Pott Puffy Tumor

Infection of the FRONTAL BONE often as a complication of FRONTAL SINUSITIS or trauma to the frontal bone and skull. It is characterized by subperiosteal abscess with OSTEOMYELITIS.

Synonym
Pott's Puffy Tumor
Pott Puffy Tumor

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	8 (88.89)	28.8240
2020's	1 (11.11)	9.53

Drug	Relationship Strength	Studies
metronidazole	low	2
penicillin g	low	1
betamethasone	low	1
vancomycin	low	2
amoxicillin	low	1
betamethasone sodium phosphate	low	1
moxifloxacin	low	1
meropenem	low	2
amoxicillin-potassium clavulanate combination	low	1
ro13-9904	low	3

Protein Targets (199)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	1	0	0	1
Chain A, Beta-lactamase	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	2
AR protein	4	0	0	4
apical membrane antigen 1, AMA1	1	0	0	1
estrogen nuclear receptor alpha	5	0	0	5
Beta-lactamase	0	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	2	0	0	2
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
DNA polymerase kappa isoform 1	1	0	0	1
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	4
Bile salt export pump	0	1	0	1
Bile salt export pump	0	6	0	6
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase SHV-1	0	0	0	3
Cytochrome P450 2C9	0	1	0	1
Beta-lactamase	0	0	0	3
Kappa-type opioid receptor	0	0	0	2
Solute carrier family 15 member 1	0	2	0	2
Solute carrier family 15 member 1	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
B2 metallo-beta-lactamase	0	0	0	3
Solute carrier family 15 member 2	0	2	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	2	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Canalicular multispecific organic anion transporter 1	0	4	0	4
pregnane X receptor	2	0	0	2
GLI family zinc finger 3	3	0	0	3
progesterone receptor	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	1	0	0	1
glucocorticoid receptor [Homo sapiens]	3	0	0	3
estrogen-related nuclear receptor alpha	4	0	0	4
farnesoid X nuclear receptor	2	0	0	2
pregnane X nuclear receptor	4	0	0	4
vitamin D (1,25- dihydroxyvitamin D3) receptor	1	0	0	1
IDH1	1	0	0	1
aryl hydrocarbon receptor	4	0	0	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	3	0	0	3
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
thyroid hormone receptor beta isoform a	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
galanin receptor type 3	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	3	0	0	3
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Glucocorticoid receptor	0	2	0	2
Glycine receptor subunit alpha-1	0	2	0	2
Glutamate receptor 2	3	0	0	3
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
ORF73	0	0	1	1
peroxisome proliferator activated receptor gamma	2	0	0	2
thyroid hormone receptor beta isoform 2	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	2	0	0	2
G	1	0	0	1
Beta-lactamase	0	0	0	2
peroxisome proliferator-activated receptor delta	2	0	0	2
Metallo-beta-lactamase type 2	0	0	1	3
Metallo-beta-lactamase VIM-11	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Metallo-beta-lactamase VIM-19	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase	0	0	0	2
streptokinase A precursor	0	0	2	2
lethal factor (plasmid)	1	0	0	1
Interferon beta	1	0	0	1
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase TEM	0	1	0	3
Metallo-beta-lactamase VIM-13	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	1	3
Metallo-b-lactamase	0	0	0	2
Beta-lactamase IMP-1	0	0	0	2
BlaVIM-1	0	0	0	2
Inositol hexakisphosphate kinase 1	1	0	0	1
Beta-lactamase	0	0	0	2
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	2
Histamine H3 receptor	0	0	0	1
Beta-lactamase class B VIM-2	0	0	1	3
Beta-lactamase	0	0	0	2
Beta-lactamase VIM-1	0	0	0	2
cytochrome P450 2C9, partial	1	0	0	1
TDP1 protein	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
EWS/FLI fusion protein	1	0	0	1
Thioredoxin reductase	0	1	0	1
Histone H2A.x	1	0	0	1
vitamin D3 receptor isoform VDRA	2	0	0	2
mitogen-activated protein kinase 1	1	0	0	1
geminin	1	0	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
lamin isoform A-delta10	1	0	0	1
Flavodoxin	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Cellular tumor antigen p53	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
TAR DNA-binding protein 43	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Lanosterol 14-alpha demethylase	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Cytochrome P450 3A4	0	2	0	2
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	2
DNA gyrase subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
DNA topoisomerase 2-alpha	0	0	0	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Spike glycoprotein	1	0	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	1	0	2
Potassium voltage-gated channel subfamily H member 2	0	1	0	2
Sodium channel protein type 5 subunit alpha	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Chain A, Ferritin light chain	1	0	0	1
glp-1 receptor, partial	1	0	0	1
phosphopantetheinyl transferase	1	0	0	1
RAR-related orphan receptor gamma	1	0	0	1
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
estrogen receptor 2 (ER beta)	1	0	0	1
nonstructural protein 1	1	0	0	1
retinoic acid nuclear receptor alpha variant 1	1	0	0	1
retinoid X nuclear receptor alpha	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
chromobox protein homolog 1	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
nuclear receptor ROR-gamma isoform 1	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Histamine H2 receptor	1	0	0	1
ATPase family AAA domain-containing protein 5	1	0	0	1
Ataxin-2	1	0	0	1
heat shock protein 90, putative	0	0	0	1
Albumin	0	0	1	1
Alpha-2A adrenergic receptor	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Transporter	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research

Studies (9)

Protein Targets (199)

Pott Puffy Tumor

Synonyms(2)

Research

Studies (9)

Drugs Studied (11)

Protein Targets (199)