metronidazole has been researched along with Infection, Toxoplasma gondii in 5 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole treatment increased the brain spiramycin area under the concentration-time curve from 0 h to ∞ (AUC(0-∞)) by 67% without affecting its plasma disposition." | 5.38 | Significant reduction of brain cysts caused by Toxoplasma gondii after treatment with spiramycin coadministered with metronidazole in a mouse model of chronic toxoplasmosis. ( Ambu, S; Chew, WK; Mak, JW; Segarra, I, 2012) |
| "Metronidazole treatment increased the brain spiramycin area under the concentration-time curve from 0 h to ∞ (AUC(0-∞)) by 67% without affecting its plasma disposition." | 1.38 | Significant reduction of brain cysts caused by Toxoplasma gondii after treatment with spiramycin coadministered with metronidazole in a mouse model of chronic toxoplasmosis. ( Ambu, S; Chew, WK; Mak, JW; Segarra, I, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chew, WK | 1 |
| Segarra, I | 1 |
| Ambu, S | 1 |
| Mak, JW | 1 |
| Trussell, RR | 1 |
| Beeley, L | 1 |
| Takada, S | 1 |
| Ellis, CJ | 1 |
| Müller, E | 1 |
| Sturm, G | 1 |
1 review available for metronidazole and Infection, Toxoplasma gondii
| Article | Year |
|---|---|
Prescribing in pregnancy. Infestations.
Topics: Animals; Anthelmintics; Antiprotozoal Agents; Bephenium Compounds; Cestode Infections; Female; Fetus | 1981 |
4 other studies available for metronidazole and Infection, Toxoplasma gondii
| Article | Year |
|---|---|
Significant reduction of brain cysts caused by Toxoplasma gondii after treatment with spiramycin coadministered with metronidazole in a mouse model of chronic toxoplasmosis.
Topics: Animals; Antiprotozoal Agents; Area Under Curve; Brain; Chromatography, High Pressure Liquid; Cysts; | 2012 |
[Drugs used against protozoan infections in man].
Topics: Amebiasis; Aminoquinolines; Antiprotozoal Agents; Humans; Malaria; Metronidazole; Pneumonia, Pneumoc | 1990 |
Antiparasitic agents in pregnancy.
Topics: Amebiasis; Female; Helminthiasis; Humans; Malaria; Metronidazole; Parasitic Diseases; Pregnancy; Pre | 1986 |
[Protozoan infections of the skin].
Topics: Amphotericin B; Antimony; Female; Germany, West; Humans; Leishmania; Leishmaniasis, Mucocutaneous; M | 1974 |