metronidazole has been researched along with Chronic Kidney Diseases in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with CKD/ESRD have a higher risk of initial episode, recurrence, and development of severe CDI than those without CKD or ESRD." | 2.61 | Clostridioides difficile Infection in Chronic Kidney Disease/End-Stage Renal Disease. ( Ramesh, MS; Yee, J, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shin, J | 1 |
| Wi, YM | 1 |
| Lee, YJ | 1 |
| Ramesh, MS | 1 |
| Yee, J | 1 |
| Kim, SC | 1 |
| Seo, MY | 1 |
| Lee, JY | 1 |
| Kim, KT | 1 |
| Cho, E | 1 |
| Kim, MG | 1 |
| Jo, SK | 1 |
| Cho, WY | 1 |
| Kim, HK | 1 |
1 review available for metronidazole and Chronic Kidney Diseases
| Article | Year |
|---|---|
Clostridioides difficile Infection in Chronic Kidney Disease/End-Stage Renal Disease.
Topics: Anti-Bacterial Agents; Antibodies, Monoclonal; Antimicrobial Stewardship; Broadly Neutralizing Antib | 2019 |
2 other studies available for metronidazole and Chronic Kidney Diseases
| Article | Year |
|---|---|
Metronidazole therapy as initial treatment of
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Clostridium Infections; Female; Humans; Incidence; K | 2019 |
Advanced chronic kidney disease: a strong risk factor for Clostridium difficile infection.
Topics: Aged; Anti-Infective Agents; Chi-Square Distribution; Clostridioides difficile; Enterocolitis, Pseud | 2016 |