metronidazole has been researched along with Wounds and Injuries in 15 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Wounds and Injuries: Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Malignant wounds are a devastating complication of cancer." | 2.55 | Systemic antibiotics for treating malignant wounds. ( Cronin, P; Hayden, F; Ramasubbu, DA; Smith, V, 2017) |
| "Fungating wounds arise from primary, secondary or recurrent malignant disease and are associated with advanced cancer." | 2.50 | Topical agents and dressings for fungating wounds. ( Adderley, UJ; Holt, IG, 2014) |
| "Metronidazole is a synthetic nitroimidazole derivative with antimicrobial and antiinflammatory properties." | 2.46 | Innovative use of topical metronidazole. ( Zip, CM, 2010) |
| "Fungating wounds arise from primary, secondary or recurrent malignant disease and are associated with advanced cancer." | 2.44 | Topical agents and dressings for fungating wounds. ( Adderley, U; Smith, R, 2007) |
| "Fingating wounds always present a management challenge." | 2.43 | Assessment and management of fungating wounds: a review. ( Wilson, V, 2005) |
| "Malodorous wounds are not only debilitating to patients physically, they can also cause them major social problems." | 2.42 | Recognising and treating the causes of chronic malodorous wounds. ( Holloway, S, 2004) |
| "Since many of the wounds from which tetanus arises are minor, patients may not bring them to medical attention." | 2.38 | Tetanus. A threat to elderly patients. ( Kellerman, RD; Lichtenhan, JB; Richards, JF, 1992) |
| "Malodor associated with each of 13 wounds was decreased following the initial treatment with topical metronidazole." | 1.29 | Case study: eliminating odors from wounds. ( Poteete, V, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Rotem, R | 1 |
| Mastrolia, SA | 1 |
| Rottenstreich, M | 1 |
| Yohay, D | 1 |
| Weintraub, AY | 1 |
| Ramasubbu, DA | 1 |
| Smith, V | 1 |
| Hayden, F | 1 |
| Cronin, P | 1 |
| Adderley, UJ | 1 |
| Holt, IG | 1 |
| Castro, DL | 1 |
| Santos, VL | 1 |
| Alexander, S | 1 |
| Zip, CM | 1 |
| Patel, B | 1 |
| Cox-Hayley, D | 1 |
| Holloway, S | 1 |
| Wilson, V | 1 |
| Mekrut-Barrows, C | 1 |
| Adderley, U | 1 |
| Smith, R | 1 |
| Poteete, V | 1 |
| Byl, B | 1 |
| Jacobs, F | 1 |
| Struelens, MJ | 1 |
| Thys, JP | 1 |
| Lichtenhan, JB | 1 |
| Kellerman, RD | 1 |
| Richards, JF | 1 |
| McMullen, D | 1 |
10 reviews available for metronidazole and Wounds and Injuries
| Article | Year |
|---|---|
The use of metronidazole in women undergoing obstetric anal sphincter injuries: a systematic review of the literature.
Topics: Adult; Anal Canal; Anti-Bacterial Agents; Antibiotic Prophylaxis; Delivery, Obstetric; Female; Human | 2020 |
Systemic antibiotics for treating malignant wounds.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Double-Blind Method; Humans; Metronidazole; Neoplasms; | 2017 |
Topical agents and dressings for fungating wounds.
Topics: Anti-Infective Agents, Local; Antineoplastic Agents; Biological Dressings; Disease Progression; Fema | 2014 |
[Controlling wound odor with metronidazole: a systematic review].
Topics: Deodorants; Humans; Metronidazole; Odorants; Wounds and Injuries | 2015 |
Innovative use of topical metronidazole.
Topics: Acute Generalized Exanthematous Pustulosis; Administration, Cutaneous; Adult; Anti-Infective Agents; | 2010 |
Managing wound odor #218.
Topics: Anti-Infective Agents; Bandages; Charcoal; Cultured Milk Products; Honey; Humans; Iodophors; Metroni | 2010 |
Recognising and treating the causes of chronic malodorous wounds.
Topics: Administration, Topical; Anti-Infective Agents; Bandages; Chronic Disease; Debridement; Gels; Humans | 2004 |
Assessment and management of fungating wounds: a review.
Topics: Administration, Topical; Alginates; Anti-Infective Agents; Bandages; Charcoal; Community Health Nurs | 2005 |
Topical agents and dressings for fungating wounds.
Topics: Anti-Infective Agents, Local; Antineoplastic Agents; Biological Dressings; Disease Progression; Fema | 2007 |
Tetanus. A threat to elderly patients.
Topics: Age Factors; Aged; Child; Clinical Protocols; Diagnosis, Differential; Female; Geriatrics; Humans; I | 1992 |
5 other studies available for metronidazole and Wounds and Injuries
| Article | Year |
|---|---|
Malignant fungating wounds: managing malodour and exudate.
Topics: Anti-Infective Agents; Anti-Infective Agents, Local; Bandages; Charcoal; Debridement; Exudates and T | 2009 |
Softening the pain of cancer-related wounds.
Topics: Aged; Female; Humans; Metronidazole; Neoplasms; Pain; Pain Management; Wounds and Injuries | 2006 |
Case study: eliminating odors from wounds.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Clinical Nursing Research; Gels; Humans; Me | 1993 |
Extraintestinal Clostridium difficile infections.
Topics: Adolescent; Aged; Anti-Bacterial Agents; Antitrichomonal Agents; Bacteremia; Ceftazidime; Cephalospo | 1996 |
Topical metronidazole. Part II.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Metronidazole; Middle | 1992 |