Ophthalmia Neonatorum

Acute conjunctival inflammation in the newborn, usually caused by maternal gonococcal infection. The causative agent is NEISSERIA GONORRHOEAE. The baby's eyes are contaminated during passage through the birth canal.

Synonym
Ophthalmia Neonatorum

Excerpt	Reference
"Since gonococcal ophthalmia neonatorum is a preventable cause of blindness, the increasing incidence of gonorrheal infection in Africa calls for an urgent reexamination of policies for the prevention of this infection among African women and their newborn children, the majority of whom are born without antenatal care or a trained birth attendant."	( Galega, FP; Heymann, DL; Nasah, BT, 1984)
"Ophthalmia neonatorum is defined as conjunctivitis appearing during the first month of life."	( Lehman, SS, 1999)
"Ophthalmia neonatorum is a form of conjunctivitis occurring in infants younger than 4 weeks."	( Abolgasemi, H; Amirsalari, S; Beiragdar, F; Kavemanesh, Z; Matinzadeh, ZK, 2007)
"Ophthalmia neonatorum is a form of bacterial conjunctivitis contracted by newborns during delivery and occurs during the first month of life."	( Ali, Z; Elahe, A; Fateme, Z; Khadije, D; Mohammad, M; Narges, Z, 2007)
"Ophthalmia neonatorum is an acute muco-purulent conjunctivitis occurring in the first month of birth."	( Catenazzi, P; D'Andrea, V; Romagnoli, C; Scorrano, A; Zuppa, AA, 2011)
"Ophthalmia neonatorum is one of the most common infections during the neonatal period."	( Kumar, JB; Silverstein, E; Wallace, DK, 2015)
"Ophthalmia neonatorum is an infection of the eyes in newborns that can lead to blindness, particularly if the infection is caused by Neisseria gonorrhoeae."	( Evans, JR; Kapoor, VS; Vedula, SS, 2020)

Excerpt	Reference
"Although prophylactic eyedrops to treat ophthalmia neonatorum is mandated nationwide, states and hospitals are free to choose specific drugs."	( Apt, L; Isenberg, SJ; Zanoni, D, 1992)
"RESULTS Preventive treatment for ophthalmia neonatorum was administrated to all newborns in 75% (24/32) of Croatian maternity hospitals."	( Anić Jurica, S; Bakija, I; Gverović Antunica, A; Herman, M; Kaštelan, S; Marković, I; Orešković, S; Župić, T, 2018)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	196 (71.27)	23.3326
1990's	36 (13.09)	12.5806
2000's	16 (5.82)	18.1394
2010's	23 (8.36)	28.8240
2020's	4 (1.45)	9.53

Drug	Relationship Strength	Studies	Trials
iodine	low	1	0
toluene	low	1	0
cefuroxime	low	1	0
ciprofloxacin	low	1	0
ddt	low	1	0
flucytosine	low	1	0
gentamicin	medium	9	2
isoniazid	low	1	0
methenamine	medium	1	1
metronidazole	low	1	0
norfloxacin	low	1	0
ofloxacin	low	2	0
probenecid	low	5	0
sulfacetamide	low	3	0
sulfamethoxazole	low	1	0
sulfanilamide	low	7	0
tetracaine	low	1	0
trimethoprim	low	1	0
cephaloridine	low	2	0
penicillin g	low	15	0
idoxuridine	low	1	0
chloramphenicol	medium	9	1
physostigmine	low	1	0
ethinyl estradiol	low	3	0
kanamycin a	medium	7	2
cycloheximide	low	1	0
ampicillin	low	9	0
methylprednisolone	low	1	0
penicillin v	low	1	0
n-vinyl-2-pyrrolidinone	low	1	0
framycetin	low	5	0
myristic acid	low	1	0
silver acetate	low	1	0
erythromycin	medium	54	5
spectinomycin	low	7	0
streptomycin	low	2	0
mercury	low	1	0
silver	low	6	0
silver nitrate	medium	146	10
trolamine salicylate	low	3	0
thiamphenicol	low	1	0
cromolyn sodium	low	1	0
iodine	medium	1	1
cephapirin	low	1	0
phenyl acetate	low	2	0
amoxicillin	low	1	0
tobramycin	low	3	0
desogestrel	low	3	0
ortho-cept	low	3	0
cephalosporin c	low	7	0
silver	low	1	0
clarithromycin	low	1	0
rac-glycerol 1-monodecanoate	low	2	0
povidone-iodine	medium	24	6
bekanamycin	low	1	0
netilmicin	low	1	0
zithromax	low	2	0
fusidic acid	low	1	0
vitamin k semiquinone radical	low	3	0
amphotericin b	low	1	0
nitrofurazone	low	1	0
cefotaxime	medium	7	1
rifamycins	low	1	0
gramicidin a	low	1	0
ro13-9904	medium	11	1
colistin	low	1	0
tetracycline	medium	36	4
chlortetracycline	low	3	0
oxytetracycline, anhydrous	low	6	0
eye	low	16	0

Protein Targets (663)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	14	0	0	14
Chain A, Beta-lactamase	6	0	0	6
Chain A, 2-oxoglutarate Oxygenase	11	0	0	11
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	4
AR protein	19	0	0	19
apical membrane antigen 1, AMA1	3	0	0	3
estrogen nuclear receptor alpha	28	0	0	28
Beta-lactamase	0	0	0	4
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	7	0	0	7
urokinase-type plasminogen activator precursor	7	0	0	7
plasminogen precursor	7	0	0	7
urokinase plasminogen activator surface receptor precursor	7	0	0	7
DNA polymerase kappa isoform 1	4	0	0	4
ATP-binding cassette sub-family C member 3	0	21	0	21
Multidrug resistance-associated protein 4	0	21	0	21
Bile salt export pump	0	7	0	7
Bile salt export pump	0	29	0	29
Beta-lactamase SHV-1	0	0	0	3
Beta-lactamase SHV-1	0	0	0	4
Cytochrome P450 2C9	0	6	0	6
Beta-lactamase	0	0	0	4
Kappa-type opioid receptor	0	2	0	5
Solute carrier family 15 member 1	0	8	0	8
Solute carrier family 15 member 1	0	2	0	2
Cytochrome P450 2J2	0	4	0	4
B2 metallo-beta-lactamase	0	0	0	4
Solute carrier family 15 member 2	0	5	0	5
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
Solute carrier family 15 member 2	0	6	0	6
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
Canalicular multispecific organic anion transporter 1	0	21	0	21
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
Chain A, Cruzipain	5	0	0	5
interleukin 8	10	0	0	10
phosphopantetheinyl transferase	4	0	0	4
GLS protein	5	0	0	5
glucocorticoid receptor [Homo sapiens]	15	0	0	15
farnesoid X nuclear receptor	10	0	0	10
peroxisome proliferator-activated receptor delta	7	0	0	7
vitamin D (1,25- dihydroxyvitamin D3) receptor	11	0	0	11
tumor necrosis factor	1	0	0	1
vitamin D3 receptor isoform VDRA	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 1	13	0	0	13
peripheral myelin protein 22	7	0	0	7
lamin isoform A-delta10	13	0	0	13
Cytochrome P450 1A2	0	3	0	3
Cytochrome P450 3A4	0	9	1	10
Cytochrome P450 2D6	0	3	0	3
Cytochrome P450 2C19	0	3	0	3
Nuclear receptor ROR-gamma	6	0	0	6
Potassium voltage-gated channel subfamily H member 2	0	8	0	9
Aurora kinase B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Beta-lactamase	0	0	0	3
acid sphingomyelinase	3	0	0	3
GLI family zinc finger 3	18	0	0	18
retinoic acid nuclear receptor alpha variant 1	16	0	0	16
Beta-lactamase	0	1	0	4
Beta-lactamase	0	0	0	3
Metallo-beta-lactamase type 2	0	0	0	3
Metallo-beta-lactamase VIM-11	0	0	0	3
euchromatic histone-lysine N-methyltransferase 2	11	0	0	11
Metallo-beta-lactamase VIM-2	0	0	0	3
Beta-lactamase	0	0	0	3
Metallo-beta-lactamase	0	0	0	3
Beta-lactamase	0	1	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	6	0	0	6
chromobox protein homolog 1	16	0	0	16
thyroid hormone receptor beta isoform 2	17	0	0	17
DNA polymerase beta	2	0	0	2
geminin	26	0	0	26
Carbonic anhydrase 1	0	5	0	6
Carbonic anhydrase 2	0	5	1	7
60 kDa heat shock protein, mitochondrial	0	2	0	2
Beta-lactamase OXA-7	0	0	0	2
Spike glycoprotein	2	0	1	3
10 kDa heat shock protein, mitochondrial	0	2	0	2
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Thiosulfate sulfurtransferase	0	2	0	2
Metallo-beta-lactamase VIM-13	0	0	0	3
Efflux transporter	0	0	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase Toho-1	0	0	0	4
Beta-lactamase	0	0	0	3
Class D beta-lactamase	0	0	0	2
60 kDa chaperonin	0	2	0	2
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
10 kDa chaperonin	0	2	0	2
Metallo-b-lactamase	0	0	0	4
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	4
Histamine H3 receptor	0	0	0	2
Beta-lactamase class B VIM-2	0	0	0	4
Beta-lactamase VIM-1	0	0	0	3
ATP-dependent phosphofructokinase	3	0	0	3
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	2	0	2
Acyl-protein thioesterase 1	0	2	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase VIM-19	0	0	0	2
Beta-lactamase	0	0	0	3
Solute carrier family 22 member 6	0	4	0	4
Albumin	0	0	4	4
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
Metallo-beta-lactamase VIM-2	0	0	0	2
Solute carrier family 22 member 6	0	5	0	5
Solute carrier family 22 member 7	0	3	0	3
BlaVIM-1	0	0	0	2
Beta-lactamase	0	0	0	3
Solute carrier family 22 member 8	0	5	0	6
Beta-lactamase	0	0	0	3
Solute carrier family 22 member 11	0	4	0	5
Solute carrier family 22 member 8	0	5	0	6
Solute carrier family 22 member 7	0	4	0	5
Beta-lactamase	0	0	0	2
aryl hydrocarbon receptor	10	0	0	10
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
Beta-lactamase	0	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Solute carrier family 22 member 5	0	1	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase OXA-10	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase TEM	0	1	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase IMP-1	0	0	0	2
Beta-lactamase	0	0	0	2
TDP1 protein	16	0	0	16
aldehyde dehydrogenase 1 family, member A1	13	0	0	13
EWS/FLI fusion protein	11	0	0	11
estrogen-related nuclear receptor alpha	18	0	0	18
pregnane X nuclear receptor	16	0	0	16
G	6	0	0	6
cytochrome P450 2D6	5	0	0	5
peroxisome proliferator activated receptor gamma	9	0	0	9
activating transcription factor 6	7	0	0	7
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
heat shock protein beta-1	7	0	0	7
streptokinase A precursor	0	0	8	8
lethal factor (plasmid)	6	0	0	6
Dihydroxyacetone phosphate acyltransferase	0	0	0	2
Interferon beta	8	0	0	8
HLA class I histocompatibility antigen, B alpha chain	6	0	0	6
30S ribosomal protein S6	0	6	1	7
30S ribosomal protein S7	0	6	1	7
50S ribosomal protein L15	0	6	1	7
Cellular tumor antigen p53	12	0	0	12
50S ribosomal protein L10	0	6	1	7
50S ribosomal protein L11	0	6	1	7
50S ribosomal protein L7/L12	0	6	1	7
50S ribosomal protein L19	0	6	1	7
50S ribosomal protein L1	0	6	1	7
50S ribosomal protein L20	0	6	1	7
50S ribosomal protein L27	0	6	1	7
50S ribosomal protein L28	0	6	1	7
50S ribosomal protein L29	0	6	1	7
50S ribosomal protein L31	0	6	1	7
50S ribosomal protein L31 type B	0	6	1	7
50S ribosomal protein L32	0	6	1	7
50S ribosomal protein L33	0	6	1	7
50S ribosomal protein L34	0	6	1	7
50S ribosomal protein L35	0	6	1	7
50S ribosomal protein L36	0	6	1	7
30S ribosomal protein S10	0	6	1	7
30S ribosomal protein S11	0	6	1	7
30S ribosomal protein S12	0	6	1	7
30S ribosomal protein S13	0	6	1	7
30S ribosomal protein S16	0	6	1	7
30S ribosomal protein S18	0	6	1	7
30S ribosomal protein S19	0	6	1	7
30S ribosomal protein S20	0	6	1	7
30S ribosomal protein S2	0	6	1	7
30S ribosomal protein S3	0	6	1	7
30S ribosomal protein S4	0	6	1	7
30S ribosomal protein S5	0	6	1	7
30S ribosomal protein S8	0	6	1	7
30S ribosomal protein S9	0	6	1	7
50S ribosomal protein L13	0	6	1	7
50S ribosomal protein L14	0	6	1	7
50S ribosomal protein L16	0	6	1	7
50S ribosomal protein L23	0	6	1	7
30S ribosomal protein S15	0	6	1	7
50S ribosomal protein L17	0	6	1	7
50S ribosomal protein L21	0	6	1	7
50S ribosomal protein L30	0	6	1	7
50S ribosomal protein L6	0	6	1	7
30S ribosomal protein S14	0	6	1	7
30S ribosomal protein S17	0	6	1	7
30S ribosomal protein S1	0	6	1	7
50S ribosomal protein L18	0	6	1	7
50S ribosomal protein L2	0	6	1	7
50S ribosomal protein L3	0	6	1	7
50S ribosomal protein L24	0	6	1	7
50S ribosomal protein L4	0	6	1	7
50S ribosomal protein L22	0	6	1	7
50S ribosomal protein L5	0	6	1	7
30S ribosomal protein S21	0	6	1	7
50S ribosomal protein L25	0	6	1	7
50S ribosomal protein L36 2	0	6	1	7
Inositol hexakisphosphate kinase 1	6	0	0	6
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cytochrome P450 2C9, partial	6	0	0	6
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
P2Y purinoceptor 12	0	2	0	2
Protein-arginine deiminase type-4	0	8	0	8
cytochrome P450 2C9 precursor	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	6	3	0	9
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	4	0	7
DNA gyrase subunit B	0	4	0	7
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	2	0	3
DNA topoisomerase 2-alpha	0	1	0	4
Gamma-aminobutyric acid receptor subunit beta-1	6	3	0	9
Gamma-aminobutyric acid receptor subunit delta	6	3	0	9
Gamma-aminobutyric acid receptor subunit gamma-2	6	3	0	9
Gamma-aminobutyric acid receptor subunit alpha-5	6	3	0	9
Gamma-aminobutyric acid receptor subunit alpha-3	6	3	0	9
DNA gyrase subunit A	0	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	6	3	0	9
Gamma-aminobutyric acid receptor subunit alpha-2	6	3	0	9
Gamma-aminobutyric acid receptor subunit alpha-4	6	3	0	9
Gamma-aminobutyric acid receptor subunit gamma-3	6	3	0	9
Gamma-aminobutyric acid receptor subunit alpha-6	6	3	0	9
Multidrug resistance protein MdtK	0	0	2	2
Histamine H2 receptor	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	6	3	0	9
Gamma-aminobutyric acid receptor subunit beta-3	6	3	0	9
Gamma-aminobutyric acid receptor subunit beta-2	6	3	0	9
DNA gyrase subunit B	0	3	0	4
DNA gyrase subunit A	0	3	0	4
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	4
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	2	0	2
GABA theta subunit	6	3	0	9
Gamma-aminobutyric acid receptor subunit epsilon	6	3	0	9
cytochrome P450 family 3 subfamily A polypeptide 4	9	0	0	9
importin subunit beta-1 isoform 1	4	0	0	4
mitogen-activated protein kinase 1	4	0	0	4
snurportin-1	4	0	0	4
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
ATP-dependent translocase ABCB1	0	4	0	4
Solute carrier organic anion transporter family member 1B3	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	1	0	1
retinoid X nuclear receptor alpha	15	0	0	15
Alkaline phosphatase, germ cell type	0	1	0	1
G protein-coupled receptor GPR35	0	0	1	1
G-protein coupled receptor 35	0	0	1	1
G-protein coupled receptor 35	0	0	1	1
glp-1 receptor, partial	3	0	0	3
pregnane X receptor	3	0	0	3
RAR-related orphan receptor gamma	11	0	0	11
ATAD5 protein, partial	2	0	0	2
Fumarate hydratase	2	0	0	2
USP1 protein, partial	9	0	0	9
PPM1D protein	4	0	0	4
Smad3	2	0	0	2
estrogen receptor 2 (ER beta)	7	0	0	7
nuclear receptor subfamily 1, group I, member 3	9	0	0	9
progesterone receptor	9	0	0	9
polyprotein	2	0	0	2
67.9K protein	5	0	0	5
P53	1	0	0	1
RPL19A	0	0	1	1
IDH1	5	0	0	5
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	7	0	0	7
v-jun sarcoma virus 17 oncogene homolog (avian)	6	0	0	6
Histone H2A.x	6	0	0	6
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
cellular tumor antigen p53 isoform a	3	0	0	3
thyroid hormone receptor beta isoform a	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
ras-related protein Rab-9A	2	0	0	2
heat shock protein HSP 90-alpha isoform 2	0	1	0	2
nuclear receptor ROR-gamma isoform 1	4	0	0	4
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
survival motor neuron protein isoform d	5	0	0	5
cytochrome P450 3A4 isoform 1	6	0	0	6
COUP transcription factor 2 isoform a	0	1	0	1
Transmembrane protease serine 2	0	0	1	1
Glucose transporter	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	7	0	0	7
Hexose transporter 1	0	1	0	1
Procathepsin L	0	0	1	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	1	1	2
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Glutamate receptor 2	7	0	0	7
Alpha-synuclein	1	1	0	2
Eukaryotic initiation factor 4A-I	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	0	2
Peptidyl-prolyl cis-trans isomerase FKBP3	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP4	0	1	0	1
TAR DNA-binding protein 43	7	0	0	7
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	1	0	1
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	3	0	0	3
Endothelial PAS domain-containing protein 1	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP14	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4	0	1	0	1
heat shock protein 90, putative	0	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
hypoxia-inducible factor 1 alpha subunit	5	0	0	5
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
thyroid stimulating hormone receptor	9	0	0	9
thyroid stimulating hormone receptor	5	0	0	5
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
Androgen receptor	0	5	0	5
Sex hormone-binding globulin	0	0	2	2
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
serine/threonine-protein kinase PLK1	4	0	0	4
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	5	0	0	5
ATP-dependent translocase ABCB1	0	3	0	3
60 kDa chaperonin	0	1	0	1
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	3
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
Multidrug and toxin extrusion protein 1	0	3	0	3
Luciferase	4	0	0	4
Microtubule-associated protein tau	3	0	0	3
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
Vpr	2	0	0	2
Solute carrier family 22 member 2	0	1	0	1
Cytochrome P450 2B1	0	1	0	1
Estrogen receptor	0	2	1	3
Glucocorticoid receptor	0	4	0	4
Glycine receptor subunit alpha-1	0	4	0	4
Aldo-keto reductase family 1 member B1	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-4	2	0	0	2
Adenosine receptor A3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	2	0	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Alpha-1B adrenergic receptor	0	4	0	4
Glycine receptor subunit beta	0	4	0	4
Cytochrome P450 2B6	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	2	0	3
Glycine receptor subunit alpha-2	0	4	0	4
Sodium-dependent noradrenaline transporter	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Glycine receptor subunit alpha-3	0	4	0	4
Adenosine receptor A2a	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Mu-type opioid receptor	0	4	1	6
Kappa-type opioid receptor	0	4	1	6
Alpha-1A adrenergic receptor	0	4	0	4
Sulfotransferase 1A1	0	2	1	4
Sodium-dependent dopamine transporter	0	2	0	2
Aldehyde oxidase	0	1	0	1
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Estrogen receptor beta	0	1	1	2
Skn7p	0	0	0	1
nonstructural protein 1	5	0	0	5
heat shock protein 90	0	0	1	1
calcineurin A1, putative	0	0	1	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Menin	0	0	1	1
Lecithin retinol acyltransferase	0	1	0	1
Lethal factor	0	1	0	1
Protein Rev	0	0	2	2
Aminoglycoside 3'-phosphotransferase	0	0	0	1
Tyrosyl-DNA phosphodiesterase 1	0	2	0	2
Chain A, Type Iii Chloramphenicol Acetyltransferase	0	1	0	1
thioredoxin glutathione reductase	4	0	0	4
Estrogen receptor	0	0	2	2
Guanine nucleotide-binding protein G	2	0	0	2
Estrogen receptor beta	0	0	2	2
Canalicular multispecific organic anion transporter 1	0	2	0	2
large T antigen	0	1	0	1
Thymidine kinase	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	1
Thymidine phosphorylase	0	0	0	1
Thymidine kinase	0	0	0	1
acetylcholinesterase	5	0	0	5
histone deacetylase 9 isoform 3	1	0	0	1
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 15	0	2	0	2
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
cytochrome P450 2D6 isoform 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	9	0	0	9
N-glycosylase/DNA lyase	0	1	0	1
Polyphenol oxidase 2	0	1	0	1
Myeloperoxidase	0	1	0	1
Formamidopyrimidine-DNA glycosylase	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Macrophage migration inhibitory factor	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
Pantothenate synthetase	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Endonuclease 8-like 1	0	1	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
Gap junction alpha-1 protein	0	1	0	1
Gap junction beta-2 protein	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
muscleblind-like protein 1 isoform 1	3	0	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Opioid receptor, delta 1b	0	1	0	1
Solute carrier family 22 member 1	0	2	0	2
Acetylcholinesterase	0	3	0	4
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Alpha-2A adrenergic receptor	0	0	1	1
Muscarinic acetylcholine receptor M2	0	2	0	2
Translocator protein	0	0	1	1
Histidine decarboxylase	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Sodium-dependent serotonin transporter	0	1	0	1
Delta-type opioid receptor	0	3	0	4
Delta-type opioid receptor	0	3	1	5
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	3	1	7
Kappa-type opioid receptor	0	2	1	4
UDP-glucuronosyltransferase 1A3	0	0	0	1
Delta-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	1	5
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	4	0	4
Beta-2 adrenergic receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	3	0	3
flap endonuclease 1	3	0	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Toll-like receptor 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Peroxisome proliferator-activated receptor delta	0	0	0	1
Dynamin-1	0	1	0	1
Peroxisome proliferator-activated receptor alpha	1	0	1	2
G-protein coupled receptor 84	0	1	1	2
thioredoxin reductase	5	0	0	5
transcriptional regulator ERG isoform 3	2	0	0	2
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
Metabotropic glutamate receptor 5	0	2	0	2
Snake venom metalloproteinase BaP1	0	1	0	1
NAD(+) hydrolase SARM1	0	2	0	2
huntingtin isoform 2	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Chain A, Ferritin light chain	3	0	0	3
arylsulfatase A	3	0	0	3
STE24	0	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
CAAX prenyl protease	0	0	0	1
Trypsin	0	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
WRN	1	0	0	1
Valosin-containing protein	0	1	0	1
regulator of G-protein signaling 4	2	0	0	2
microphthalmia-associated transcription factor isoform 9	0	1	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Serum paraoxonase/arylesterase 1	0	2	0	2
phosphoglycerate kinase	1	0	0	1
Solute carrier family 22 member 8	0	3	0	4
Beta-lactamase 1	0	0	0	1
Beta-lactamase	0	0	0	1
Bloom syndrome protein isoform 1	2	0	0	2
hexokinase-4 isoform 1	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
glucokinase regulatory protein	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
Acetylcholinesterase	0	1	0	1
Cholinesterase	0	3	0	3
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	3	0	4
Acetylcholinesterase	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Cholinesterase	0	2	0	3
Cholinesterase	0	1	0	1
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
alpha-galactosidase	1	0	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Carbonic anhydrase 12	0	2	0	2
UDP-glucuronosyltransferase 1A9	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Carbonic anhydrase 9	0	3	0	3
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Pannexin-1	0	1	0	1
Solute carrier family 22 member 12	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
Pannexin-1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 7	0	1	0	1
Dual specificity protein phosphatase 3	0	1	0	1
Dihydrofolate reductase	0	3	0	3
Dihydrofolate reductase	0	2	0	2
exodeoxyribonuclease V subunit RecD	0	2	0	2
exodeoxyribonuclease V subunit RecB	0	2	0	2
exodeoxyribonuclease V subunit RecC	0	2	0	2
ATP-dependent 6-phosphofructokinase	0	1	0	1
Dihydropteroate synthase	0	2	0	2
5-hydroxytryptamine receptor 2A	0	4	0	4
Dihydrofolate reductase	0	3	0	4
Endothelin-1 receptor	0	2	0	2
Protease	0	1	1	2
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2	0	1	1	2
Carbonic anhydrase 3	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
Carbonic anhydrase 6	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	2	0	3
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Protein argonaute-2	0	0	1	1
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
Transcriptional activator protein LasR	0	1	0	1
Endothelin-1 receptor	0	1	0	1
Protein arginine N-methyltransferase 6	0	1	0	1
muscarinic acetylcholine receptor M1	2	0	0	2
Potassium channel subfamily K member 3	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Amine oxidase [flavin-containing] A	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
cGMP-gated cation channel alpha-1	0	0	1	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Neutrophil collagenase	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
Endolysin	0	0	1	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
endonuclease IV	1	0	0	1
dopamine D1 receptor	1	0	0	1
NFKB1 protein, partial	1	0	0	1
cytochrome P450 2C19 precursor	1	0	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	1	0	1
twin arginine protein translocation system - TatA protein	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (275)

Protein Targets (663)

Ophthalmia Neonatorum

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (275)

Drugs Studied (77)

Protein Targets (663)