierres, MG; Pech-Santiago, EO; Rafferty, SP; Saavedra, E; Vázquez, C	1

Reviews

2 review(s) available for metronidazole and allopurinol

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Oriental sore. A look at trends in and approaches to the treatment of leishmaniasis. International journal of dermatology, 1986, Volume: 25, Issue:10 Topics: Allopurinol; Aminoquinolines; Antimony; Antimony Sodium Gluconate; Cryosurgery; Humans; Leishmaniasis; Leishmaniasis, Mucocutaneous; Levamisole; Liposomes; Meglumine; Meglumine Antimoniate; Metronidazole; Nifurtimox; Organometallic Compounds; Phenothiazines; Rifampin	1986

Article

Year

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.

Drug discovery today, 2016, Volume: 21, Issue:4

Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Oriental sore. A look at trends in and approaches to the treatment of leishmaniasis.

International journal of dermatology, 1986, Volume: 25, Issue:10

Topics: Allopurinol; Aminoquinolines; Antimony; Antimony Sodium Gluconate; Cryosurgery; Humans; Leishmaniasis; Leishmaniasis, Mucocutaneous; Levamisole; Liposomes; Meglumine; Meglumine Antimoniate; Metronidazole; Nifurtimox; Organometallic Compounds; Phenothiazines; Rifampin

1986

Trials

1 trial(s) available for metronidazole and allopurinol

Article	Year
Efficacy of the treatment of dogs with leishmaniosis with a combination of metronidazole and spiramycin. The Veterinary record, 2005, Mar-12, Volume: 156, Issue:11 Topics: Allopurinol; Animals; Antiprotozoal Agents; Dog Diseases; Dogs; Drug Therapy, Combination; Female; Fluorescent Antibody Technique, Indirect; Leishmania infantum; Leishmaniasis, Visceral; Male; Meglumine; Metronidazole; Polymerase Chain Reaction; Spiramycin; Treatment Outcome	2005

Article

Year

Efficacy of the treatment of dogs with leishmaniosis with a combination of metronidazole and spiramycin.

The Veterinary record, 2005, Mar-12, Volume: 156, Issue:11

Topics: Allopurinol; Animals; Antiprotozoal Agents; Dog Diseases; Dogs; Drug Therapy, Combination; Female; Fluorescent Antibody Technique, Indirect; Leishmania infantum; Leishmaniasis, Visceral; Male; Meglumine; Metronidazole; Polymerase Chain Reaction; Spiramycin; Treatment Outcome

2005

Other Studies

27 other study(ies) available for metronidazole and allopurinol

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogPoct: a tool for lipophilicity determination in drug discovery. Journal of medicinal chemistry, 2000, Jul-27, Volume: 43, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Solvents	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
[Drug interactions in therapy using coumarin derivatives]. Der Internist, 1979, Volume: 20, Issue:5 Topics: Allopurinol; Anti-Inflammatory Agents; Barbiturates; Biological Availability; Cholestyramine Resin; Coumarins; Drug Interactions; Humans; Metronidazole; Phenylbutazone; Rifampin; Sulfonamides; Tolbutamide	1979
Comparing the reduction of nitroimidazoles in bacteria and mammalian tissues and relating it to biological activity. Biochemical pharmacology, 1986, Jan-01, Volume: 35, Issue:1 Topics: Animals; Bacteria, Anaerobic; Biotransformation; Cecum; DNA Repair; Enterobacteriaceae; Germ-Free Life; Humans; Metronidazole; Mutation; Nitroimidazoles; Oxidation-Reduction; Structure-Activity Relationship; Xanthine Oxidase	1986
Inhibition of oxidizing enzymes by metronidazole. Experientia, 1968, Jan-15, Volume: 24, Issue:1 Topics: Alcohol Oxidoreductases; Chemical Phenomena; Chemistry; Metronidazole; NAD; Spectrophotometry; Urate Oxidase; Xanthine Oxidase	1968
[Biochemical studies on a new anti-alcoholic drug, metronidazole (Flagyl)]. Archivos de biologia y medicina experimentales, 1969, Volume: 3, Issue:Suppl 3 Topics: Alcohol Deterrents; Alcohol Oxidoreductases; Animals; Cattle; Chemical Phenomena; Chemistry; Ethanol; Humans; Kidney; Liver; Metronidazole; Urate Oxidase; Xanthine Oxidase	1969
Disulfiram-metronidazole (well identified) toxicity. The New England journal of medicine, 1969, Jun-26, Volume: 280, Issue:26 Topics: Disulfiram; Humans; Metronidazole; Psychoses, Substance-Induced; Xanthine Oxidase	1969
Metabolites from the reduction of metronidazole by xanthine oxidase. Molecular pharmacology, 1980, Volume: 18, Issue:1 Topics: Acetates; Amino Acids; Biotransformation; Metronidazole; Oxidation-Reduction; Xanthine Oxidase	1980
A rat model of ileal pouch-rectal anastomosis. Inflammatory bowel diseases, 1998, Volume: 4, Issue:3 Topics: Allopurinol; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Free Radical Scavengers; Metronidazole; Pouchitis; Proctocolectomy, Restorative; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Reproducibility of Results; Severity of Illness Index	1998
Lucigenin luminescence elicited by microsomes and its modulation by nitroazole compounds. IUBMB life, 1999, Volume: 48, Issue:5 Topics: Acridines; Animals; Cattle; Horses; Luminescent Measurements; Male; Metronidazole; Microsomes, Liver; NADH, NADPH Oxidoreductases; NADP; Oxidation-Reduction; Radiation-Sensitizing Agents; Rats; Rats, Wistar; Superoxide Dismutase; Triazoles; Xanthine Oxidase	1999
Giardia duodenalis: Flavohemoglobin is involved in drug biotransformation and resistance to albendazole. PLoS pathogens, 2022, Volume: 18, Issue:9 Topics: Albendazole; Animals; Anthelmintics; Biotransformation; Chromatography, Liquid; Cytochromes; Flavins; Giardia lamblia; Heme; Humans; Iron; Metronidazole; Mixed Function Oxygenases; Molecular Docking Simulation; RNA, Messenger; Sulfones; Sulfoxides; Superoxides; Tandem Mass Spectrometry; Trophozoites; Xanthine Oxidase; Xanthines	2022