metronidazole has been researched along with Protein-Losing Enteropathies in 11 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Protein-Losing Enteropathies: Pathological conditions in the INTESTINES that are characterized by the gastrointestinal loss of serum proteins, including SERUM ALBUMIN; IMMUNOGLOBULINS; and at times LYMPHOCYTES. Severe condition can result in HYPOGAMMAGLOBULINEMIA or LYMPHOPENIA. Protein-losing enteropathies are associated with a number of diseases including INTESTINAL LYMPHANGIECTASIS; WHIPPLE'S DISEASE; and NEOPLASMS of the SMALL INTESTINE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Male Sprague-Dawley rats were dosed with two doses of metronidazole (50 mg/kg, 12 and 1 h pre-NSAID) or a single 100 mg/kg dose of tempo 1 h prior to NSAIDs." | 1.30 | Pharmacological protection of NSAID-induced intestinal permeability in the rat: effect of tempo and metronidazole as potential free radical scavengers. ( Davies, NM; Jamali, F, 1997) |
| "Serologic evidence of concomitant Mycoplasma pneumoniae infection was present." | 1.28 | Transient protein-losing hypertrophic gastropathy associated with Mycoplasma pneumoniae infection in childhood. ( Ben Amitai, D; Dinari, G; Garty, BZ; Zahavi, I, 1992) |
| "Pneumatosis cystoides intestinalis was a sequal in two patients." | 1.26 | Bypass enteropathy: an inflammatory process in the excluded segment with systemic complications. ( Ament, ME; Drenick, EJ; Finegold, SM; Passaro, E, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (45.45) | 18.7374 |
| 1990's | 4 (36.36) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Akkelle, BS | 1 |
| Tutar, E | 1 |
| Sengul, OK | 1 |
| Celikel, CA | 1 |
| Ertem, D | 1 |
| Ito, R | 1 |
| Sakagami, J | 1 |
| Kataoka, K | 1 |
| Nakamura, H | 1 |
| Motoyoshi, T | 1 |
| Takada, R | 1 |
| Kanemitsu, D | 1 |
| Yasuda, H | 1 |
| Mitsufuji, S | 1 |
| Okanoue, T | 1 |
| Sherman, P | 1 |
| Liebman, WM | 1 |
| Groisman, GM | 1 |
| George, J | 1 |
| Berman, D | 1 |
| Harpaz, N | 1 |
| Yamada, M | 1 |
| Sumazaki, R | 1 |
| Adachi, H | 1 |
| Ahmed, T | 1 |
| Matsubara, T | 1 |
| Hori, T | 1 |
| Nakahara, A | 1 |
| Takita, H | 1 |
| Davies, NM | 1 |
| Jamali, F | 1 |
| Drenick, EJ | 1 |
| Ament, ME | 2 |
| Finegold, SM | 1 |
| Passaro, E | 1 |
| Ochs, HD | 1 |
| Davis, SD | 1 |
| Ben Amitai, D | 1 |
| Zahavi, I | 1 |
| Dinari, G | 1 |
| Garty, BZ | 1 |
| Ehringhaus, C | 1 |
| Dominick, HC | 1 |
| Schüller, M | 1 |
| Sutton, DL | 1 |
| Kamath, KR | 1 |
11 other studies available for metronidazole and Protein-Losing Enteropathies
| Article | Year |
|---|---|
A Rare Complication of Giardiasis in Children: Protein-losing Enteropathy.
Topics: Antiprotozoal Agents; Female; Giardia; Giardiasis; Humans; Infant; Male; Metronidazole; Protein-Losi | 2018 |
Chronic diarrhea and protein-losing gastroenteropathy caused by Dientamoeba fragilis.
Topics: Aged; Antiprotozoal Agents; Biopsy; Chronic Disease; Colon; Diarrhea; Dientamoebiasis; Feces; Female | 2004 |
Apparent protein-losing enteropathy associated with giardiasis.
Topics: Child, Preschool; Giardia; Giardiasis; Humans; Intestinal Diseases, Parasitic; Male; Metronidazole; | 1980 |
Resolution of protein-losing hypertrophic lymphocytic gastritis with therapeutic eradication of Helicobacter pylori.
Topics: Amoxicillin; Bismuth; Drug Therapy, Combination; Female; Gastric Mucosa; Gastritis, Hypertrophic; He | 1994 |
Resolution of protein-losing hypertrophic gastropathy by eradication of Helicobacter pylori.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer Agents; Chil | 1997 |
Pharmacological protection of NSAID-induced intestinal permeability in the rat: effect of tempo and metronidazole as potential free radical scavengers.
Topics: Administration, Oral; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomar | 1997 |
Bypass enteropathy: an inflammatory process in the excluded segment with systemic complications.
Topics: Adult; Albumins; Arthritis; Body Weight; Dermatitis; Diarrhea; Female; Humans; Ileum; Inflammation; | 1977 |
Structure and function of the gastrointestinal tract in primary immunodeficiency syndromes (IDS) and in granulocyte dysfunction.
Topics: Carotenoids; Crohn Disease; Digestive System; Disaccharidases; Feces; Female; Folic Acid; Gastrointe | 1975 |
Transient protein-losing hypertrophic gastropathy associated with Mycoplasma pneumoniae infection in childhood.
Topics: Amoxicillin; Antacids; Antibodies, Bacterial; Child, Preschool; Enzyme-Linked Immunosorbent Assay; G | 1992 |
Protein-losing enteropathy associated with Clostridium perfringens infection.
Topics: Child, Preschool; Clostridium perfringens; Enterocolitis, Pseudomembranous; Female; Humans; Metronid | 1989 |
Giardiasis with protein-losing enteropathy.
Topics: Child, Preschool; Giardiasis; Humans; Male; Metronidazole; Protein-Losing Enteropathies | 1985 |