Pyogenic Sacroiliitis

Inflammation of the SACROILIAC JOINT. It is characterized by lower back pain, especially upon walking, fever, UVEITIS; PSORIASIS; and decreased range of motion. Many factors are associated with and cause sacroiliitis including infection; injury to spine, lower back, and pelvis; DEGENERATIVE ARTHRITIS; and pregnancy.

Synonym
Sacroiliitis
Pyogenic Sacroiliitis
Septic Sacroiliitis

Excerpt	Reference
"GBS sacroiliitis is a rare form of septic sacroiliitis requiring prompt diagnosis and urgent treatment."	( Chen, S; Cheng, TK; Ho, CL; Leung, YL; Wu, WC, 2010)
"Septic sacroiliitis is an uncommon infection of immunocompetent patients, typically caused by gram-positive bacteria, with fewer gram-negative cases, and only 5% attributed to Pseudomonas species."	( Akers, KS; Alderete, JF; Lindholm, DA; Murray, CK; O'Brien, SD; Vento, TJ, 2013)
"Sacroiliitis is associated with increased vascular inflammation detected by FDG-PET/CT, suggesting that sacroiliac joint disease may identify patients at greater risk for CVD."	( Dave, J; Mehta, NN; Millo, C; Naik, HB; Rose, S; Siegel, EL, 2014)
"Pyogenic sacroiliitis is by far the most common cause of acute sacroiliitis."	( Boulman, N; Kaly, L; Odeh, M; Rimar, D; Rosner, I; Rozenbaum, M; Slobodin, G, 2016)
"Infective sacroiliitis is rare and only represents 1%-2% of septic arthritis in children."	( Monem, M; Patel, R; Sherief, T, 2017)
"Sacroiliitis is underdiagnosed in IBD and is associated with male sex, arthritis, and inflammatory CD."	( Chan, J; Inman, RD; Kelly, OB; Li, N; Silverberg, MS; Smith, M, 2019)
"Sacroiliitis is one of the extraintestinal manifestation associated with IBD; it is often asymptomatic and clinically underdetected, with an unrelated progression with respect to the underlying IBD."	( Basile, M; Bernardini, A; Cimaz, R; Di Maurizo, M; Filistrucchi, V; Giani, T; Lionetti, P; Perrone, A; Renzo, S, 2020)
"Sacroiliitis is commonly seen in enthesitis-related arthritis (ERA), a subtype of juvenile idiopathic arthritis (JIA)."	( Amaral, J; Chamlati, R; Connolly, B; Laxer, R; Muthusami, P; Panwar, J; Parra, DA; Stimec, J; Temple, M; Tse, S, 2020)
"Sacroiliitis is one of these side effects and has been rarely reported in the children."	( Baglan, E; Bulbul, M; Celikkaya, E; Kargın Cakıcı, E; Ozdel, S; Yazılıtas, F, 2020)

Excerpt	Reference
"GBS sacroiliitis is a rare form of septic sacroiliitis requiring prompt diagnosis and urgent treatment."	( Chen, S; Cheng, TK; Ho, CL; Leung, YL; Wu, WC, 2010)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	70 (67.96)	28.8240
2020's	33 (32.04)	9.53

Drug	Relationship Strength	Studies	Trials
uric acid	low	3	0
acemetacin	low	1	0
bupivacaine	low	1	0
celecoxib	low	1	0
ciprofloxacin	low	4	0
glyphosate	low	2	0
indomethacin	low	1	0
mesalamine	low	1	0
metronidazole	low	1	0
ofloxacin	low	3	0
sulfasalazine	low	2	0
thalidomide	low	3	0
prednisone	low	1	0
colchicine	low	4	0
triamcinolone acetonide	low	1	0
meglumine	low	1	0
nafcillin	low	1	0
thiazoles	low	1	0
ethambutol	low	1	0
vancomycin	low	3	0
streptomycin	low	1	0
triamcinolone hexacetonide	low	1	0
technetium	low	4	0
titanium	low	1	0
gadolinium	low	5	0
tricalcium phosphate	low	1	0
ozone	low	1	0
trolamine salicylate	low	18	0
triamcinolone	low	1	0
fluorodeoxyglucose f18	low	2	0
zoledronic acid	low	1	0
6-amino-1-hydroxyhexane-1,1-diphosphonate	low	1	0
oxazolidin-2-one	low	1	0
clarithromycin	low	1	0
deoxypyridinoline	low	1	0
mk 0663	medium	3	1
methotrexate	low	10	0
levofloxacin	low	3	0
fibrin	low	1	0
linezolid	low	1	0
clindamycin	low	2	0
isotretinoin	low	15	0
andrographolide	low	1	0
tin	low	1	0
gadolinium dtpa	low	4	0
amoxicillin-potassium clavulanate combination	low	1	0
apremilast	low	2	0
imrecoxib	low	1	0
ro13-9904	low	8	0
mobic	low	1	0
transforming growth factor beta	low	1	0
rifampin	low	5	0

Protein Targets (629)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Geranylgeranyl pyrophosphate synthase	0	3	0	4
Farnesyl pyrophosphate synthase	0	4	0	4
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	8	0	0	8
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Chain A, Cruzipain	6	0	0	6
Luciferase	7	0	0	7
phosphopantetheinyl transferase	3	0	0	3
SMAD family member 2	6	0	0	6
SMAD family member 3	6	0	0	6
AR protein	15	0	0	15
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	7	0	0	7
estrogen nuclear receptor alpha	20	0	0	20
peroxisome proliferator-activated receptor delta	9	0	0	9
peroxisome proliferator activated receptor gamma	10	0	0	10
vitamin D (1,25- dihydroxyvitamin D3) receptor	12	0	0	12
chromobox protein homolog 1	5	0	0	5
pyruvate kinase PKM isoform a	1	0	0	1
Lactoylglutathione lyase	0	2	0	2
TAR DNA-binding protein 43	5	0	0	5
PPM1D protein	3	0	0	3
TDP1 protein	15	0	0	15
cytochrome P450 family 3 subfamily A polypeptide 4	10	0	0	10
G	6	0	0	6
67.9K protein	6	0	0	6
thyroid hormone receptor beta isoform 2	8	0	0	8
Interferon beta	8	0	0	8
HLA class I histocompatibility antigen, B alpha chain	6	0	0	6
Cellular tumor antigen p53	9	0	0	9
Replicase polyprotein 1ab	0	1	0	1
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Signal transducer and activator of transcription 3	0	0	1	1
Hexokinase-2	0	1	0	1
Inositol hexakisphosphate kinase 1	6	0	0	6
Bile acid receptor	0	1	0	1
cytochrome P450 2C9, partial	6	0	0	6
Cytochrome P450 1A2	0	3	0	4
Cytochrome P450 3A4	0	5	0	6
Cytochrome P450 2D6	0	4	0	5
Cytochrome P450 2C9	0	6	0	7
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Cytochrome P450 2C19	0	3	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Carboxylic ester hydrolase	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	0	1	1
Potassium channel subfamily K member 9	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	2	0	2
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
glp-1 receptor, partial	2	0	0	2
pregnane X receptor	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
RAR-related orphan receptor gamma	10	0	0	10
USP1 protein, partial	5	0	0	5
GLI family zinc finger 3	9	0	0	9
Smad3	3	0	0	3
caspase 7, apoptosis-related cysteine protease	1	0	0	1
thyroid stimulating hormone receptor	5	0	0	5
estrogen receptor 2 (ER beta)	7	0	0	7
progesterone receptor	8	0	0	8
EWS/FLI fusion protein	10	0	0	10
glucocorticoid receptor [Homo sapiens]	12	0	0	12
retinoic acid nuclear receptor alpha variant 1	7	0	0	7
retinoid X nuclear receptor alpha	11	0	0	11
estrogen-related nuclear receptor alpha	12	0	0	12
farnesoid X nuclear receptor	8	0	0	8
pregnane X nuclear receptor	10	0	0	10
cytochrome P450 2D6	4	0	0	4
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Rac1 protein	0	0	1	1
caspase-3	1	0	0	1
IDH1	4	0	0	4
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	8	0	0	8
thyroid stimulating hormone receptor	4	0	0	4
activating transcription factor 6	4	0	0	4
thyrotropin-releasing hormone receptor	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
Histone H2A.x	6	0	0	6
Caspase-7	2	0	0	2
interferon gamma precursor	0	0	0	1
prostaglandin E2 receptor EP2 subtype	0	0	0	1
thyroid hormone receptor beta isoform a	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 2	7	0	0	7
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
caspase-3	2	0	0	2
heat shock protein beta-1	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 1	11	0	0	11
geminin	12	0	0	12
peripheral myelin protein 22	4	0	0	4
cytochrome P450 3A4 isoform 1	4	0	0	4
lamin isoform A-delta10	12	0	0	12
Gamma-aminobutyric acid receptor subunit pi	4	2	0	6
Prostaglandin E synthase	0	2	0	2
Histone deacetylase 3	0	1	0	1
ATP-binding cassette sub-family C member 3	0	17	0	17
Multidrug resistance-associated protein 4	0	17	0	18
3-phosphoinositide-dependent protein kinase 1	0	1	0	1
Carbonic anhydrase 12	0	2	0	2
Prostaglandin G/H synthase 1	0	2	0	3
Prostaglandin G/H synthase 2	0	2	0	3
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Cytochrome c oxidase subunit 1	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	6	0	0	6
Bile salt export pump	0	20	0	20
Cytochrome c oxidase subunit 2	0	2	0	2
Carbonic anhydrase 1	0	6	0	6
Carbonic anhydrase 2	0	6	1	7
Prostaglandin G/H synthase 1	0	6	0	7
Carbonic anhydrase 3	0	1	0	1
Procathepsin L	0	2	0	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Quinolone resistance protein NorA	0	1	0	1
Adenosine receptor A3	0	4	0	4
Neuronal acetylcholine receptor subunit beta-2	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	4	2	0	6
Alpha-1B adrenergic receptor	0	5	0	5
Calpain-2 catalytic subunit	0	1	0	1
Alpha-2B adrenergic receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit delta	4	2	0	6
Gamma-aminobutyric acid receptor subunit gamma-2	4	2	0	6
5-hydroxytryptamine receptor 1A	0	1	0	1
Glutamate receptor 2	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	4	2	0	6
Gamma-aminobutyric acid receptor subunit alpha-3	4	2	0	6
D(1A) dopamine receptor	0	2	0	2
Prostaglandin G/H synthase 1	0	3	0	3
Carbonic anhydrase 4	0	1	0	1
Prostaglandin G/H synthase 1	0	5	0	6
Carbonic anhydrase 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	4	2	0	6
Gamma-aminobutyric acid receptor subunit alpha-2	4	2	0	6
Sodium-dependent noradrenaline transporter	0	2	0	2
Adenosine receptor A1	0	2	0	2
Cruzipain	0	1	0	1
Sodium/hydrogen exchanger 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	4	2	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	4	2	0	6
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	4	2	0	6
Sodium-dependent serotonin transporter	0	2	0	2
Sodium-dependent serotonin transporter	0	1	1	2
Delta-type opioid receptor	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	3	0	3
Bifunctional epoxide hydrolase 2	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Prostaglandin G/H synthase 2	0	8	2	11
Prostaglandin G/H synthase 2	0	2	0	2
Carbonic anhydrase	0	2	0	2
Alpha-1A adrenergic receptor	0	5	0	5
Carbonic anhydrase 7	0	1	0	1
Urotensin-2 receptor	0	1	0	1
Nuclear receptor ROR-gamma	4	0	0	4
Carbonic anhydrase	0	1	0	1
Histone deacetylase 4	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	4	3	0	7
Gamma-aminobutyric acid receptor subunit beta-3	4	2	0	6
Gamma-aminobutyric acid receptor subunit beta-2	4	2	0	6
Prostaglandin G/H synthase 2	0	6	0	6
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Prostaglandin G/H synthase 2	0	4	0	5
Histone deacetylase 1	0	1	0	1
Mitogen-activated protein kinase 14	0	3	0	3
Carbonic anhydrase 9	0	3	0	3
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Delta carbonic anhydrase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Carbonic anhydrase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Cyclooxygenase-2	0	1	0	1
Histone deacetylase 7	0	1	0	1
Rap guanine nucleotide exchange factor 4	3	0	0	3
GABA theta subunit	4	2	0	6
Histone deacetylase 2	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	15	0	15
Carbonic anhydrase 4	0	2	0	2
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
ATPase family AAA domain-containing protein 5	6	0	0	6
Ataxin-2	6	0	0	6
Carbonic anhydrase 15	0	1	0	1
Histone deacetylase 8	0	1	0	1
P2Y purinoceptor 12	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	4	2	0	6
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Carbonic anhydrase 14	0	2	0	2
Histone deacetylase 5	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
Chain A, 2-oxoglutarate Oxygenase	6	0	0	6
aldehyde dehydrogenase 1 family, member A1	11	0	0	11
cytochrome P450 2C9 precursor	5	0	0	5
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	3	0	6
DNA gyrase subunit B	0	3	0	6
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
DNA topoisomerase 2-alpha	0	1	0	4
DNA gyrase subunit A	0	1	0	2
Multidrug resistance protein MdtK	0	0	1	1
Histamine H2 receptor	6	0	0	6
DNA gyrase subunit B	0	3	0	4
DNA gyrase subunit A	0	4	0	5
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	4
Potassium voltage-gated channel subfamily H member 2	0	7	0	8
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	1	0	1
importin subunit beta-1 isoform 1	2	0	0	2
mitogen-activated protein kinase 1	2	0	0	2
snurportin-1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
streptokinase A precursor	0	0	4	4
ATP-dependent translocase ABCB1	0	3	1	6
Solute carrier organic anion transporter family member 1B3	0	7	0	10
Solute carrier organic anion transporter family member 1B1	0	7	0	9
Protein-arginine deiminase type-4	0	5	0	5
Chain A, Beta-lactamase	3	0	0	3
Chain A, Ferritin light chain	4	0	0	4
interleukin 8	3	0	0	3
endonuclease IV	1	0	0	1
PAX8	0	0	0	1
thioredoxin reductase	6	0	0	6
ATAD5 protein, partial	6	0	0	6
Fumarate hydratase	2	0	0	2
Thrombopoietin	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	6	0	0	6
polyprotein	2	0	0	2
glucocerebrosidase	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	12	0	0	12
aryl hydrocarbon receptor	5	0	0	5
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
cytochrome P450 2D6 isoform 1	2	0	0	2
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cellular tumor antigen p53 isoform a	2	0	0	2
cytochrome P450 2C19 precursor	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
flap endonuclease 1	3	0	0	3
ras-related protein Rab-9A	2	0	0	2
steroidogenic factor 1	0	1	0	1
muscleblind-like protein 1 isoform 1	4	0	0	4
caspase-1 isoform alpha precursor	3	0	0	3
muscarinic acetylcholine receptor M1	1	0	0	1
lethal factor (plasmid)	1	0	0	1
neuropeptide S receptor isoform A	2	0	0	2
Solute carrier family 22 member 3	0	1	0	1
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	1
Tubulin beta-4A chain	0	3	2	6
ATP-dependent translocase ABCB1	0	1	0	1
Tubulin beta chain	0	3	2	6
Tubulin alpha-3C chain	0	3	2	6
Serine/threonine-protein kinase pim-1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Tubulin alpha-1B chain	0	3	2	6
Tubulin alpha-4A chain	0	3	2	6
Tubulin beta-4B chain	0	3	2	6
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	3	2	6
Tubulin beta-2A chain	0	3	2	6
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	3	2	6
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	3	2	6
Tubulin alpha-1A chain	0	3	2	6
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	3	2	6
Tubulin beta-6 chain	0	3	2	6
Tubulin beta-2B chain	0	3	2	6
Tubulin beta-1 chain	0	3	2	6
ATP-dependent phosphofructokinase	2	0	0	2
Pantothenate synthetase	0	1	0	1
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Glutamine synthetase	0	1	0	1
Cytochrome P450 71B1	0	1	0	2
Glutamine synthetase	0	1	0	1
2-dehydro-3-deoxyphosphooctonate aldolase	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Microtubule-associated protein tau	5	0	0	5
Parkin	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
peripheral myelin protein 22 isoform 1	3	0	0	3
vitamin D3 receptor isoform VDRA	8	0	0	8
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	4	0	0	4
nuclear receptor ROR-gamma isoform 1	3	0	0	3
DNA polymerase kappa isoform 1	3	0	0	3
M-phase phosphoprotein 8	2	0	0	2
Prostaglandin-H2 D-isomerase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	6	0	7
Epidermal growth factor receptor	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Albumin	0	1	4	5
Interleukin-8	0	1	0	1
Androgen receptor	0	0	1	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Thromboxane-A synthase	0	2	0	2
Serum paraoxonase/arylesterase 1	0	1	0	1
Caspase-1	0	2	0	3
Nitric oxide synthase, inducible	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Substance-P receptor	0	1	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	2
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Aldo-keto reductase family 1 member C3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Spike glycoprotein	5	0	0	5
Guanine nucleotide-binding protein G	1	0	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Aldo-keto reductase family 1 member C1	0	1	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Solute carrier family 22 member 6	0	1	0	3
Solute carrier family 22 member 7	0	0	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 8	0	2	0	3
Multidrug and toxin extrusion protein 1	0	2	0	2
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
regulator of G-protein signaling 4	1	0	0	1
Bloom syndrome protein isoform 1	4	0	0	4
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
serine/threonine-protein kinase PLK1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	1	0	1
Retinoic acid receptor gamma	0	1	0	1
Retinoic acid receptor beta	0	1	0	1
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	2	0	2
Retinoic acid receptor RXR-alpha	0	1	0	1
Retinoic acid receptor RXR-beta	0	1	0	1
Retinoic acid receptor RXR-gamma	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Cellular retinoic acid-binding protein 1	0	0	1	1
Olfactory receptor 51E2	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Replicase polyprotein 1ab	0	1	1	2
CAAX prenyl protease 2 isoform 2	0	0	0	1
DNA polymerase beta	2	0	0	2
histone acetyltransferase KAT2A isoform 1	4	0	0	4
Bile salt export pump	0	5	0	5
Fatty-acid amide hydrolase 1	0	1	0	1
DNA primase	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Estrogen receptor	0	0	1	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] A	0	2	0	2
Amine oxidase [flavin-containing] B	0	1	0	1
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
50S ribosomal protein L36 2	0	1	0	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
Estrogen receptor beta	0	0	1	1
Renin	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
15-lipoxygenase, partial	3	0	0	3
GLS protein	2	0	0	2
microphthalmia-associated transcription factor isoform 9	0	1	0	1
Tumor necrosis factor	0	1	1	2
Neuraminidase	0	1	0	1
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	3	0	3
Platelet-activating factor receptor	1	0	0	1
Cystathionine gamma-lyase	0	1	0	1
Caspase-7	2	0	0	2
10 kDa heat shock protein, mitochondrial	0	3	0	3
Thiosulfate sulfurtransferase	0	3	0	3
60 kDa chaperonin	0	3	0	3
10 kDa chaperonin	0	3	0	3
Cystine/glutamate transporter	0	2	0	2
Hydroxyacid oxidase 1	0	1	0	1
large T antigen	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	1	0	0	1
dopamine D1 receptor	1	0	0	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
alpha-galactosidase	2	0	0	2
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
survival motor neuron protein isoform d	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Integrin beta-3	1	0	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Integrin alpha-IIb	1	0	0	1
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	3	0	3
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	3
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
acetylcholinesterase	2	0	0	2
Glutathione reductase, mitochondrial	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
arylsulfatase A	3	0	0	3
STE24	0	0	0	1
CAAX prenyl protease	0	0	0	1
Trypsin	0	0	0	1
Vpr	1	0	0	1
thioredoxin glutathione reductase	2	0	0	2
Glucocorticoid receptor	0	6	1	7
Glycine receptor subunit alpha-1	0	6	0	6
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
DNA-directed RNA polymerase subunit beta	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Cytochrome P450 2B6	0	0	1	1
Arylacetamide deacetylase	0	1	0	2
Alpha-synuclein	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Eyes absent homolog 2	0	1	0	1
Carbonic anhydrase	0	1	0	1
Chain A, Glutathione S-transferase	0	1	0	1
histone deacetylase 9 isoform 3	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
Interstitial collagenase	0	1	0	1
Fibroblast growth factor 1	0	0	1	1
Androgen receptor	0	2	0	2
Flavin reductase (NADPH)	0	0	1	1
Cytochrome P450 2J2	0	2	0	2
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Sodium/bile acid cotransporter	0	1	0	1
Cereblon isoform 4	0	2	0	2
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
NFKB1 protein, partial	1	0	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Transporter	0	1	0	1
Butyrophilin subfamily 3 member A1	0	0	1	2
72 kDa type IV collagenase	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Neutrophil collagenase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Geranylgeranyl pyrophosphate synthase	0	2	0	2
Farnesyl pyrophosphate synthase	0	1	0	1
H	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(3)

Research Excerpts

Overview

Treatment

Research

Studies (103)

Protein Targets (629)

Pyogenic Sacroiliitis

Synonyms(3)

Research Excerpts

Overview

Treatment

Research

Studies (103)

Drugs Studied (58)

Protein Targets (629)