metronidazole has been researched along with Retinal Degeneration in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Retinal Degeneration: A retrogressive pathological change in the retina, focal or generalized, caused by genetic defects, inflammation, trauma, vascular disease, or aging. Degeneration affecting predominantly the macula lutea of the retina is MACULAR DEGENERATION. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p304)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hurdles in the treatment of retinal degeneration include managing the functional rewiring of surviving photoreceptors and integration of any newly added cells into the remaining second-order retinal neurons." | 1.43 | Rapid Recovery of Visual Function Associated with Blue Cone Ablation in Zebrafish. ( Allison, WT; Cao, SY; DuVal, MG; Hagerman, GF; Noel, NC; Oel, AP, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Langhe, R | 1 |
| Chesneau, A | 2 |
| Colozza, G | 1 |
| Hidalgo, M | 1 |
| Ail, D | 1 |
| Locker, M | 1 |
| Perron, M | 2 |
| Bronchain, O | 1 |
| Hagerman, GF | 1 |
| Noel, NC | 1 |
| Cao, SY | 1 |
| DuVal, MG | 1 |
| Oel, AP | 1 |
| Allison, WT | 1 |
3 other studies available for metronidazole and Retinal Degeneration
| Article | Year |
|---|---|
Müller glial cell reactivation in Xenopus models of retinal degeneration.
Topics: Age Factors; Animals; Animals, Genetically Modified; Animals, Newborn; Bromodeoxyuridine; Cell Proli | 2017 |
Conditional Chemogenetic Ablation of Photoreceptor Cells in Xenopus Retina.
Topics: Animals; Animals, Genetically Modified; Green Fluorescent Proteins; Metronidazole; Nitroreductases; | 2018 |
Rapid Recovery of Visual Function Associated with Blue Cone Ablation in Zebrafish.
Topics: Ablation Techniques; Animals; Animals, Genetically Modified; Cell Death; Cell Proliferation; Larva; | 2016 |