Page last updated: 2024-09-27

AIDS Enteropathy

A syndrome characterized by chronic, well-established DIARRHEA (greater than one month in duration) without an identified infectious cause after thorough evaluation, in an HIV-positive individual. It is thought to be due to direct or indirect effects of HIV on the enteric mucosa. HIV enteropathy is a diagnosis of exclusion and can be made only after other forms of diarrheal illness have been ruled out. (Harrison's Principles of Internal Medicine, 13th ed, pp1607-8; Haubrich et al., Bockus Gastroenterology, 5th ed, p1155)

Synonyms(8)

Synonym
Enteropathy, AIDS-Associated
HIV-Associated Enteropathy
Enteropathy, HIV-Associated
AIDS-Associated Enteropathy
HIV Enteropathy
AIDS Enteropathy
Enteropathy, HIV
Idiopathic AIDS Enteropathy

Research Excerpts

Research

Studies (23)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's13 (56.52)12.5806
2000's4 (17.39)18.1394
2010's6 (26.09)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
thiorphan0medium11
foscarnet0low10
gentamicin0low10
metronidazole0low20
glutamine0medium11
taurocholic acid0low30
stavudine0low10
barium sulfate0low10
zidovudine0low20
racecadotril0medium11
procyanidin0low20
23-seleno-25-homotaurocholic acid0low20
xylose0low10
curcumin0low10
indinavir sulfate0medium11
lactulose0low10
intrinsic factor0low10
vitamin b 120low10
rifampin0low10
didanosine0low10
cholestyramine resin0low30

Protein Targets (454)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Beta-lactamase1001
Luciferase3003
glp-1 receptor, partial1001
hypoxia-inducible factor 1 alpha subunit2002
RAR-related orphan receptor gamma2002
ATAD5 protein, partial4004
Fumarate hydratase1001
TDP1 protein6006
GLI family zinc finger 34004
AR protein4004
caspase 7, apoptosis-related cysteine protease3003
nuclear receptor subfamily 1, group I, member 34004
progesterone receptor2002
glucocorticoid receptor [Homo sapiens]5005
retinoic acid nuclear receptor alpha variant 14004
retinoid X nuclear receptor alpha5005
estrogen-related nuclear receptor alpha3003
farnesoid X nuclear receptor4004
pregnane X nuclear receptor5005
estrogen nuclear receptor alpha7007
polyprotein1001
67.9K protein3003
peroxisome proliferator activated receptor gamma3003
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
caspase-33003
IDH12002
euchromatic histone-lysine N-methyltransferase 27007
aryl hydrocarbon receptor3003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
v-jun sarcoma virus 17 oncogene homolog (avian)2002
nuclear receptor subfamily 1, group I, member 22002
Histone H2A.x4004
cellular tumor antigen p53 isoform a3003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
chromobox protein homolog 14004
nuclear factor erythroid 2-related factor 2 isoform 24004
transcriptional regulator ERG isoform 32002
thyroid hormone receptor beta isoform 24004
histone deacetylase 9 isoform 31001
heat shock protein beta-12002
mitogen-activated protein kinase 15005
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
geminin6006
Vif0102
peripheral myelin protein 223003
survival motor neuron protein isoform d2002
muscleblind-like protein 1 isoform 13003
DNA dC->dU-editing enzyme APOBEC-3G isoform 12103
lamin isoform A-delta105005
neuropeptide S receptor isoform A2002
ATP-binding cassette sub-family C member 30808
Multidrug resistance-associated protein 40909
Voltage-dependent calcium channel gamma-2 subunit2002
Bile salt export pump0809
Interferon beta4004
Cellular tumor antigen p534004
Integrin beta-33003
Integrin alpha-IIb3003
Methionine aminopeptidase0101
Glutamate receptor 22002
Fatty-acid amide hydrolase 10101
Inositol monophosphatase 12002
Canalicular multispecific organic anion transporter 10808
ATPase family AAA domain-containing protein 52002
Ataxin-22002
Carbonic anhydrase 10103
Carbonic anhydrase 20203
Carbonic anhydrase 40202
Carbonic anhydrase0101
Carbonic anhydrase 150101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, Breast cancer type 1 susceptibility protein1001
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Chain A, 2-oxoglutarate Oxygenase2002
Chain A, Ferritin light chain1001
Chain A, Cruzipain2002
interleukin 83003
acetylcholinesterase1001
Nrf21001
thioredoxin reductase3003
15-lipoxygenase, partial4004
pregnane X receptor1001
phosphopantetheinyl transferase4004
SMAD family member 22002
USP1 protein, partial2002
GLS protein2002
SMAD family member 32002
Microtubule-associated protein tau4004
alkaline phosphatase, intestinal0112
thioredoxin glutathione reductase2002
Smad32002
apical membrane antigen 1, AMA12002
aldehyde dehydrogenase 1 family, member A17007
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
PINK11001
thyroid stimulating hormone receptor3003
estrogen receptor 2 (ER beta)2002
EWS/FLI fusion protein4005
glucocerebrosidase2002
Parkin1001
bromodomain adjacent to zinc finger domain 2B2002
toll-like receptor 90101
peroxisome proliferator-activated receptor delta2002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
TPA: protein transporter TIM100101
thyroid stimulating hormone receptor1001
activating transcription factor 62002
thyrotropin-releasing hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
lysosomal alpha-glucosidase preproprotein2002
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein0112
hemoglobin subunit beta1001
polyunsaturated fatty acid lipoxygenase ALOX121001
perilipin-50101
vitamin D3 receptor isoform VDRA3003
intestinal alkaline phosphatase precursor0112
thyroid hormone receptor beta isoform a4004
perilipin-10101
potassium voltage-gated channel subfamily H member 2 isoform d1001
huntingtin isoform 21001
importin subunit beta-1 isoform 11001
pyruvate kinase PKM isoform a2002
DNA polymerase beta3003
nuclear factor NF-kappa-B p105 subunit isoform 11001
flap endonuclease 14004
snurportin-11001
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
nuclear factor erythroid 2-related factor 2 isoform 14004
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 11001
DNA polymerase iota isoform a (long)3003
nuclear receptor ROR-gamma isoform 12002
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
DNA polymerase kappa isoform 12002
cytochrome P450 3A4 isoform 12002
alkaline phosphatase, germ cell type preproprotein0112
caspase-1 isoform alpha precursor1001
hypothetical protein SA14220101
lethal factor (plasmid)1001
DNA dC->dU-editing enzyme APOBEC-3F isoform a2002
Gamma-aminobutyric acid receptor subunit pi2002
Prostaglandin E synthase0101
Polyunsaturated fatty acid lipoxygenase ALOX15B3003
Histone deacetylase 30101
Acetylcholinesterase0101
Lysine-specific histone demethylase 1A0101
D-amino-acid oxidase0101
Phospholipase A20101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10202
Amyloid-beta precursor protein0102
Neuronal proto-oncogene tyrosine-protein kinase Src 0101
Prostaglandin G/H synthase 10101
Cholinesterase0101
Heme oxygenase 1 0101
Glutathione S-transferase P0101
Polyunsaturated fatty acid 5-lipoxygenase0101
60 kDa chaperonin0101
Replicase polyprotein 1ab0213
Replicase polyprotein 1ab0213
Microtubule-associated protein tau0102
60 kDa heat shock protein, mitochondrial0202
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0101
Tissue factor0101
Tyrosinase0101
Aminopeptidase N0101
Aminopeptidase N0101
Gamma-aminobutyric acid receptor subunit beta-12002
Alpha-1B adrenergic receptor0202
Sarcoplasmic/endoplasmic reticulum calcium ATPase 20202
Glycogen synthase kinase-3 beta0101
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-22002
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
Amine oxidase [flavin-containing] A0202
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Acetylcholinesterase0101
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
Heme oxygenase 20101
Alpha-1D adrenergic receptor0202
Amine oxidase [flavin-containing] B0202
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Proteasome subunit beta type-50101
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit gamma-32002
Gamma-aminobutyric acid receptor subunit alpha-62002
Prostaglandin G/H synthase 20101
17-beta-hydroxysteroid dehydrogenase type 20101
Alpha-synuclein1214
Alpha-1A adrenergic receptor0202
Histamine H2 receptor3003
Glycogen synthase kinase-3 beta0101
Nuclear receptor ROR-gamma2002
Caspase-71001
Histone deacetylase 40101
Beta-secretase 10101
10 kDa heat shock protein, mitochondrial0202
Gamma-aminobutyric acid receptor subunit alpha-12002
Gamma-aminobutyric acid receptor subunit beta-32002
Guanine nucleotide-binding protein G1001
Gamma-aminobutyric acid receptor subunit beta-22002
Cholinesterase0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Lactoylglutathione lyase0101
Histone acetyltransferase p3000101
TAR DNA-binding protein 433003
Serine/threonine-protein kinase PAK 10101
Histone deacetylase 10202
5-hydroxytryptamine receptor 40011
Sodium/bile acid cotransporter0113
Nuclear factor erythroid 2-related factor 20011
Thiosulfate sulfurtransferase0202
Thioredoxin reductase 1, cytoplasmic0101
60 kDa chaperonin 0202
10 kDa chaperonin 0202
Thioredoxin reductase 30101
Sortase A0101
Histone deacetylase 70101
GABA theta subunit2002
Histone deacetylase 20202
CREB-binding protein0101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 30202
Cysteine protease 0101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
NACHT, LRR and PYD domains-containing protein 3 0101
Histone deacetylase 80202
Gamma-aminobutyric acid receptor subunit epsilon2002
Thioredoxin reductase 2, mitochondrial0101
CDGSH iron-sulfur domain-containing protein 10202
Histone deacetylase 60101
Histone deacetylase 90101
Broad substrate specificity ATP-binding cassette transporter ABCG20202
Histone deacetylase 50101
Lymphocyte antigen 960011
Beta lactamase (plasmid)0101
cytochrome P450 family 3 subfamily A polypeptide 43003
cytochrome P450 2D62002
Albumin0046
Reverse transcriptase/RNaseH 04412
Chain A, probable fosfomycin resistance protein0011
Chain B, probable fosfomycin resistance protein0011
DNA polymerase catalytic subunit0101
DNA polymerase catalytic subunit0101
DNA polymerase alpha catalytic subunit0101
DNA polymerase delta catalytic subunit0101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 90101
Chain A, Glutamine Binding Protein0011
arylsulfatase A2002
Bloom syndrome protein isoform 13003
peripheral myelin protein 22 isoform 11001
Neutral amino acid transporter A0101
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0101
Carbonic anhydrase-like protein, putative0001
Amino acid transporter0101
ATP-dependent phosphofructokinase4004
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain E, Fibrin beta chain0101
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, RNA-directed RNA polymerase NS50101
WRN1001
Mcl-10101
MPI protein0101
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)0001
PPM1D protein2002
hypothetical protein, conserved1001
regulator of G-protein signaling 41001
G2002
luciferase1001
pyruvate kinase1001
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
CDK50001
serine-protein kinase ATM isoform a1001
major prion protein preproprotein Prp precursor0101
glucose-6-phosphate 1-dehydrogenase isoform b0101
serine/threonine-protein kinase PLK12002
DNA polymerase eta isoform 11001
lethal(3)malignant brain tumor-like protein 1 isoform I1001
Tat0101
histone acetyltransferase KAT2A isoform 11001
endoribonuclease toxin MazF0011
Rap guanine nucleotide exchange factor 31001
HLA class I histocompatibility antigen, B alpha chain 2002
Pyruvate kinase PKM0101
Endothelin receptor type B1001
Endothelin-1 receptor1001
Inositol hexakisphosphate kinase 12002
cytochrome P450 2C9, partial2002
phosphoglycerate kinase1001
hypothetical protein CAALFM_CR05890CA0001
H3 histone acetyltransferase0001
large T antigen0101
Chain A, PROTEIN (PROTEASE)0101
Chain B, PROTEIN (PROTEASE)0101
Chain A, PROTEIN (PROTEASE)0101
Chain B, PROTEIN (PROTEASE)0101
Chain A, HIV-1 PROTEASE0101
Chain B, HIV-1 PROTEASE0101
Chain A, HIV-II PROTEASE0101
Chain B, HIV-II PROTEASE0101
Chain A, POL polyprotein0011
Chain B, POL polyprotein0011
Chain A, POL polyprotein0011
Chain B, POL polyprotein0011
Chain A, POL polyprotein0011
Chain B, POL polyprotein0011
Chain A, POL polyprotein0011
Chain B, POL polyprotein0011
Chain A, protease RETROPEPSIN0101
Chain B, protease RETROPEPSIN0101
Chain A, protease RETROPEPSIN0101
Chain B, protease RETROPEPSIN0101
Chain A, protease RETROPEPSIN0101
Chain B, protease RETROPEPSIN0101
Chain A, POL polyprotein0101
Chain B, POL polyprotein0101
Chain A, POL polyprotein0101
Chain B, POL polyprotein0101
Chain A, HIV-1 protease0101
Chain B, HIV-1 protease0101
Chain A, Pol polyprotein0101
Chain B, Pol polyprotein0101
Chain A, Pol polyprotein0101
Chain B, Pol polyprotein0101
Chain A, Pol polyprotein0101
Chain B, Pol polyprotein0101
Chain A, Pol polyprotein0101
Chain B, Pol polyprotein0101
Chain A, Hiv-1 Protease0101
Chain B, Hiv-1 Protease0101
Chain A, Hiv-1 Protease0101
Chain B, Hiv-1 Protease0101
Chain A, Hiv-1 Protease0101
Chain B, Hiv-1 Protease0101
Solute carrier family 22 member 20101
Solute carrier family 22 member 1 0101
Solute carrier family 22 member 30101
Gag-Pol polyprotein0202
Gag-Pol polyprotein0101
Gag-Pol polyprotein0101
Gag polyprotein0101
Gag-Pol polyprotein0101
ATP-dependent translocase ABCB10101
Cytochrome P450 3A40203
Cytochrome P450 2D60101
Gag-Pol polyprotein0202
Substance-K receptor0202
Thromboxane-A synthase 0101
Gag-Pol polyprotein0101
Thromboxane-A synthase0001
Genome polyprotein 0101
Solute carrier family 22 member 10101
Protease 0327
Multidrug and toxin extrusion protein 20101
Multidrug and toxin extrusion protein 10101
Protease 0213
Protease 0101
Thioredoxin reductase 0101
Flavodoxin0001
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Lanosterol 14-alpha demethylase0202
DNA-directed RNA polymerase subunit beta0101
Solute carrier organic anion transporter family member 1A40304
Bile salt export pump0203
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 2B1 0203
NH(3)-dependent NAD(+) synthetase0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Cytochrome P450 2B60011
Arylacetamide deacetylase0102
Caspase-10101
Solute carrier organic anion transporter family member 1A10203
Solute carrier organic anion transporter family member 1A20102
Glutathione S-transferase omega-10101
DNA gyrase subunit B0101
DNA gyrase subunit A0101
Enoyl-[acyl-carrier-protein] reductase [NADH]0101
DNA-directed RNA polymerase subunit beta0101
Solute carrier organic anion transporter family member 1B30204
Solute carrier organic anion transporter family member 1B10204
endonuclease IV1001
Thymidine kinase 2 0101
exodeoxyribonuclease V subunit RecD0101
exodeoxyribonuclease V subunit RecB0101
exodeoxyribonuclease V subunit RecC0101
muscarinic acetylcholine receptor M11001
Thymidine kinase, cytosolic0305
Thymidine kinase, cytosolic 0102
Sodium/bile acid cotransporter0001
Solute carrier family 22 member 60102
Solute carrier organic anion transporter family member 1A50001
ATP-binding cassette sub-family C member 30001
Sodium-dependent dopamine transporter0101
Sodium/bile acid cotransporter0102
Ileal sodium/bile acid cotransporter0001
Solute carrier organic anion transporter family member 1A30103
Ileal sodium/bile acid cotransporter0102
Ileal sodium/bile acid cotransporter0001
G-protein coupled bile acid receptor 10011
Solute carrier organic anion transporter family member0001
Solute carrier organic anion transporter family member 4A10001
Multidrug resistance associated protein0102
Solute carrier organic anion transporter family member 1C10101
Solute carrier organic anion transporter family member 2B10001
Solute carrier organic anion transporter family member 1A10001
Bile salt export pump0001
Solute carrier organic anion transporter family member 1B20001
Solute carrier family 22 member 80101
isocitrate dehydrogenase 1, partial1001
M-phase phosphoprotein 81001
Thermolysin0202
Neprilysin0202
Neprilysin0202
Neprilysin0101
EEF1AKMT4-ECE2 readthrough transcript protein0101
Angiotensin-converting enzyme 0101
Angiotensin-converting enzyme0101
Neprilysin0101
Type-1 angiotensin II receptor0101
Endothelin-converting enzyme 10202
Angiotensin-converting enzyme0101
Squalene synthase0101
Hsf1 protein0011
Aldo-keto reductase family 1 member B10001
Caspase-71001
caspase-31001
serine/threonine-protein kinase mTOR isoform 11001
tyrosine-protein kinase Yes1001
Ectonucleoside triphosphate diphosphohydrolase 10001
Protein kinase C beta type0101
DNA polymerase beta0101
UDP-glucuronosyltransferase 2B70001
Spike glycoprotein1001
Thymidylate kinase0101
Protein kinase C epsilon type0101
Thymidine kinase 0102
Solute carrier family 22 member 60001
Solute carrier family 22 member 70001
Solute carrier family 22 member 80001
Solute carrier family 22 member 110001
Thymidine kinase0102
Solute carrier family 22 member 70001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]