Infection with nematodes of the genus ONCHOCERCA. Characteristics include the presence of firm subcutaneous nodules filled with adult worms, PRURITUS, and ocular lesions.
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| "Thus, onchocerciasis is contributing more than was perhaps realized to the reduced output of work from farmers." | ( Nwoke, BE, 1992) |
| "Onchocerciasis is a major blinding disease that, until recently, has been essentially untreatable." | ( Greene, BM; Muñoz, B; Pacqué, M; Taylor, HR, 1990) |
| "We concluded that onchocerciasis is hypoendemic in Bure area with mild clinical manifestations." | ( Ayele, T; Mengistu, F; Yeneneh, H, 1989) |
| "Onchocerciasis is a major blinding disease affecting at least 28 million people in Africa and Latin America." | ( Taylor, HR, 1987) |
| "Onchocerciasis is a disease where often there are high levels of serum antibodies and high parasitic loads." | ( Braga, M; el Sheikh, H; Luty, AJ; Mackenzie, CD; O'Day, J; Sisley, BM; Steward, MW; Williams, JF, 1987) |
| "Onchocerciasis is found in association with all the main river systems of northern tropical Africa, and there are endemic foci south of the Equator." | ( Waddy, BB, 1969) |
| "Since onchocerciasis is not known by a specific name in the Thyolo highlands, information was sought about individual perceptions of common symptoms of infection." | ( Burnham, G; Courtright, P; Johnston, K, 1994) |
| "Onchocerciasis is associated with blindness and gross skin changes, believed to be a consequence of the immune response to antigens released from the offspring of the female worm of Onchocerca volvulus, the microfilariae (mf)." | ( Akuffo, H; Britton, S; Engström, K; Lavebratt, C; Maasho, K, 1996) |
| "Onchocerciasis is a major blinding disease in equatorial Africa and Central and South America." | ( Anselmi, M; Calvopiña, HM; Cooper, PJ; Espinel, M; Guderian, RH; Mancero, T; Proaño, R; Rivadeneira, G; Vieira, JC, 1997) |
| "Onchocerciasis is far more prevalent and far more of a public-health and socio-economic problem in Uganda than it was thought to be a decade ago." | ( Ndyomugyenyi, R, 1998) |
| "Onchocerciasis is a major public health problem in Uganda, affecting 17 of the country's 39 districts." | ( Okwero, P, 1998) |
| "Although onchocerciasis is also known as river blindness, it is not just a disease of the eyes, but rather a chronic multisystem disease." | ( Burov, E; Telang, GH; Turner, SE; Vernick, W, 2000) |
| "In Uganda, human onchocerciasis is controlled by annual, mass, community-directed, ivermectin-treatment programmes (CDITP) in all endemic communities where the prevalence of the disease is > or = 30%." | ( Katabarwa, NM; Mutabazi, D; Richards, FO, 2000) |
| "Although onchocerciasis is no longer a problem of public health importance nor an obstacle to socio-economic development in the OCP area, the control of this filariasis is not over because OCP never aimed at eradication, neither of the parasite (Onchocerca volvulus), nor of its vector (Simulium damnosum s." | ( Hougard, JM; Philippon, B; Yameogo, L, 2002) |
| "Onchocerciasis is an infestation caused by the nematode, Onchocerca volvulus, and characterized by eye manifestations, skin lesions and troublesome itching." | ( BenEzra, D; Enk, CD; Gardlo, K; Ruzicka, T, 2003) |
| "Onchocerciasis is co-endemic with schistosomiasis and intestinal helminths infections, which are all diseases of the rural and the poorest communities in Africa." | ( Kabatereine, N; Ndyomugyenyi, R, 2003) |
| "Onchocerciasis is a common, chronic multisystem disease with dermatologic, ocular, and systemic manifestations." | ( Elston, DM; Okulicz, JF; Schwartz, RA; Stibich, AS, 2004) |
| "Onchocerciasis is a filarial infection which causes blindness and debilitating skin lesions." | ( Boatin, BA; Richards, FO, 2006) |
| "Onchocerciasis is a filarial disease caused by Onchocerca volvuvus which can lead to skin, bladder or ocular signs." | ( Gaulier, A; Niamba, P; Taïeb, A, 2007) |
| "Onchocerciasis is a leading cause of blindness worldwide, hence elimination of the infection is an important health priority." | ( Cooper, PJ; Guderian, RH; Guzmán, JR; López, AA; Lovato, R; Mancero, T; Proaño, R; Rivera, J; Vieira, JC, 2007) |
| "Onchocerciasis is an endemic disease in Ondo state, Nigeria." | ( Adejai, ET; Adeoye, GO; Akinsanya, B; Atalabi, T; Braide, E; Ibidapo, CA; Okeke, P; Otubanjo, OA, 2008) |
| "Onchocerciasis is a leading cause of blindness with at least 37 million people infected and more than 120 million people at risk of contracting the disease; most (99%) of this population, threatened by infection, live in Africa." | ( Bocanegra-García, V; Correa-Basurto, J; Guo, X; Lizarazo-Ortega, C; Rodríguez-Pérez, MA; Segura-Cabrera, A, 2011) |
| "Onchocerciasis is one of the leading infectious causes of blindness affecting over 37 million people of which 99% are in Africa." | ( Assob, JC; Kamga, HL; Nde Fon, P; Njem, PK; Njunda, AL; Shey, DN, 2011) |
| "Onchocerciasis is caused by Onchocerca volvulus and transmitted by Simulium species (black flies)." | ( Borges, R; Convit, J; Domínguez-Vázquez, A; Frontado, H; Grillet, ME; Olivero, V; Schuler, H, 2013) |
| "Although onchocerciasis is endemic disease in the study area, large proportion of the community had conspicuous misconceptions in all issues about its causation, transmission and preventive methods." | ( Legesse, M; Medhin, G; Weldegebreal, F; Weldegebriel, Z, 2014) |
| "Onchocerciasis is an infectious disease caused by the filaria Onchocerca volvulus." | ( Barzilai, A; Baum, S; Enk, CD; Greenberger, S; Pavlotsky, F; Schwartz, E; Solomon, M, 2014) |
| "Human onchocerciasis is a neglected tropical parasitic disease caused by Onchocerca volvulus (O." | ( Dana, D; Debalke, S; Getahun, K; Kassahun, W; Mekonnen, Z; Suleman, S; Yewhalaw, D, 2015) |
| "Onchocerciasis is one of the most important public health problems over large areas of tropical Africa countries including Ethiopia." | ( Legesse, M; Medhin, G; Weldegebreal, F; Weldegebriel, Z, 2016) |
| "Although onchocerciasis is endemic in Quara district, large proportion of the CDDs had misconceptions about its causation, transmission and prevention." | ( Legesse, M; Medhin, G; Weldegebreal, F; Weldegebriel, Z, 2016) |
| "Onchocerciasis is a neglected parasitic disease affecting the poorest underserved people in Yemen." | ( Abdul-Ghani, R; Beier, JC; Mahdy, MAK, 2016) |
| "Onchocerciasis is a severe parasitic infection which causes disabling skin and subcutaneous tissue changes." | ( Deribe, K; Feleke, SM; Kebede, B; Mengistu, B; Meribo, K; Mulugeta, A; Samuel, A; Sileshi, M; Tadesse, Z, 2017) |
| "Onchocerciasis is endemic in 12 of the 14 health districts of Sierra Leone." | ( Bah, M; Bockarie, MJ; Conteh, A; Hodges, MH; Koroma, JB; Koudou, B; Paye, J; Sesay, S; Sonnie, M; Zhang, Y, 2018) |
| "Onchocerciasis is found predominantly in Africa where large scale vector control started in 1974." | ( Amazigo, UV; Boatin, BA; Dadzie, Y; Sékétéli, A, 2018) |
| "Onchocerciasis is a neglected tropical disease targeted for elimination." | ( Aziz, NA; Bekele, F; Dominguez-Vazquez, A; Fernández-Santos, NA; Habomugisha, P; Katabarwa, M; Lovato Silva, R; Mohammed, A; Morales Monroy, Z; Oguttu, DW; Richards, FO; Rizzo, N; Rodriguez-Perez, MA; Sauerbrey, M; Schuler Martínez, HR; Tadesse, Z; Unnasch, TR; Zarroug, IMA, 2018) |
| "Onchocerciasis is a severely debilitating yet neglected tropical disease (NTD) that creates social stigma, generates and perpetuates poverty, and leads ultimately in some cases to irreversible unilateral or bilateral blindness if untreated." | ( Gainkam, LOT; Ghogomu, SM; Humblet, P; Kamgno, J; Lelubre, C; Munyampundu, JP; Mutesa, L; Njume, FN; Poelvoorde, P; Robert, A; Shey, RA; Souopgui, J; Vanhamme, L, 2018) |
| "Onchocerciasis is an endemic disease in parts of sub-Saharan Africa." | ( Bouchat, RR; Ledder, G; Sylvester, D; Thiel, JA, 2018) |
| "Onchocerciasis is known to be associated with skin and eye disease and more recently, neurological features have been recognized as a major manifestation." | ( Hotterbeekx, A; Idro, R; Lakwo, T; Namale Ssonko, V; Oyet, W, 2019) |
| "Onchocerciasis is a neglected tropical disease which is still of immense major public health concern in several areas of Africa and the Americas." | ( Agbenyikey, L; Andoh, D; Ankrah, CB; Aseidu, P; Atta-Nyarko, RJ; Awuah, E; Conduah, B; Gyasi, SF; Nuhu, AR; Obeng-Ofori, D; Otabil, KB; Schallig, HDFH, 2019) |
| "Onchocerciasis is a leading cause of blindness in the world." | ( Al-Qubati, Y; Kapila, R; Schwartz, RA; Shah, R; Zieleniewski, Ł, 2020) |
| "Onchocerciasis is a priority neglected tropical disease targeted for elimination by 2025." | ( Abong, RA; Amuam, A; Dean, L; Ekanya, R; Enyong, P; Forrer, A; Fung, EG; Hamill, L; Kah, E; Khan, JAM; Murdoch, ME; Ndongmo, WPC; Ndzeshang, BL; Niessen, L; Nji, TM; Njouendou, AJ; Njoumemi, Z; Nkimbeng, DA; Nnamdi, DB; Obie, ED; Ozano, K; Piotrowski, H; Taylor, MJ; Teghen, S; Theobald, S; Thomson, R; Turner, JD; Wanji, S; Watson, V; Woode, ME, 2019) |
| "Onchocerciasis is a neglected tropical disease caused by a nematode parasite, Onchocerca volvulus, and transmitted by bites of Simulium blackflies which breed near fast-flowing rivers." | ( Murdoch, ME, 2021) |
| "onchocerciasis is one of the major infectious diseases caused by Onchocerca volvulus." | ( Gamago, GA; Pone, JW; Teukeng, FFD; Todjom, FG; Tsapi, EM, 2020) |
| "Onchocerciasis is targeted for elimination mainly with annual community-directed treatment with ivermectin (CDTI)." | ( Abong, RA; Ashu, EE; Beng, AA; Dean, L; Ekanya, R; Enyong, P; Eyong, ME; Forrer, A; Fung, EG; Hamill, L; Kah, E; Murdoch, MM; Ndongmo, WPC; Ndzeshang, BL; Nji, TM; Njouendou, AJ; Nkimbeng, DA; Nnamdi, DB; Obie, ED; Ozano, K; Piotrowski, H; Suireng, A; Taylor, MJ; Teghen, S; Theobald, S; Thomson, R; Turner, JD; Wanji, S, 2021) |
| "Prophylaxis of onchocerciasis is not a new concept." | ( Bulman, CA; Jawahar, S; Lustigman, S; Sakanari, J; Tricoche, N, 2021) |
| "Despite this, onchocerciasis is still prevalent in the region due to existing and emerging contextual challenges." | ( Dean, L; Dum-Buo, N; Fung, EG; Nji, TM; Ozano, K; Piotrowski, H; Theobald, S; Thomson, R; Wanji, S, 2021) |
| "Onchocerciasis is targeted for elimination of transmission by 2030 in at least 21 countries." | ( Agyemang, D; Akilah, J; Anyaike, C; Downs, P; Hamill, L; Hill, B; Igbe, M; Isiyaku, S; Jones, I; MacKenzie, C; Marfo, B; Nyior, A; Pavluck, A; Trotignon, G; William, A; Yumba, D, 2022) |
| "Onchocerciasis is being actively transmitted within the Meme River Basin." | ( Abong, RA; Amuam, A; Cho, JF; Ekanya, R; Enyong, P; Esum, ME; Hamill, L; Ndzeshang, BL; Njouendou, AJ; Nkimbeng, DA; Obie, ED; Taylor, MJ; Thorogood, S; Turner, JD; Wanji, S, 2022) |
| "Onchocerciasis is a neglected tropical filarial disease transmitted by the bites of blackflies, causing blindness and severe skin lesions." | ( Grant, WN; Hedtke, SM; McCulloch, K; Shrestha, H, 2022) |
| "Onchocerciasis is a disease caused by infection with Onchocerca volvulus, which is transmitted to humans via the bite of several species of black fly, and is responsible for permanent blindness or vision loss, as well as severe skin disease." | ( Cromwell, EA; Donkers, KM; Hay, SI; Hill, E; Johnson, KB; Pigott, DM; Schipp, MF; Schmidt, CA, 2022) |
| "Onchocerciasis is endemic in most local government areas (LGAs) in Enugu and Ogun states." | ( Ekpo, UF; Eneanya, OA; Fischer, PU; Nwankwo, EN; Nwaorgu, OC; Soneye, IY; Weil, GJ, 2022) |
| "Onchocerciasis is one of the eleven neglected tropical diseases (NTDs) recently targeted by the World Health Organization (WHO) for elimination." | ( Agyei, SK; Ankomah, SE; Atta, JA; Fusheini, A; Kokuro, C; Kumah, E; Mensah-Acheampong, F; Otchere, G; Owusu, P, 2023) |
| "Onchocerciasis is a parasitic disease transmitted by black flies." | ( Al-Akeel, RK; Alexiou, A; Batiha, GE; Chikezie, FM; Opara, KN; Osei-Atweneboana, MY; Papadakis, M; Ubulom, PME; Yaro, CA, 2023) |
| "Onchocerciasis is a disease of public health concern due to the devastating consequences of the disease which impacts negatively on the lives of the people." | ( Abah, SO; Ezenwosu, IL; Nwobi, EA; Ossai, EN; Otache, AE; Uzochukwu, BS, 2023) |
| "Onchocerciasis is an infectious disease of public health and socio-economic importance in most parts of Sub-Saharan Africa." | ( Ayong, L; Ghogomu, SM; Ngwese, RA; Njemini, R; Shey, RA; Shintouo, CM; Souopgui, J; Teh, RN; Vanhamme, L; Yaah, NE; Yengo, BN, 2023) |
| "Onchocerciasis is a neglected tropical disease with 217." | ( Atekem, K; Biholong, D; Dixon, R; Jones, I; Kamgno, J; Nditanchou, R; Senyonjo, L; Trotignon, G, 2023) |
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| "A study of community-based treatment of onchocerciasis with ivermectin was undertaken in a rain forest area of Liberia to investigate the possible occurrence of serious adverse effects." | ( Dukuly, Z; Greene, BM; Keyvan-Larijani, E; Munoz, B; Pacque, MC; Taylor, HR; Williams, PN, 1989) |
| "The use of ivermectin for mass treatment in human onchocerciasis is justified, because no other drug was available." | ( Bories, C; Gayral, P; Loiseau, P, 1989) |
| "Ivermectin is a new drug for treatment of onchocerciasis." | ( Otterlei, O, 1989) |
| "Four drug regimens for treating onchocerciasis were compared in a double-blind study in persons from an endemic area in southern Mexico." | ( Beltrán, F; Domíguez-Vázquez, A; Greene, BM; Lugo-Pfeiffer, C; Mackenzie, CD; Rivas-Alcalá, AR; Ruvalcaba-Macías, AM; Taylor, HR, 1981) |
| "The pathogenesis and treatment of onchocerciasis are discussed." | ( Koppert, HC, 1983) |
| "DEC has been employed in the treatment of onchocerciasis for many years, but there have been no reports of any effects of DEC on nodules." | ( Boye, ES; Connor, DH, 1982) |
| "During mass treatment of onchocerciasis with a single dose of 150 micrograms/kg of ivermectin, no difference of the efficacy was detected between persons with or without HIV and side effects in the two groups were similar." | ( Buttner, DW; Fischer, P; Kabwa, P; Kipp, W, 1995) |
| "Ivermectin is an effective drug for the treatment of human onchocerciasis, a disease caused by the parasitic filarial nematode Onchocerca volvulus." | ( Alley, ES; Boatin, BA; Bonneux, L; De Vlas, SJ; Habbema, JD; Plaisier, AP; Remme, H; Van Oortmarssen, GJ, 1995) |
| "Ivermectin treatment of onchocerciasis patients can be accompanied by adverse reactions." | ( Beek, WM; Keukens, HJ; Kijlstra, A; Njoo, FL; Oosting, J; Stilma, JS; van Wilgenburg, H, 1995) |
| "Ivermectin treatment of onchocerciasis can induce adverse reactions." | ( Hack, CE; Kijlstra, A; Luyendijk, L; Njoo, FL; Oosting, J; Stilma, JS, 1994) |
| "Adverse reactions following treatment of onchocerciasis and bancroftian filariasis are common and frequently severe." | ( Awadzi, K; Clark, IA; Francis, H; Ottesen, EA; Rockett, KA; Turner, PF, 1994) |
| "Since chemotherapy is widely used to treat onchocerciasis, the utility of PCR in assessing responses to treatment and in predicting recrudescence is important." | ( Guderian, RH; Kubofcik, J; Nutman, TB; Parredes, W, 1996) |
| "With regard to the treatment of onchocerciasis, studies have shown ivermectin to be well tolerated and effective in reducing microfilarial load, improving ocular and skin lesions, and reducing disease transmission." | ( Fagbenro-Beyiku, AF; Oyibo, WA, 1998) |
| "To find out whether biannual treatments of onchocerciasis with ivermectin were necessary or whether annual treatments could suffice, parasitologic and clinical results in Burundi were compared at 12 months after a single treatment and after two treatments with an interval of six months." | ( Newell, E; Vyungimana, F, 1998) |
| "Mass treatment of onchocerciasis has changed radically in the last 20 years." | ( Carlier, C; Chovet, M; Mariko, S; Queguiner, P, 1995) |
| "Worm nodules from untreated onchocerciasis patients displayed a strong neutrophil infiltrate adjacent to the live adult worms." | ( Brattig, NW; Büttner, DW; Hoerauf, A, 2001) |
| "During annual rounds of mass treatment against onchocerciasis, women who are pregnant or nursing neonates should not to be offered ivermectin." | ( Amazigo, U; Emukah, EC; Maduka, CU; Miri, ES; Nweke, LN; Richards, FO, 2004) |
| "In ivermectin-treated onchocerciasis patients, IL-5 production in responses to the mitogen phytohaemagglutinin (PHA) decreased, but IL-10 in response PHA increased, and neither attained the cytokine production levels of endemic controls." | ( Agossou, A; Banla, M; Hamm, DM; Heuschkel, C; Mai, CS; Schulz-Key, H; Soboslay, PT, 2007) |
| "Ivermectin has been used for mass treatment of onchocerciasis for up to 18 years, and recently there have been reports of poor parasitological responses to the drug." | ( Bourguinat, C; Boussinesq, M; Duke, BO; Gardon, J; Kamgno, J; Pion, SD; Prichard, RK, 2007) |
| "A major research effort for the safe treatment of onchocerciasis in loiasis-endemic areas has also been supported by the MDP." | ( Thylefors, B, 2008) |
| "The current treatment of onchocerciasis relies on the use of ivermectin which is only microfilaricidal and for which resistant parasite strains of veterinary importance are increasingly being detected." | ( Abongwa, M; Cho-Ngwa, F; Ngemenya, MN; Nyongbela, KD, 2010) |
| "Improved treatment for onchocerciasis is needed to accelerate onchocerciasis elimination in Africa." | ( Ayisi-Boateng, NK; Batsa Debrah, L; Debrah, AY; Dubben, B; Fimmers, R; Fischer, K; Gruetzmacher, B; Hoerauf, A; Kazura, JW; King, CL; Klarmann-Schulz, U; Konadu, P; Mubarik, Y; Nadal, J; Osei-Mensah, J; Ricchiuto, A; Weil, G, 2020) |
| "These results suggest that safe mass treatment of onchocerciasis may be possible at the subdepartment level, even in departments where loiasis is present." | ( Atsame, J; Biamonte, M; Diggle, PJ; Ella, SN; Gass, K; Hundley, L; Johnson, O; Ogoussan, K, 2021) |
| "Repeated annual ivermectin treatment of onchocerciasis patients durably inhibited their patent O." | ( Banla, M; Gantin, RG; Halatoko, WA; Johanns, SI; Karabou, P; Köhler, C; Komlan, K; Luty, AJ; Schulz-Key, H; Soboslay, PT; Wangala, B, 2022) |
| "No other short-course oral treatment for onchocerciasis has been demonstrated to have macrofilaricidal activity." | ( Doe, F; Dubben, B; Fetcho, N; Fischer, K; Fischer, PU; Gordor, S; Goss, CW; Gyasi, ME; Hoerauf, A; Hong, AR; Kanza, E; King, CL; Laryea, R; Lew, D; Opoku, NO; Seidu, MA; Weil, GJ, 2023) |