metronidazole has been researched along with Hypothyroidism in 5 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Hypothyroidism: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report a case of isolated levothyroxine malabsorption in the course of chronic intestinal giardiasis, leading to severe hypothyroidism." | 7.69 | Chronic intestinal giardiasis with isolated levothyroxine malabsorption as reason for severe hypothyroidism--implications for localization of thyroid hormone absorption in the gut. ( Rose, F; Schlaghecke, R; Seppel, T, 1996) |
| "We report a case of isolated levothyroxine malabsorption in the course of chronic intestinal giardiasis, leading to severe hypothyroidism." | 3.69 | Chronic intestinal giardiasis with isolated levothyroxine malabsorption as reason for severe hypothyroidism--implications for localization of thyroid hormone absorption in the gut. ( Rose, F; Schlaghecke, R; Seppel, T, 1996) |
| "Necrotizing stomatitis is more commonly encountered in malnourished children in developing countries, and may subsequently result in devastating facial defects and death." | 1.33 | Necrotizing stomatitis in the developed world. ( Buchanan, JA; Cedro, M; Hodgson, TA; Joseph, T; Mirdin, A; Porter, SR, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kılıç, M | 1 |
| Bugdaci, MS | 1 |
| Zuhur, SS | 1 |
| Sokmen, M | 1 |
| Toksoy, B | 1 |
| Bayraktar, B | 1 |
| Albayrak, B | 1 |
| Altuntas, Y | 1 |
| BAKKE, JL | 1 |
| LAWRENCE, N | 1 |
| CAMPBELL, G | 1 |
| Buchanan, JA | 1 |
| Cedro, M | 1 |
| Mirdin, A | 1 |
| Joseph, T | 1 |
| Porter, SR | 1 |
| Hodgson, TA | 1 |
| Seppel, T | 1 |
| Rose, F | 1 |
| Schlaghecke, R | 1 |
1 trial available for metronidazole and Hypothyroidism
| Article | Year |
|---|---|
The role of Helicobacter pylori in patients with hypothyroidism in whom could not be achieved normal thyrotropin levels despite treatment with high doses of thyroxine.
Topics: Adult; Amoxicillin; Clarithromycin; Drug Therapy, Combination; Female; Gastritis; Helicobacter Infec | 2011 |
4 other studies available for metronidazole and Hypothyroidism
| Article | Year |
|---|---|
Primary trimethylaminuria (fish odor syndrome) and hypothyroidism in an adolescent.
Topics: Adolescent; Humans; Hypothyroidism; Male; Metabolism, Inborn Errors; Methylamines; Metronidazole; Mu | 2017 |
THE EFFECT OF METRONIDAZOLE ON THE SYNTHESIS OF THYROID STIMULATING HORMONE IN THE HYPOTHYROID RAT.
Topics: Hypothyroidism; Metabolism; Metronidazole; Pharmacology; Pituitary Gland; Research; Thyrotropin | 1965 |
Necrotizing stomatitis in the developed world.
Topics: Aged; Analgesics; Debridement; Deglutition Disorders; Developed Countries; Dietary Supplements; Ging | 2006 |
Chronic intestinal giardiasis with isolated levothyroxine malabsorption as reason for severe hypothyroidism--implications for localization of thyroid hormone absorption in the gut.
Topics: Antiprotozoal Agents; Female; Giardiasis; Graves Disease; Humans; Hypothyroidism; Intestinal Absorpt | 1996 |