metronidazole has been researched along with Chlamydia Infections in 39 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Chlamydia Infections: Infections with bacteria of the genus CHLAMYDIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to evaluate the effect of metronidazole treatment on the incidence of postoperative pelvic inflammatory disease after first-trimester abortion in women with bacterial vaginosis." | 9.07 | Incidence of pelvic inflammatory disease after first-trimester legal abortion in women with bacterial vaginosis after treatment with metronidazole: a double-blind, randomized study. ( Forsum, U; Larsson, PG; Påhlson, C; Platz-Christensen, JJ; Thejls, H, 1992) |
| "55 women with signs and symptoms of non-specific vaginitis, NSV, were treated with metronidazole 1200 mg daily in a single dose for 5 days." | 9.05 | Treatment of non-specific vaginitis with metronidazole. ( Eng, J; Jerve, F; Qvigstad, E, 1983) |
| "Uncomplicated pelvic inflammatory disease (PID) is a common disease caused by numerous pathogens: sexually transmitted infections (such as Chlamydia trachomatis, Neisseria gonorrhoeae and Mycoplasma genitalium), anaerobes, and other organisms from the vaginal flora." | 6.74 | Levofloxacin plus metronidazole in uncomplicated pelvic inflammatory disease: a preliminary study. ( Judlin, P; Thiebaugeorges, O, 2009) |
| "Ciprofloxacin was less effective than combination treatment against Gardnerella vaginalis." | 5.28 | The effect of ciprofloxacin and doxycycline plus metronidazole on lower genital tract flora in patients with proven pelvic inflammatory disease. ( Heinonen, PK; Laine, S; Miettinen, A; Teisala, K, 1991) |
| "The purpose of this study was to evaluate the effect of metronidazole treatment on the incidence of postoperative pelvic inflammatory disease after first-trimester abortion in women with bacterial vaginosis." | 5.07 | Incidence of pelvic inflammatory disease after first-trimester legal abortion in women with bacterial vaginosis after treatment with metronidazole: a double-blind, randomized study. ( Forsum, U; Larsson, PG; Påhlson, C; Platz-Christensen, JJ; Thejls, H, 1992) |
| "55 women with signs and symptoms of non-specific vaginitis, NSV, were treated with metronidazole 1200 mg daily in a single dose for 5 days." | 5.05 | Treatment of non-specific vaginitis with metronidazole. ( Eng, J; Jerve, F; Qvigstad, E, 1983) |
| "One hundred forty-six consecutive inpatients with acute pelvic inflammatory disease (PID) were randomly treated either with the combination of doxycycline and metronidazole or with the combination of penicillin G/amoxicillin and metronidazole." | 5.05 | Factors predicting abnormal hysterosalpingographic findings in patients treated for acute pelvic inflammatory disease. ( Aantaa, K; Paavonen, J; Räsänen, J; Vesterinen, E, 1985) |
| "Although vaginitis is a common outpatient problem, only 60% of patients can be diagnosed at the initial office visit of a primary care provider using the office procedures of pH testing, whiff tests, normal saline, and potassium hydroxide preps." | 3.73 | "Shotgun" versus sequential testing. Cost-effectiveness of diagnostic strategies for vaginitis. ( Carr, PL; Felsenstein, D; Friedman, RH; Pliskin, JS; Rothberg, MB, 2005) |
| "Uncomplicated pelvic inflammatory disease (PID) is a common disease caused by numerous pathogens: sexually transmitted infections (such as Chlamydia trachomatis, Neisseria gonorrhoeae and Mycoplasma genitalium), anaerobes, and other organisms from the vaginal flora." | 2.74 | Levofloxacin plus metronidazole in uncomplicated pelvic inflammatory disease: a preliminary study. ( Judlin, P; Thiebaugeorges, O, 2009) |
| "Treatment of asymptomatic bacterial vaginosis or T." | 2.41 | Bacterial vaginosis and other asymptomatic vaginal infections in pregnancy. ( Carey, JC; Klebanoff, MA, 2001) |
| " The recommended treatment for gonorrhea is ceftriaxone monotherapy given intramuscularly, with dosing based on the patient's body weight." | 1.72 | Sexually Transmitted Infections: Updates From the 2021 CDC Guidelines. ( Dalby, J; Stoner, BP, 2022) |
| "Most patients (81%) with pelvic inflammatory disease were diagnosed as having chlamydia alone." | 1.48 | Gonococcal and Chlamydial Cases of Pelvic Inflammatory Disease at 2 Canadian Sexually Transmitted Infection Clinics, 2004 to 2014: A Retrospective Cross-sectional Review. ( Chen, JZ; Gratrix, J; Parker, P; Read, R; Singh, AE; Smyczek, P, 2018) |
| "Prompt and effective treatment of pelvic inflammatory disease (PID) may help prevent long-term complications." | 1.36 | Management of first-episode pelvic inflammatory disease in primary care: results from a large UK primary care database. ( Cassell, J; Hughes, G; Mercer, CH; Murray-Thomas, T; Nicholson, A; Rait, G, 2010) |
| "Metronidazole was administered orally in a dose of 250 mg twice a day for 10 days." | 1.30 | [Effect of metronidazole on luminol dependent chemiluminescence of neutrophils in whole blood of patients with chlamydial infection]. ( Iur'ev, SIu; Shchepetkin, IA, 1998) |
| "Ciprofloxacin was less effective than combination treatment against Gardnerella vaginalis." | 1.28 | The effect of ciprofloxacin and doxycycline plus metronidazole on lower genital tract flora in patients with proven pelvic inflammatory disease. ( Heinonen, PK; Laine, S; Miettinen, A; Teisala, K, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (23.08) | 18.7374 |
| 1990's | 8 (20.51) | 18.2507 |
| 2000's | 8 (20.51) | 29.6817 |
| 2010's | 11 (28.21) | 24.3611 |
| 2020's | 3 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Dalby, J | 1 |
| Stoner, BP | 1 |
| Gadoth, A | 1 |
| Shannon, CL | 1 |
| Hoff, NA | 1 |
| Mvumbi, G | 1 |
| Musene, K | 1 |
| Okitolonda-Wemakoy, E | 1 |
| Hoffman, RM | 1 |
| Rimoin, AW | 1 |
| Klausner, JD | 1 |
| Mitchell, C | 1 |
| Stemmer, SM | 1 |
| Mordechai, E | 1 |
| Adelson, ME | 1 |
| Gygax, SE | 1 |
| Hilbert, DW | 1 |
| Chen, JZ | 1 |
| Gratrix, J | 1 |
| Smyczek, P | 1 |
| Parker, P | 1 |
| Read, R | 1 |
| Singh, AE | 1 |
| Haumann, A | 1 |
| Ongaro, S | 1 |
| Detry, O | 1 |
| Meunier, P | 1 |
| Meurisse, M | 1 |
| Ugianskiene, A | 1 |
| McCormick, DF | 1 |
| Rahman, M | 1 |
| Zadrozny, S | 1 |
| Alam, A | 1 |
| Ashraf, L | 1 |
| Neilsen, GA | 1 |
| Kelly, R | 1 |
| Menezes, P | 1 |
| Miller, WC | 1 |
| Hoffman, IF | 1 |
| Horner, P | 1 |
| Blee, K | 1 |
| O'Mahony, C | 1 |
| Muir, P | 1 |
| Evans, C | 1 |
| Radcliffe, K | 1 |
| Llata, E | 1 |
| Bernstein, KT | 1 |
| Kerani, RP | 1 |
| Pathela, P | 1 |
| Schwebke, JR | 2 |
| Schumacher, C | 1 |
| Stenger, M | 1 |
| Weinstock, HS | 1 |
| Balkus, JE | 1 |
| Manhart, LE | 1 |
| Lee, J | 1 |
| Anzala, O | 1 |
| Kimani, J | 1 |
| Schwebke, J | 1 |
| Shafi, J | 1 |
| Rivers, C | 1 |
| Kabare, E | 1 |
| Scott McClelland, R | 1 |
| Judlin, P | 1 |
| Thiebaugeorges, O | 1 |
| Nicholson, A | 1 |
| Rait, G | 1 |
| Murray-Thomas, T | 1 |
| Hughes, G | 1 |
| Mercer, CH | 1 |
| Cassell, J | 1 |
| Bohbot, JM | 1 |
| Norman, WV | 1 |
| Carey, JC | 2 |
| Klebanoff, MA | 2 |
| Sheffield, JS | 1 |
| Andrews, WW | 1 |
| Macpherson, C | 1 |
| Ernest, JM | 1 |
| Wapner, RJ | 1 |
| Trout, W | 1 |
| Moawad, A | 1 |
| Miodovnik, M | 1 |
| Sibai, B | 1 |
| Varner, MW | 1 |
| Caritis, SN | 1 |
| Dombrowski, M | 1 |
| Langer, O | 1 |
| O'Sullivan, MJ | 1 |
| Carr, PL | 1 |
| Rothberg, MB | 1 |
| Friedman, RH | 1 |
| Felsenstein, D | 1 |
| Pliskin, JS | 1 |
| Rackstraw, S | 1 |
| Viswalingam, ND | 1 |
| Goh, BT | 1 |
| Gibbs, RS | 1 |
| Desmond, R | 1 |
| Sathia, L | 1 |
| Ellis, B | 1 |
| Phillip, S | 1 |
| Winston, A | 1 |
| Smith, A | 1 |
| Jerve, F | 1 |
| Qvigstad, E | 1 |
| Eng, J | 1 |
| Smith, LS | 1 |
| Lauver, D | 1 |
| Schneider, GT | 1 |
| Shchepetkin, IA | 1 |
| Iur'ev, SIu | 1 |
| Ogawa, Y | 1 |
| Hatano, T | 1 |
| Blackwell, AL | 1 |
| Emery, SJ | 1 |
| Thomas, PD | 1 |
| Wareham, K | 1 |
| McCormack, WM | 1 |
| Stern, MS | 1 |
| MacKenzie, RG | 1 |
| Watt, B | 1 |
| Collee, JG | 1 |
| Larsson, PG | 1 |
| Platz-Christensen, JJ | 1 |
| Thejls, H | 1 |
| Forsum, U | 1 |
| Påhlson, C | 1 |
| Rousseau, S | 1 |
| Morisset, ME | 1 |
| Knoefel, F | 1 |
| Gattereau, D | 1 |
| Morisset, R | 1 |
| Miettinen, A | 1 |
| Laine, S | 1 |
| Teisala, K | 1 |
| Heinonen, PK | 1 |
| Paavonen, J | 1 |
| Vesterinen, E | 1 |
| Aantaa, K | 1 |
| Räsänen, J | 1 |
| Skjeldestad, FE | 1 |
| Dalen, A | 1 |
| Hoyme, UB | 1 |
| Eschenbach, DA | 1 |
| Monif, GR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase IIa Study of the Colonization Efficiency, Safety and Acceptability of LACTIN-V Administered Vaginally to Women With Bacterial Vaginosis[NCT00635622] | Phase 2 | 40 participants (Anticipated) | Interventional | 2008-04-30 | Completed | ||
| A Phase I Study of the Safety of LACTIN-V Administered Vaginally to Healthy Women[NCT00537576] | Phase 1 | 12 participants (Actual) | Interventional | 2007-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Acceptability and overall satisfaction with the study product was measured using the response to the following question: I would use the product again with the following response options (strongly agree, agree, neutral, disagree, strongly disagree)~Acceptability is reported as the number of women in each group who strongly agreed or agreed with the statement that they would use the product again." (NCT00537576)
Timeframe: 35 days
| Intervention | participants (Number) |
|---|---|
| Low Dose Applicator | 3 |
| Medium Dose Applicator | 3 |
| High Dose Applicator | 2 |
| Placebo Control Substance Low Dose | 1 |
| Placebo Control Substance Medium Dose | 0 |
| Placebo Control Substance High Dose | 1 |
Safety was measured by comparing the number of women experiencing adverse events of grade 3 or higher during the study. (NCT00537576)
Timeframe: 35 days
| Intervention | participants (Number) |
|---|---|
| Low Dose Applicator | 0 |
| Medium Dose Applicator | 0 |
| High Dose Applicator | 0 |
| Placebo Control Substance Low Dose | 0 |
| Placebo Control Substance Medium Dose | 0 |
| Placebo Control Substance High Dose | 0 |
Tolerability was measured as proportion of women remaining in the study, and NOT prematurely exiting the trial due to an adverse event. (NCT00537576)
Timeframe: 35 days
| Intervention | participants (Number) |
|---|---|
| Low Dose Applicator | 3 |
| Medium Dose Applicator | 3 |
| High Dose Applicator | 3 |
| Placebo Control Substance Low Dose | 1 |
| Placebo Control Substance Medium Dose | 1 |
| Placebo Control Substance High Dose | 1 |
4 reviews available for metronidazole and Chlamydia Infections
| Article | Year |
|---|---|
Bacterial vaginosis and other asymptomatic vaginal infections in pregnancy.
Topics: Adult; Anti-Bacterial Agents; Chlamydia Infections; Comorbidity; Female; Gonorrhea; Humans; Incidenc | 2001 |
[Urethritis].
Topics: Anti-Bacterial Agents; Antitrichomonal Agents; Chlamydia Infections; Chlamydia trachomatis; Diagnosi | 1999 |
Management of sexually transmissible infections during pregnancy.
Topics: Anti-Bacterial Agents; Candidiasis; Chlamydia Infections; Coitus; Condylomata Acuminata; Corynebacte | 1975 |
Bacterial challenges and evolving antibacterial drug strategy.
Topics: 4-Quinolones; Aminoglycosides; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Infections; C | 1992 |
8 trials available for metronidazole and Chlamydia Infections
| Article | Year |
|---|---|
Prevention and control of sexually transmissible infections among hotel-based female sex workers in Dhaka, Bangladesh.
Topics: Adolescent; Anti-Bacterial Agents; Azithromycin; Bangladesh; Candidiasis, Vulvovaginal; Cefixime; Ch | 2013 |
Periodic Presumptive Treatment for Vaginal Infections May Reduce the Incidence of Sexually Transmitted Bacterial Infections.
Topics: Adult; Anti-Infective Agents; Chlamydia Infections; Chlamydia trachomatis; Drug Therapy, Combination | 2016 |
Levofloxacin plus metronidazole in uncomplicated pelvic inflammatory disease: a preliminary study.
Topics: Adult; Anti-Bacterial Agents; Chlamydia Infections; Female; Humans; Levofloxacin; Metronidazole; Ofl | 2009 |
Spontaneous resolution of asymptomatic Chlamydia trachomatis in pregnancy.
Topics: Adult; Anti-Infective Agents; Chlamydia Infections; Chlamydia trachomatis; Double-Blind Method; Fema | 2005 |
A randomized trial of metronidazole in asymptomatic bacterial vaginosis to prevent the acquisition of sexually transmitted diseases.
Topics: Administration, Intravaginal; Adult; Alabama; Anti-Infective Agents; Chlamydia Infections; Female; G | 2007 |
Treatment of non-specific vaginitis with metronidazole.
Topics: Adolescent; Adult; Candidiasis, Vulvovaginal; Chlamydia Infections; Clinical Trials as Topic; Drug R | 1983 |
Incidence of pelvic inflammatory disease after first-trimester legal abortion in women with bacterial vaginosis after treatment with metronidazole: a double-blind, randomized study.
Topics: Abortion, Induced; Chlamydia Infections; Chlamydia trachomatis; Female; Gonorrhea; Humans; Metronida | 1992 |
Incidence of pelvic inflammatory disease after first-trimester legal abortion in women with bacterial vaginosis after treatment with metronidazole: a double-blind, randomized study.
Topics: Abortion, Induced; Chlamydia Infections; Chlamydia trachomatis; Female; Gonorrhea; Humans; Metronida | 1992 |
Incidence of pelvic inflammatory disease after first-trimester legal abortion in women with bacterial vaginosis after treatment with metronidazole: a double-blind, randomized study.
Topics: Abortion, Induced; Chlamydia Infections; Chlamydia trachomatis; Female; Gonorrhea; Humans; Metronida | 1992 |
Incidence of pelvic inflammatory disease after first-trimester legal abortion in women with bacterial vaginosis after treatment with metronidazole: a double-blind, randomized study.
Topics: Abortion, Induced; Chlamydia Infections; Chlamydia trachomatis; Female; Gonorrhea; Humans; Metronida | 1992 |
Factors predicting abnormal hysterosalpingographic findings in patients treated for acute pelvic inflammatory disease.
Topics: Acute Disease; Adolescent; Adult; Amoxicillin; Chlamydia Infections; Clinical Trials as Topic; Doxyc | 1985 |
27 other studies available for metronidazole and Chlamydia Infections
| Article | Year |
|---|---|
Sexually Transmitted Infections: Updates From the 2021 CDC Guidelines.
Topics: Adolescent; Ceftriaxone; Centers for Disease Control and Prevention, U.S.; Chlamydia Infections; Dox | 2022 |
Prenatal chlamydial, gonococcal, and trichomonal screening in the Democratic Republic of Congo for case detection and management.
Topics: Adult; Anti-Bacterial Agents; Azithromycin; Chlamydia Infections; Chlamydia trachomatis; Cross-Secti | 2020 |
To Effectively Treat Pelvic Inflammatory Disease, Look Beyond Coverage for Gonorrhea and Chlamydia.
Topics: Ceftriaxone; Chlamydia Infections; Chlamydia trachomatis; Doxycycline; Female; Gonorrhea; Humans; Me | 2021 |
Trichomonas vaginalis is most frequently detected in women at the age of peri-/premenopause: an unusual pattern for a sexually transmitted pathogen.
Topics: Adolescent; Adult; Age Distribution; Aged; Anti-Infective Agents; Child; Chlamydia Infections; Chlam | 2018 |
Gonococcal and Chlamydial Cases of Pelvic Inflammatory Disease at 2 Canadian Sexually Transmitted Infection Clinics, 2004 to 2014: A Retrospective Cross-sectional Review.
Topics: Adolescent; Adult; Ambulatory Care Facilities; Anti-Bacterial Agents; Canada; Chlamydia Infections; | 2018 |
Acute pelvic inflammatory disease as a rare cause of acute small bowel obstruction.
Topics: Abdomen, Acute; Acute Disease; Adult; Anti-Bacterial Agents; Chlamydia Infections; Chlamydia trachom | 2019 |
[Chlamydial infection with marked ascites that simulated ovarian cancer].
Topics: Anti-Bacterial Agents; Ascites; Chlamydia Infections; Chlamydia trachomatis; Diagnosis, Differential | 2013 |
2015 UK National Guideline on the management of non-gonococcal urethritis.
Topics: Anti-Bacterial Agents; Azithromycin; Chlamydia Infections; Chlamydia trachomatis; Disease Management | 2016 |
Management of Pelvic Inflammatory Disease in Selected U.S. Sexually Transmitted Disease Clinics: Sexually Transmitted Disease Surveillance Network, January 2010-December 2011.
Topics: Adolescent; Adult; Azithromycin; Centers for Disease Control and Prevention, U.S.; Chlamydia Infecti | 2015 |
Management of first-episode pelvic inflammatory disease in primary care: results from a large UK primary care database.
Topics: Adolescent; Adult; Anti-Infective Agents; Chlamydia Infections; Chlamydia trachomatis; Databases, Fa | 2010 |
[Chlamydia trachomatis: The enemy of the Fallopian tube].
Topics: Adolescent; Adult; Ceftriaxone; Chlamydia Infections; Chlamydia trachomatis; Doxycycline; Fallopian | 2011 |
Metronidazole prophylaxis before surgical abortion: retrospective review of 51 330 cases.
Topics: Abortion, Induced; Anti-Infective Agents; Antibiotic Prophylaxis; Canada; Chlamydia Infections; Chla | 2012 |
"Shotgun" versus sequential testing. Cost-effectiveness of diagnostic strategies for vaginitis.
Topics: Adult; Anti-Infective Agents; Chlamydia Infections; Cost of Illness; Cost-Benefit Analysis; Costs an | 2005 |
Can chlamydial conjunctivitis result from direct ejaculation into the eye?
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Azithromycin; Cervix Uteri; Chlamydia Infection | 2006 |
Asymptomatic bacterial vaginosis: is it time to treat?
Topics: Anti-Infective Agents; Chlamydia Infections; Female; Gonorrhea; Humans; Metronidazole; Randomized Co | 2007 |
Pharyngeal gonorrhoea - is dual therapy the way forward?
Topics: Anti-Bacterial Agents; Azithromycin; Cefixime; Chlamydia Infections; Doxycycline; Drug Therapy, Comb | 2007 |
Assessment and management of vaginitis and cervicitis.
Topics: Anti-Bacterial Agents; Antifungal Agents; Candidiasis, Vulvovaginal; Chlamydia Infections; Chlamydia | 1984 |
Vaginal infections. How to identify and treat them.
Topics: Adolescent; Adult; Candidiasis; Child; Chlamydia Infections; Female; Haemophilus Infections; Herpes | 1983 |
[Effect of metronidazole on luminol dependent chemiluminescence of neutrophils in whole blood of patients with chlamydial infection].
Topics: Administration, Oral; Adult; Antitrichomonal Agents; Chlamydia Infections; Chlamydia trachomatis; Fe | 1998 |
Universal prophylaxis for Chlamydia trachomatis and anaerobic vaginosis in women attending for suction termination of pregnancy: an audit of short-term health gains.
Topics: Abortion, Induced; Anti-Bacterial Agents; Antibiotic Prophylaxis; Chlamydia Infections; Chlamydia tr | 1999 |
Drugs for sexually transmitted infections.
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Antitrichomonal Agents; Azithromycin; Chlamydia | 1999 |
Venereal disease in adolescents.
Topics: Adolescent; Chlamydia Infections; Cytomegalovirus; Erythromycin; Female; Gonorrhea; Herpesviridae In | 1975 |
The role of laparoscopy in acute pelvic infections.
Topics: Acute Disease; Adult; Ampicillin; Chlamydia Infections; Drug Therapy, Combination; Female; Gonorrhea | 1991 |
The effect of ciprofloxacin and doxycycline plus metronidazole on lower genital tract flora in patients with proven pelvic inflammatory disease.
Topics: Adult; Bacteriological Techniques; Chlamydia Infections; Chlamydia trachomatis; Ciprofloxacin; Doxyc | 1991 |
Chlamydia trachomatis: is it possible to reduce the number of infections after abortions?
Topics: Abortion, Induced; Adult; Cervix Uteri; Chlamydia Infections; Chlamydia trachomatis; Drug Therapy, C | 1988 |
[Bacterial vaginitis. Microbiology, diagnosis, therapy and complications].
Topics: Anti-Bacterial Agents; Chlamydia Infections; Female; Gardnerella vaginalis; Gonorrhea; Haemophilus I | 1985 |
Choice of antibiotics and length of therapy in the treatment of acute salpingitis.
Topics: Acute Disease; Anti-Bacterial Agents; Cefoxitin; Chlamydia Infections; Chlamydia trachomatis; Doxycy | 1985 |