metronidazole has been researched along with Peripheral Nervous System Diseases in 39 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Peripheral Nervous System Diseases: Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 34-year-old Hispanic man with cirrhosis and hepatitis C being treated with metronidazole for Bacteroides fragilis meningitis and bacteremia developed ataxia, disorientation, and peripheral neuropathy." | 3.70 | Toxic metronidazole-induced MRI changes. ( Horlen, CK; Malouf, CS; Seifert, CF, 2000) |
| "In this case of painful legs and moving toes the essential characteristics were to be secondary to a neuropathy due to vincristine and metronidazole." | 3.67 | [Painful legs and moving toes. A drug-induced case]. ( Gastaut, JL, 1986) |
| "Here, we report a case of amoebic colitis in which peripheral neuropathy occurred approximately 24 hours after administering metronidazole." | 1.56 | [Early onset of metronidazole-induced peripheral neuropathy in a patient with amoebic colitis:a case report]. ( Hotta, Y; Ikeda, K; Isozaki, Y; Nagao, Y; Oaku, T; Oyamada, H; Sekoguchi, S; Takemura, K; Yamada, N; Yamane, S, 2020) |
| "Metronidazole was stopped." | 1.56 | Isolated involvement of corpus callosum in metronidazole-induced encephalopathy with concomitant peripheral neuropathy: A case report. ( Liu, S; Peng, Q; You, Q; Zhang, J, 2020) |
| "Metronidazole is a commonly used antimicrobial worldwide." | 1.48 | Reversible metronidazole-induced neurotoxicity after 10 weeks of therapy. ( AlDhaleei, W; AlMarzooqi, A; Gaber, N, 2018) |
| "Metronidazole can cause adverse effects both in the central and peripheral nervous system." | 1.40 | [Reversible neurotoxicity secondary to metronidazole: report of one case]. ( Galdames-Poblete, D; Retamal-Riquelme, E; Soto-San Martín, H; Vallejos-Castro, J, 2014) |
| "Axon degeneration is a feature of many peripheral neuropathies." | 1.40 | Peripheral glia have a pivotal role in the initial response to axon degeneration of peripheral sensory neurons in zebrafish. ( Pope, HM; Voigt, MM, 2014) |
| "Metronidazole was administrated for 5 weeks and symptoms were completely resolved." | 1.39 | Bacteroides fragilis vertebral osteomyelitis complicated by percutaneous epidural adhesiolysis. ( Choi, BK; Han, IH; Kim, SY; Nam, KH, 2013) |
| "Metronidazole is a widely prescribed treatment for amoebic and anaerobic germ infections." | 1.35 | [Metronidazole-induced reversible cerebellar lesions and peripheral neuropathy]. ( Essid, A; Hammouda, M; Laouani-Kechrid, C; Medimagh, L; Slamia, LB; Toumi, S, 2009) |
| "Fifty-three patients with Crohn's disease were chosen for this study." | 1.28 | Neurophysiologic studies of patients with Crohn's disease on long-term treatment with metronidazole. ( Bárány, F; Einarsson, K; Elmqvist, D; Persson, A; Ståhlberg, D; Ursing, B, 1991) |
| "Thirteen pediatric patients with Crohn's disease, aged 12-22 yr, were studied to assess the prevalence of peripheral neuropathy due to oral metronidazole." | 1.27 | Peripheral neuropathy in Crohn's disease patients treated with metronidazole. ( Aiges, HW; Daum, F; Duffy, LF; Fisher, SE; Markowitz, JF; Selman, J; Silverberg, M; Vishnubhakat, SM, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (33.33) | 18.7374 |
| 1990's | 8 (20.51) | 18.2507 |
| 2000's | 5 (12.82) | 29.6817 |
| 2010's | 10 (25.64) | 24.3611 |
| 2020's | 3 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Quickfall, D | 1 |
| Daneman, N | 1 |
| Dmytriw, AA | 1 |
| Juurlink, DN | 1 |
| Oaku, T | 1 |
| Yamada, N | 1 |
| Ikeda, K | 1 |
| Yamane, S | 1 |
| Takemura, K | 1 |
| Hotta, Y | 1 |
| Sekoguchi, S | 1 |
| Isozaki, Y | 1 |
| Nagao, Y | 1 |
| Oyamada, H | 1 |
| Peng, Q | 1 |
| You, Q | 1 |
| Zhang, J | 1 |
| Liu, S | 1 |
| Goolsby, TA | 1 |
| Jakeman, B | 1 |
| Gaynes, RP | 1 |
| AlDhaleei, W | 1 |
| AlMarzooqi, A | 1 |
| Gaber, N | 1 |
| Diodato, D | 1 |
| Olivieri, G | 1 |
| Pro, S | 1 |
| Maiorani, D | 1 |
| Martinelli, D | 1 |
| Deodato, F | 1 |
| Taurisano, R | 1 |
| Di Capua, M | 1 |
| Dionisi-Vici, C | 1 |
| Carroll, MW | 1 |
| Jeon, D | 1 |
| Mountz, JM | 1 |
| Lee, JD | 1 |
| Jeong, YJ | 1 |
| Zia, N | 1 |
| Lee, M | 1 |
| Lee, J | 1 |
| Via, LE | 1 |
| Lee, S | 1 |
| Eum, SY | 1 |
| Lee, SJ | 1 |
| Goldfeder, LC | 1 |
| Cai, Y | 1 |
| Jin, B | 1 |
| Kim, Y | 1 |
| Oh, T | 1 |
| Chen, RY | 1 |
| Dodd, LE | 1 |
| Gu, W | 1 |
| Dartois, V | 1 |
| Park, SK | 1 |
| Kim, CT | 1 |
| Barry, CE | 1 |
| Cho, SN | 1 |
| Retamal-Riquelme, E | 1 |
| Soto-San Martín, H | 1 |
| Vallejos-Castro, J | 1 |
| Galdames-Poblete, D | 1 |
| Pope, HM | 1 |
| Voigt, MM | 1 |
| Batjom, E | 1 |
| Franck, L | 1 |
| Dubost, C | 1 |
| Rouquette-Vincenti, I | 1 |
| Toumi, S | 1 |
| Hammouda, M | 1 |
| Essid, A | 1 |
| Medimagh, L | 1 |
| Slamia, LB | 1 |
| Laouani-Kechrid, C | 1 |
| Etxeberria, A | 1 |
| Lonneville, S | 1 |
| Rutgers, MP | 1 |
| Gille, M | 1 |
| Lambert, AM | 1 |
| Bonkowsky, JL | 1 |
| Masino, MA | 1 |
| Matsumoto, H | 1 |
| Ugawa, Y | 1 |
| Han, IH | 1 |
| Choi, BK | 1 |
| Nam, KH | 1 |
| Kim, SY | 1 |
| Rustscheff, S | 1 |
| Hulten, S | 1 |
| Sarma, GR | 1 |
| Kamath, V | 1 |
| Desbordes, JM | 1 |
| Maissin, F | 1 |
| Bataille, B | 1 |
| Desplat, A | 1 |
| Roualdes, G | 1 |
| Becq-Giraudon, B | 1 |
| Pais, P | 1 |
| Balasubramaniam, KR | 1 |
| Snavely, SR | 1 |
| Hodges, GR | 1 |
| Learned-Coughlin, S | 1 |
| Porterfield, LM | 1 |
| Dreger, LM | 1 |
| Gleason, PP | 1 |
| Chowdhry, TK | 1 |
| Gazzuolo, DJ | 1 |
| Brieva, L | 1 |
| Ara, JR | 1 |
| Bertol, V | 1 |
| Canellas, A | 1 |
| del Agua, C | 1 |
| Sathi, N | 1 |
| Shinton, RA | 1 |
| Horlen, CK | 1 |
| Seifert, CF | 1 |
| Malouf, CS | 1 |
| Coxon, A | 1 |
| Pallis, CA | 1 |
| Bradley, WG | 1 |
| Karlsson, IJ | 1 |
| Rassol, CG | 1 |
| Lagueny, A | 1 |
| Vallat, JM | 1 |
| Lamouliate, H | 1 |
| Dubarry, JJ | 1 |
| Livengood, CH | 1 |
| Lossick, JG | 1 |
| Ståhlberg, D | 1 |
| Bárány, F | 1 |
| Einarsson, K | 1 |
| Ursing, B | 1 |
| Elmqvist, D | 1 |
| Persson, A | 1 |
| Boyce, EG | 1 |
| Cookson, ET | 1 |
| Bond, WS | 1 |
| Takeuchi, H | 2 |
| Yamada, A | 2 |
| Touge, T | 2 |
| Miki, H | 2 |
| Nishioka, M | 1 |
| Hashimoto, S | 2 |
| Duffy, LF | 1 |
| Daum, F | 1 |
| Fisher, SE | 1 |
| Selman, J | 1 |
| Vishnubhakat, SM | 1 |
| Aiges, HW | 1 |
| Markowitz, JF | 1 |
| Silverberg, M | 1 |
| Berstad, J | 1 |
| Pieris, EV | 1 |
| Gastaut, JL | 1 |
| Ramsay, ID | 1 |
2 reviews available for metronidazole and Peripheral Nervous System Diseases
| Article | Year |
|---|---|
Clinical relevance of metronidazole and peripheral neuropathy: a systematic review of the literature.
Topics: Anti-Infective Agents; Humans; Incidence; Metronidazole; Peripheral Nervous System Diseases | 2018 |
The neurotoxicity of antibacterial agents.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Central Nervous System Disea | 1984 |
1 trial available for metronidazole and Peripheral Nervous System Diseases
| Article | Year |
|---|---|
Efficacy and safety of metronidazole for pulmonary multidrug-resistant tuberculosis.
Topics: Adult; Antitubercular Agents; Area Under Curve; Confidence Intervals; Double-Blind Method; Female; H | 2013 |
36 other studies available for metronidazole and Peripheral Nervous System Diseases
| Article | Year |
|---|---|
Metronidazole-induced neurotoxicity.
Topics: Anti-Infective Agents; Humans; Metronidazole; Neurotoxicity Syndromes; Peripheral Nervous System Dis | 2021 |
[Early onset of metronidazole-induced peripheral neuropathy in a patient with amoebic colitis:a case report].
Topics: Aged; Antiprotozoal Agents; Dysentery, Amebic; Gastrointestinal Hemorrhage; Humans; Male; Metronidaz | 2020 |
Isolated involvement of corpus callosum in metronidazole-induced encephalopathy with concomitant peripheral neuropathy: A case report.
Topics: Adult; Aged; Antiprotozoal Agents; Brain Diseases; Corpus Callosum; Dysentery, Amebic; Humans; Magne | 2020 |
Reversible metronidazole-induced neurotoxicity after 10 weeks of therapy.
Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; beta-Lactamase Inhibito | 2018 |
Axonal peripheral neuropathy in propionic acidemia: A severe side effect of long-term metronidazole therapy.
Topics: Adolescent; Child; Humans; Metronidazole; Peripheral Nervous System Diseases; Propionic Acidemia | 2018 |
[Reversible neurotoxicity secondary to metronidazole: report of one case].
Topics: Adult; Antiprotozoal Agents; Cerebellar Diseases; Female; Humans; Liver Abscess; Magnetic Resonance | 2014 |
Peripheral glia have a pivotal role in the initial response to axon degeneration of peripheral sensory neurons in zebrafish.
Topics: Animals; Animals, Genetically Modified; Axons; Bacterial Proteins; Cell Death; Disease Models, Anima | 2014 |
[When an antibiotic becomes toxic].
Topics: Aged; Anti-Bacterial Agents; Diverticulitis, Colonic; Female; Humans; Metronidazole; Peripheral Nerv | 2009 |
[Metronidazole-induced reversible cerebellar lesions and peripheral neuropathy].
Topics: Adult; Brain Abscess; Cerebellar Diseases; Consciousness Disorders; Humans; Magnetic Resonance Imagi | 2009 |
Metronidazole-cerebellopathy associated with peripheral neuropathy, downbeat nystagmus, and bilateral ocular abduction deficit.
Topics: Abducens Nerve Diseases; Accommodation, Ocular; Aged, 80 and over; Anti-Infective Agents; Cerebellar | 2012 |
The conserved dopaminergic diencephalospinal tract mediates vertebrate locomotor development in zebrafish larvae.
Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Diencephalon; Dopamine; Dopamine Agent | 2012 |
[Drug induced peripheral neuropathy].
Topics: Amiodarone; Anti-Arrhythmia Agents; Anti-HIV Agents; Antibodies, Monoclonal; Anticonvulsants; Antine | 2012 |
Bacteroides fragilis vertebral osteomyelitis complicated by percutaneous epidural adhesiolysis.
Topics: Adult; Anti-Bacterial Agents; Bacteroides fragilis; Bacteroides Infections; Ceftazidime; Combined Mo | 2013 |
An unexpected and severe neurological disorder with permanent disability acquired during short-course treatment with metronidazole.
Topics: Chronic Disease; Disability Evaluation; Female; Follow-Up Studies; Humans; Metronidazole; Middle Age | 2003 |
Acute painful peripheral neuropathy due to metronidazole.
Topics: Anti-Infective Agents; Female; Humans; Metronidazole; Middle Aged; Neuralgia; Peripheral Nervous Sys | 2005 |
[Peripheral neuropathy during treatment with ornidazole].
Topics: Adolescent; Critical Care; Follow-Up Studies; Humans; Male; Metronidazole; Nitroimidazoles; Ornidazo | 1984 |
Metronidazole-peripheral neuropathy.
Topics: Adult; Humans; Liver Abscess, Amebic; Male; Metronidazole; Peripheral Nervous System Diseases | 1982 |
Peripheral neuropathy induced by metronidazole.
Topics: Aged; Aged, 80 and over; Gastritis; Helicobacter Infections; Helicobacter pylori; Humans; Male; Metr | 1994 |
A serious side effect for a commonly prescribed antibiotic.
Topics: Adult; Female; Humans; Metronidazole; Patient Education as Topic; Peripheral Nervous System Diseases | 1996 |
Intermittent-dose metronidazole-induced peripheral neuropathy.
Topics: Aged; Anti-Infective Agents; Female; Humans; Metronidazole; Peripheral Nervous System Diseases | 1998 |
[Polyneuropathy caused by vitamin B12 deficiency secondary to chronic atrophic gastritis and giardiasis].
Topics: Amoxicillin; Anemia, Pernicious; Anti-Bacterial Agents; Antiprotozoal Agents; Bismuth; Duodenitis; E | 1998 |
An elderly man with dysphasia and pyrexia.
Topics: Aged; Aged, 80 and over; Anti-Infective Agents; Aphasia; Brain Abscess; Fever; Humans; Male; Metroni | 1999 |
Toxic metronidazole-induced MRI changes.
Topics: Adult; Anti-Infective Agents; Brain; Hepatitis C; Humans; Liver Cirrhosis; Magnetic Resonance Imagin | 2000 |
Metronidazole neuropathy.
Topics: Adult; Crohn Disease; Diagnosis, Differential; Electrodiagnosis; Female; Humans; Male; Metronidazole | 1976 |
Metronidazole neuropathy.
Topics: Adult; Animals; Crohn Disease; Humans; Male; Metronidazole; Peripheral Nervous System Diseases; Rats | 1977 |
[Sensory neuropathy and metronidazole. Apropos of a recent case with ultrastructural study].
Topics: Adult; Humans; Male; Metronidazole; Peripheral Nerves; Peripheral Nervous System Diseases | 1977 |
Resolution of resistant vaginal trichomoniasis associated with the use of intravaginal nonoxynol-9.
Topics: Adult; Chronic Disease; Contraceptive Agents; Drug Resistance, Microbial; Female; Humans; Metronidaz | 1991 |
Neurophysiologic studies of patients with Crohn's disease on long-term treatment with metronidazole.
Topics: Adult; Aged; Crohn Disease; Evoked Potentials; Female; Humans; Male; Metronidazole; Middle Aged; Neu | 1991 |
Persistent metronidazole-induced peripheral neuropathy.
Topics: Adult; Crohn Disease; Female; Humans; Metronidazole; Peripheral Nervous System Diseases | 1990 |
Metronidazole neuropathy: a case report.
Topics: Aged; Axons; Biopsy; Electromyography; Humans; Liver Abscess, Amebic; Male; Metronidazole; Muscles; | 1988 |
Peripheral neuropathy in Crohn's disease patients treated with metronidazole.
Topics: Administration, Oral; Adolescent; Adult; Child; Cranial Nerves; Crohn Disease; Electric Stimulation; | 1985 |
[Metronidazole (Flagyl) and polyneuropathy].
Topics: Humans; Male; Metronidazole; Middle Aged; Neural Conduction; Peripheral Nervous System Diseases | 1985 |
Sensori-motor metronidazole neuropathy.
Topics: Colitis; Humans; Metronidazole; Peripheral Nervous System Diseases | 1985 |
[Painful legs and moving toes. A drug-induced case].
Topics: Adult; Drug Interactions; Humans; Leg; Male; Metronidazole; Movement Disorders; Pain; Peripheral Ner | 1986 |
[Metronidazole neuropathy].
Topics: Aged; Humans; Liver Abscess, Amebic; Male; Metronidazole; Peripheral Nervous System Diseases | 1987 |
Endocrine ophthalmopathy.
Topics: Adult; Female; Graves Disease; Humans; Metronidazole; Peripheral Nervous System Diseases | 1968 |