metronidazole has been researched along with Dermatitis, Irritant in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Dermatitis, Irritant: A non-allergic contact dermatitis caused by prolonged exposure to irritants and not explained by delayed hypersensitivity mechanisms.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ortiz, PG | 1 |
| Hansen, SH | 1 |
| Shah, VP | 1 |
| Menné, T | 1 |
| Benfeldt, E | 1 |
| Shelanski, MV | 1 |
| Phillips, SB | 1 |
| Potts, CE | 1 |
1 trial available for metronidazole and Dermatitis, Irritant
| Article | Year |
|---|---|
Evaluation of cutaneous reactivity to recently marketed dermatologic products.
Topics: Adult; Aged; Aged, 80 and over; Allergens; Antifungal Agents; Calcitriol; Clobetasol; Dermatitis, Ir | 1996 |
1 other study available for metronidazole and Dermatitis, Irritant
| Article | Year |
|---|---|
The effect of irritant dermatitis on cutaneous bioavailability of a metronidazole formulation, investigated by microdialysis and dermatopharmacokinetic method.
Topics: Administration, Cutaneous; Adult; Analysis of Variance; Area Under Curve; Biological Availability; D | 2008 |