metronidazole has been researched along with Arthritis, Juvenile Chronic in 1 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We experienced a 13 year-old male who was taking low-dose methotrexate for juvenile rheumatoid arthritis complained diarrhea and abdominal pain for 3 weeks." | 3.76 | [A case of pseudomembranous colitis in a juvenile rheumatoid arthritis patient taking methotrexate]. ( Ahn, HJ; Choi, KY; Kim, NY; Kim, SW; Lee, HM; Lee, HN; Yu, JH, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yu, JH | 1 |
| Kim, NY | 1 |
| Lee, HM | 1 |
| Lee, HN | 1 |
| Ahn, HJ | 1 |
| Kim, SW | 1 |
| Choi, KY | 1 |
1 other study available for metronidazole and Arthritis, Juvenile Chronic
| Article | Year |
|---|---|
[A case of pseudomembranous colitis in a juvenile rheumatoid arthritis patient taking methotrexate].
Topics: Abdominal Pain; Adolescent; Anti-Infective Agents; Antirheumatic Agents; Arthritis, Juvenile; Diagno | 2010 |