metronidazole has been researched along with Liver Cirrhosis in 23 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The pharmacokinetics of metronidazole 500 mg orally were determined in patients with hepatosplenic schistosomiasis and normal controls in the Sudan, and in cirrhotics and normal controls in Bristol." | 7.66 | Disposition of oral metronidazole in hepatic cirrhosis and in hepatosplenic schistosomiasis. ( Daneshmend, TK; Elamin, AA; Homeida, M; Kaye, CM; Roberts, CJ, 1982) |
| "Encephalopathy is a disorder characterized by altered brain function, which can be attributed to various causes." | 5.37 | Metronidazole-induced encephalopathy in a patient with liver cirrhosis. ( Cheong, HC; Cho, EY; Cho, YB; Jeong, TG; Kim, HC; Kim, TH; Yang, BJ, 2011) |
| "Metronidazole pharmacokinetics were studied in patients with different degrees of liver cirrhosis, classified according to the Child-Pugh algorithm (A, B or C, as liver disease severity increases) and in schistosomic patients." | 5.08 | Plasma hydroxy-metronidazole/metronidazole ratio in patients with liver disease and in healthy volunteers. ( De Nucci, G; Ferraz, JG; Hofstätter, E; Leite, G; Leonardi, S; Magalhães, AF; Miranda, EL; Muscará, MN; Pedrazzoli, J, 1995) |
| "A 34-year-old Hispanic man with cirrhosis and hepatitis C being treated with metronidazole for Bacteroides fragilis meningitis and bacteremia developed ataxia, disorientation, and peripheral neuropathy." | 3.70 | Toxic metronidazole-induced MRI changes. ( Horlen, CK; Malouf, CS; Seifert, CF, 2000) |
| "The pharmacokinetics of metronidazole 500 mg orally were determined in patients with hepatosplenic schistosomiasis and normal controls in the Sudan, and in cirrhotics and normal controls in Bristol." | 3.66 | Disposition of oral metronidazole in hepatic cirrhosis and in hepatosplenic schistosomiasis. ( Daneshmend, TK; Elamin, AA; Homeida, M; Kaye, CM; Roberts, CJ, 1982) |
| "In cirrhotic patients with advanced hepatic encephalopathy treatment with LOLA was safe and associated with relatively rapid improvement and shorter hospital stay." | 2.76 | Efficacy of L-ornithine-L-aspartate as an adjuvant therapy in cirrhotic patients with hepatic encephalopathy. ( Abbas, Z; Abid, S; Hamid, S; Islam, M; Jafri, W; Mumtaz, K; Shah, HA, 2011) |
| "To review the management of hepatic encephalopathy (HE), including lifestyle modifying strategies and pharmacological interventions." | 2.53 | Management of Hepatic Encephalopathy: A Primer. ( Bridgeman, MB; Dixit, D; Jawaro, T; Yang, A, 2016) |
| "Hepatic encephalopathy is characterized by neuropsychiatric abnormalities in patients with liver failure." | 2.45 | Hepatic encephalopathy: pathophysiology and emerging therapies. ( Shaikh, OS; Sundaram, V, 2009) |
| "Encephalopathy is a disorder characterized by altered brain function, which can be attributed to various causes." | 1.37 | Metronidazole-induced encephalopathy in a patient with liver cirrhosis. ( Cheong, HC; Cho, EY; Cho, YB; Jeong, TG; Kim, HC; Kim, TH; Yang, BJ, 2011) |
| "Though amoebic liver abscess and liver cirrhosis occur very commonly in hospital practice in the tropics, they have not to the knowledge of the present authors hitherto been reported to occur simultaneously in the same patient." | 1.26 | Amoebic abscess in the cirrhotic liver. ( Falaiye, JM; Fregene, AO; Okeke, GC, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (21.74) | 18.7374 |
| 1990's | 2 (8.70) | 18.2507 |
| 2000's | 6 (26.09) | 29.6817 |
| 2010's | 9 (39.13) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Phatharacharukul, P | 1 |
| Purpura, RD | 1 |
| Gandhi, D | 1 |
| Xu, H | 1 |
| Bickett-Burkhart, K | 1 |
| Chalasani, N | 1 |
| Fischer, M | 1 |
| Orman, ES | 1 |
| Mekky, MA | 1 |
| Riad, AR | 1 |
| Gaber, MA | 1 |
| Abdel-Malek, MO | 1 |
| Swifee, YM | 1 |
| Motzkus-Feagans, C | 1 |
| Pakyz, AL | 1 |
| Ratliff, SM | 1 |
| Bajaj, JS | 1 |
| Lapane, KL | 1 |
| Trifan, A | 1 |
| Stoica, O | 1 |
| Stanciu, C | 1 |
| Cojocariu, C | 1 |
| Singeap, AM | 1 |
| Girleanu, I | 1 |
| Miftode, E | 1 |
| Farmakiotis, D | 1 |
| Zeluff, B | 1 |
| Aebischer, B | 1 |
| Elsig, S | 1 |
| Taeymans, J | 1 |
| Pomp, S | 1 |
| Kuhness, D | 1 |
| Barcaro, G | 1 |
| Sementa, L | 1 |
| Mankad, V | 1 |
| Fortunelli, A | 1 |
| Sterrer, M | 1 |
| Netzer, FP | 1 |
| Surnev, S | 1 |
| Schmieder, AH | 1 |
| Caruthers, SD | 1 |
| Keupp, J | 1 |
| Wickline, SA | 1 |
| Lanza, GM | 1 |
| Lowe, J | 1 |
| Wodarcyk, AJ | 1 |
| Floyd, KT | 1 |
| Rastogi, N | 1 |
| Schultz, EJ | 1 |
| Swager, SA | 1 |
| Chadwick, JA | 1 |
| Tran, T | 1 |
| Raman, SV | 1 |
| Janssen, PM | 1 |
| Rafael-Fortney, JA | 1 |
| Alcalay, RN | 1 |
| Levy, OA | 1 |
| Wolf, P | 1 |
| Oliva, P | 1 |
| Zhang, XK | 1 |
| Waters, CH | 1 |
| Fahn, S | 1 |
| Kang, U | 1 |
| Liong, C | 1 |
| Ford, B | 1 |
| Mazzoni, P | 1 |
| Kuo, S | 1 |
| Johnson, A | 1 |
| Xiong, L | 1 |
| Rouleau, GA | 1 |
| Chung, W | 1 |
| Marder, KS | 1 |
| Gan-Or, Z | 1 |
| Kamei, K | 1 |
| Terao, T | 1 |
| Katayama, Y | 1 |
| Hatano, K | 1 |
| Kodama, K | 1 |
| Shirahama, M | 1 |
| Sakai, A | 1 |
| Hirakawa, H | 1 |
| Mizokami, Y | 1 |
| Shiotsuki, I | 1 |
| Ishii, N | 1 |
| Inoue, Y | 1 |
| Akboga, MK | 1 |
| Yayla, C | 1 |
| Balci, KG | 1 |
| Ozeke, O | 1 |
| Maden, O | 1 |
| Kisacik, H | 1 |
| Temizhan, A | 1 |
| Aydogdu, S | 1 |
| Zhu, J | 2 |
| Ying, SH | 1 |
| Feng, MG | 1 |
| Zhang, XG | 1 |
| Li, H | 1 |
| Wang, L | 1 |
| Hao, YY | 1 |
| Liang, GD | 1 |
| Ma, YH | 1 |
| Yang, GS | 1 |
| Hu, JH | 1 |
| Pfeifer, L | 1 |
| Goertz, RS | 1 |
| Neurath, MF | 1 |
| Strobel, D | 1 |
| Wildner, D | 1 |
| Lin, JT | 1 |
| Yang, XN | 1 |
| Zhong, WZ | 1 |
| Liao, RQ | 1 |
| Dong, S | 1 |
| Nie, Q | 1 |
| Weng, SX | 1 |
| Fang, XJ | 1 |
| Zheng, JY | 1 |
| Wu, YL | 1 |
| Řezanka, T | 1 |
| Kaineder, K | 1 |
| Mezricky, D | 1 |
| Řezanka, M | 1 |
| Bišová, K | 1 |
| Zachleder, V | 1 |
| Vítová, M | 1 |
| Rinker, JA | 1 |
| Marshall, SA | 1 |
| Mazzone, CM | 1 |
| Lowery-Gionta, EG | 1 |
| Gulati, V | 1 |
| Pleil, KE | 1 |
| Kash, TL | 1 |
| Navarro, M | 1 |
| Thiele, TE | 1 |
| Zhang, Y | 1 |
| Huang, Y | 1 |
| Jin, Z | 1 |
| Li, X | 1 |
| Li, B | 1 |
| Xu, P | 1 |
| Huang, P | 1 |
| Liu, C | 1 |
| Fokdal, L | 1 |
| Sturdza, A | 1 |
| Mazeron, R | 1 |
| Haie-Meder, C | 1 |
| Tan, LT | 1 |
| Gillham, C | 1 |
| Šegedin, B | 1 |
| Jürgenliemk-Schultz, I | 1 |
| Kirisits, C | 1 |
| Hoskin, P | 1 |
| Pötter, R | 1 |
| Lindegaard, JC | 1 |
| Tanderup, K | 1 |
| Levin, DE | 1 |
| Schmitz, AJ | 1 |
| Hines, SM | 1 |
| Hines, KJ | 1 |
| Tucker, MJ | 1 |
| Brewer, SH | 1 |
| Fenlon, EE | 1 |
| Álvarez-Pérez, S | 1 |
| Blanco, JL | 1 |
| Peláez, T | 1 |
| Martínez-Nevado, E | 1 |
| García, ME | 1 |
| Puckerin, AA | 1 |
| Chang, DD | 1 |
| Subramanyam, P | 1 |
| Colecraft, HM | 1 |
| Dogan, H | 1 |
| Coteli, E | 1 |
| Karatas, F | 1 |
| Ceylan, O | 1 |
| Sahin, MD | 1 |
| Akdamar, G | 1 |
| Kryczyk, A | 1 |
| Żmudzki, P | 1 |
| Hubicka, U | 1 |
| Giovannelli, D | 1 |
| Chung, M | 1 |
| Staley, J | 1 |
| Starovoytov, V | 1 |
| Le Bris, N | 1 |
| Vetriani, C | 1 |
| Chen, W | 1 |
| Wu, L | 1 |
| Liu, X | 1 |
| Shen, Y | 1 |
| Liang, Y | 1 |
| Tan, H | 1 |
| Yang, Y | 1 |
| Liu, Q | 1 |
| Wang, M | 1 |
| Liu, L | 1 |
| Wang, X | 1 |
| Liu, B | 1 |
| Liu, GH | 1 |
| Zhu, YJ | 1 |
| Wang, JP | 1 |
| Che, JM | 1 |
| Chen, QQ | 1 |
| Chen, Z | 1 |
| Maucksch, U | 1 |
| Runge, R | 1 |
| Wunderlich, G | 1 |
| Freudenberg, R | 1 |
| Naumann, A | 1 |
| Kotzerke, J | 1 |
| Jawaro, T | 1 |
| Yang, A | 1 |
| Dixit, D | 1 |
| Bridgeman, MB | 1 |
| Sundaram, V | 1 |
| Shaikh, OS | 1 |
| Cheong, HC | 1 |
| Jeong, TG | 1 |
| Cho, YB | 1 |
| Yang, BJ | 1 |
| Kim, TH | 1 |
| Kim, HC | 1 |
| Cho, EY | 1 |
| Abid, S | 1 |
| Jafri, W | 1 |
| Mumtaz, K | 1 |
| Islam, M | 1 |
| Abbas, Z | 1 |
| Shah, HA | 1 |
| Hamid, S | 1 |
| Fehérvári, I | 1 |
| Nemes, B | 1 |
| Görög, D | 1 |
| Gerlei, Z | 1 |
| Kóbori, L | 1 |
| Marchioretto, MA | 1 |
| Ecclissato, C | 1 |
| da Silva, CM | 1 |
| Cassiano, NM | 1 |
| Calafatti, SA | 1 |
| Mendonça, S | 1 |
| Ribeiro, ML | 1 |
| Bernasconi, GC | 1 |
| Degger, MF | 1 |
| Piovesan, H | 1 |
| Pedrazzoli, J | 2 |
| Leung, WK | 1 |
| Chow, VC | 1 |
| Chan, MC | 1 |
| Ling, JM | 1 |
| Sung, JJ | 1 |
| Daneshmend, TK | 1 |
| Homeida, M | 1 |
| Kaye, CM | 1 |
| Elamin, AA | 1 |
| Roberts, CJ | 1 |
| Falaiye, JM | 1 |
| Okeke, GC | 1 |
| Fregene, AO | 1 |
| Muscará, MN | 1 |
| Miranda, EL | 1 |
| Ferraz, JG | 1 |
| Hofstätter, E | 1 |
| Leite, G | 1 |
| Magalhães, AF | 1 |
| Leonardi, S | 1 |
| De Nucci, G | 1 |
| Schölmerich, J | 1 |
| Glück, T | 1 |
| Azuma, T | 1 |
| Ito, S | 1 |
| Suto, H | 1 |
| Ito, Y | 1 |
| Miyaji, H | 1 |
| Yamazaki, Y | 1 |
| Kato, T | 1 |
| Kuriyama, M | 1 |
| Horlen, CK | 1 |
| Seifert, CF | 1 |
| Malouf, CS | 1 |
| Melhus, A | 1 |
| Archampong, EQ | 1 |
| Kampf, D | 1 |
| Borner, K | 1 |
| Huber, S | 1 |
| Gitlin, N | 1 |
6 reviews available for metronidazole and Liver Cirrhosis
| Article | Year |
|---|---|
Clostridium difficile infection in patients with liver disease: a review.
Topics: Anti-Bacterial Agents; Clostridioides difficile; Clostridium Infections; Diagnostic Tests, Routine; | 2015 |
Topics: AC133 Antigen; Acenaphthenes; Acer; Acrosome Reaction; Adult; Agaricales; Aged; Aged, 80 and over; A | 2016 |
Management of Hepatic Encephalopathy: A Primer.
Topics: Anti-Bacterial Agents; Disaccharides; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Metronidazole | 2016 |
Hepatic encephalopathy: pathophysiology and emerging therapies.
Topics: Ammonia; Anti-Infective Agents; Drug Therapy, Combination; Dyskinesias; Gastrointestinal Agents; Hep | 2009 |
[Hepatic encephalopathy and liver transplantation].
Topics: Ammonia; Anti-Infective Agents; Colon; Dipeptides; Disaccharides; End Stage Liver Disease; Evidence- | 2012 |
[Spontaneous bacterial peritonitis].
Topics: Animals; Ascites; Bacterial Infections; Bacterial Translocation; Cefotaxime; Diagnosis, Differential | 1998 |
4 trials available for metronidazole and Liver Cirrhosis
| Article | Year |
|---|---|
Rifaximin versus metronidazole in management of acute episode of hepatic encephalopathy: An open labeled randomized clinical trial.
Topics: Acute Disease; Adult; Ammonia; Anti-Infective Agents; Female; Hepatic Encephalopathy; Humans; Length | 2018 |
Efficacy of L-ornithine-L-aspartate as an adjuvant therapy in cirrhotic patients with hepatic encephalopathy.
Topics: Anti-Infective Agents; Dipeptides; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up | 2011 |
Plasma hydroxy-metronidazole/metronidazole ratio in patients with liver disease and in healthy volunteers.
Topics: Adult; Biotransformation; Female; Half-Life; Humans; Liver Cirrhosis; Liver Function Tests; Male; Me | 1995 |
Pharmacokinetics of clarithromycin in Helicobacter pylori eradication therapy in patients with liver cirrhosis.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Anti-Bacterial Agents; Anti-Ulcer Agents; Clarithromy | 2000 |
13 other studies available for metronidazole and Liver Cirrhosis
| Article | Year |
|---|---|
Incidence and Risk Factors of Recurrent Clostridioides difficile Infection in Patients With Cirrhosis.
Topics: Aged; Anti-Bacterial Agents; Clostridioides; Clostridium Infections; Comorbidity; Diagnostic Errors; | 2020 |
Statin use and infections in Veterans with cirrhosis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Clostridioides difficile; Enterocolitis, Pseu | 2013 |
IMAGES IN CLINICAL MEDICINE. Metronidazole-Associated Encephalopathy.
Topics: Bacteremia; Brain Diseases; Catheterization, Central Venous; Clostridium Infections; Dysarthria; Fat | 2016 |
Metronidazole-induced encephalopathy in a patient with liver cirrhosis.
Topics: Anti-Infective Agents; Brain Diseases; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Magnetic Res | 2011 |
Plasma hydroxy-metronidazole/metronidazole ratio in hepatitis C virus-induced liver disease.
Topics: Adult; Anti-Infective Agents; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid | 2005 |
Psychrobacter bacteraemia in a cirrhotic patient after the consumption of raw geoduck clam.
Topics: Ampicillin; Animals; Anti-Infective Agents; Bacteremia; Bivalvia; Ceftazidime; Food Microbiology; Fo | 2006 |
Disposition of oral metronidazole in hepatic cirrhosis and in hepatosplenic schistosomiasis.
Topics: Administration, Oral; Adult; Aged; Female; Humans; Kinetics; Liver Cirrhosis; Liver Diseases, Parasi | 1982 |
Amoebic abscess in the cirrhotic liver.
Topics: Humans; Liver Abscess, Amebic; Liver Cirrhosis; Male; Metronidazole; Middle Aged; Radiography | 1980 |
Toxic metronidazole-induced MRI changes.
Topics: Adult; Anti-Infective Agents; Brain; Hepatitis C; Humans; Liver Cirrhosis; Magnetic Resonance Imagin | 2000 |
First documented case of Aeromonas veronii biovar sobria infection in northern Europe.
Topics: Aeromonas; Aged; Anti-Bacterial Agents; Appendiceal Neoplasms; Cefuroxime; Gram-Negative Bacterial I | 2002 |
Amoebic liver disease.
Topics: Adolescent; Adult; Carcinoma, Hepatocellular; Child; Diagnosis, Differential; Female; Hepatomegaly; | 1977 |
Metronidazole kinetics and liver function in hepatic cirrhosis.
Topics: Adult; Biotransformation; Glomerular Filtration Rate; Humans; Liver Cirrhosis; Liver Function Tests; | 1987 |
The investigation and natural history of acute viral hepatitis.
Topics: Alanine Transaminase; Amebiasis; Antigens, Viral; Antistreptolysin; Aspartate Aminotransferases; Aut | 1973 |