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metronidazole and Glioma

metronidazole has been researched along with Glioma in 5 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
"Metronidazole, 1."1.27Feasibility study of combining metronidazole with chemotherapy. ( Bélanger, R; Crook, AF; Heringer, R; Hopkins, HS; Hugenholtz, H; Maroun, JA; Richard, MT; Stewart, DJ; Yan, RC; Young, V, 1983)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19905 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Stewart, DJ1
Maroun, JA1
Young, V1
Crook, AF1
Hopkins, HS1
Yan, RC1
Richard, MT1
Hugenholtz, H1
Bélanger, R1
Heringer, R1
Potapov, SL1
Karakulov, RK1
Kachkov, IA2
Pelevina, II2
Liass, FM1
Konradov, SA1
Vartanian, LP1
Rudenko, IIa1
Volchkov, VA1
Nelson, DF1
Urtasun, RC1
Saunders, WM1
Gutin, PH1
Sheline, GE1

Reviews

1 review available for metronidazole and Glioma

ArticleYear
Recent and current investigations of radiation therapy of malignant gliomas.
    Seminars in oncology, 1986, Volume: 13, Issue:1

    Topics: Brachytherapy; Brain; Brain Neoplasms; Bromodeoxyuridine; Carmustine; Glioma; Helium; Humans; Hyperb

1986

Other Studies

4 other studies available for metronidazole and Glioma

ArticleYear
Feasibility study of combining metronidazole with chemotherapy.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1983, Volume: 1, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Carcinoma, Sq

1983
[Sensitivity of human brain tumors to radiation and to the combined effect of metronidazole and radiation].
    Meditsinskaia radiologiia, 1982, Volume: 27, Issue:12

    Topics: Animals; Astrocytoma; Brain Neoplasms; Ependymoma; Glioma; Hemangioma; Humans; In Vitro Techniques;

1982
[Metronidazole in the large split-dose concentrated irradiation of malignant gliomas].
    Meditsinskaia radiologiia, 1980, Volume: 25, Issue:8

    Topics: Adult; Brain Neoplasms; Drug Evaluation; Glioma; Humans; Metronidazole; Radiation Tolerance; Radioth

1980
[The radiation therapy of experimental brain tumors by using the radiosensitizing preparation xanthobin (8-bromocaffeine)].
    Meditsinskaia radiologiia, 1989, Volume: 34, Issue:11

    Topics: Animals; Brain Neoplasms; Caffeine; Drug Evaluation, Preclinical; Glioma; Metronidazole; Neoplasm Tr

1989