metronidazole has been researched along with Pancreatic Diseases in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Pancreatic Diseases: Pathological processes of the PANCREAS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The penetrance of mezlocillin, metronidazole and trimethoprim-sulfamethoxazole into the pancreatic juice of humans was measured in ten patients convalescing from acute pancreatitis at the time of endoscopic retrograde cholangiopancreatography." | 3.67 | Assessment of antimicrobial penetrance into the pancreatic juice in humans. ( Bawdon, RE; Cushing, RD; Ledgerwood, AM; Lucas, CE; Sugawa, C; Wallace, JR, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mandrawa, CL | 1 |
| Cronin, K | 1 |
| Buising, KL | 1 |
| Poy Lorenzo, YS | 1 |
| Waters, MJ | 1 |
| Jeremiah, CJ | 1 |
| Miyahara, T | 1 |
| Kubokawa, M | 1 |
| Koyanagi, S | 1 |
| Migita, Y | 1 |
| Oogoshi, K | 1 |
| Sakai, H | 1 |
| Ito, T | 1 |
| Nakano, I | 1 |
| Nawata, H | 1 |
| Wallace, JR | 1 |
| Cushing, RD | 1 |
| Bawdon, RE | 1 |
| Sugawa, C | 1 |
| Lucas, CE | 1 |
| Ledgerwood, AM | 1 |
3 other studies available for metronidazole and Pancreatic Diseases
| Article | Year |
|---|---|
Carbapenemase-producing Klebsiella pneumoniae: a major clinical challenge.
Topics: Azabicyclo Compounds; Bacterial Proteins; beta-Lactamases; Carbapenems; Ceftazidime; Drug Resistance | 2016 |
A case of successfully treated giardiasis in pancreas.
Topics: Aged; Animals; Antiprotozoal Agents; Diabetes Mellitus, Type 2; Female; Giardiasis; Humans; Metronid | 1997 |
Assessment of antimicrobial penetrance into the pancreatic juice in humans.
Topics: Acute Disease; Cholangiopancreatography, Endoscopic Retrograde; Chromatography, High Pressure Liquid | 1986 |