Page last updated: 2024-10-31

metronidazole and Fascioliasis

metronidazole has been researched along with Fascioliasis in 6 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Fascioliasis: Liver disease caused by infections with parasitic flukes of the genus FASCIOLA, such as FASCIOLA HEPATICA.

Research Excerpts

ExcerptRelevanceReference
"Treatment with praziquantel followed by metronidazole and tinidazole reduced abnormalities in the liver and eosinophilia."1.36A case of probable mixed-infection with Clonorchis sinensis and Fasciola sp.: CT and parasitological findings. ( Choi, WH; Chu, JP; Kim, JJ; Kim, TY; Lee, YS; Oh, IH; Song, HO; Yun, JH, 2010)
"Human fascioliasis has been recently become a health problem in Alexandria and Dakahlia governorates."1.29A case of human fascioliasis in Qualyobia Governorate. ( Arafa, MM; Lashen, AH, 1993)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19903 (50.00)18.7374
1990's1 (16.67)18.2507
2000's1 (16.67)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kim, TY1
Lee, YS1
Yun, JH1
Kim, JJ1
Choi, WH1
Oh, IH1
Song, HO1
Chu, JP1
Mansour-Ghanaei, F1
Shafaghi, A1
Fallah, M1
Wahn, V1
Mehlhorn, H1
Arafa, MM1
Lashen, AH1
Nik-Akhtar, B1
Tabibi, V1
Perry, W1
Goldsmid, JM1
Gelfand, M1

Other Studies

6 other studies available for metronidazole and Fascioliasis

ArticleYear
A case of probable mixed-infection with Clonorchis sinensis and Fasciola sp.: CT and parasitological findings.
    The Korean journal of parasitology, 2010, Volume: 48, Issue:2

    Topics: Adult; Animals; Anthelmintics; Antibodies, Protozoan; Clonorchiasis; Clonorchis sinensis; Entamoeba

2010
The effect of metronidazole in treating human fascioliasis.
    Medical science monitor : international medical journal of experimental and clinical research, 2003, Volume: 9, Issue:10

    Topics: Adult; Anthelmintics; Antitrichomonal Agents; Benzimidazoles; Enzyme-Linked Immunosorbent Assay; Fas

2003
[Four kinds of parasites in an 8-year-old boy. Therapeutic effects of praziquantel against Fasciola hepatica].
    Deutsche medizinische Wochenschrift (1946), 1984, Sep-28, Volume: 109, Issue:39

    Topics: Ascariasis; Child; Entamoeba histolytica; Entamoebiasis; Fasciola hepatica; Fascioliasis; Feces; Gia

1984
A case of human fascioliasis in Qualyobia Governorate.
    Journal of the Egyptian Society of Parasitology, 1993, Volume: 23, Issue:2

    Topics: Adult; Colon, Sigmoid; Egypt; Fascioliasis; Humans; Male; Metronidazole; Sigmoidoscopy

1993
Metronidazole in fascioliasis: report of four cases.
    The Journal of tropical medicine and hygiene, 1977, Volume: 80, Issue:8

    Topics: Adult; Child; Fasciola hepatica; Fascioliasis; Female; Humans; Male; Metronidazole; Middle Aged

1977
Human fascioliasis in Rhodesia. Report of a case with a liver abscess.
    The Journal of tropical medicine and hygiene, 1972, Volume: 75, Issue:11

    Topics: Abdomen; Biopsy; Child; Drainage; Emetine; Fasciola; Fascioliasis; Female; Humans; Liver; Liver Absc

1972