metronidazole has been researched along with Liver Cirrhosis, Biliary in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Liver Cirrhosis, Biliary: FIBROSIS of the hepatic parenchyma due to obstruction of BILE flow (CHOLESTASIS) in the intrahepatic or extrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC; BILE DUCTS, EXTRAHEPATIC). Primary biliary cholangitis involves the destruction of small intra-hepatic bile ducts and decreased bile secretion. Secondary biliary cholangitis is produced by prolonged obstruction of large intrahepatic or extrahepatic bile ducts from a variety of causes.
| Excerpt | Relevance | Reference |
|---|---|---|
| " difficile may contributed to the recurrent CDB episodes and liver abscess formation in necrotic liver tissue following TACE, and long-term metronidazole therapy was considered to be effective to C." | 3.85 | Recurrent bacteremia and liver abscess caused by Clostridium difficile: A case report. ( Iguchi, M; Kuzuya, T; Mikamo, H; Morioka, H; Yagi, T, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Morioka, H | 1 |
| Iguchi, M | 1 |
| Kuzuya, T | 1 |
| Mikamo, H | 1 |
| Yagi, T | 1 |
| Ma, HD | 1 |
| Zhao, ZB | 1 |
| Ma, WT | 1 |
| Liu, QZ | 1 |
| Gao, CY | 1 |
| Li, L | 1 |
| Wang, J | 1 |
| Tsuneyama, K | 1 |
| Liu, B | 1 |
| Zhang, W | 1 |
| Zhou, Y | 1 |
| Gershwin, ME | 1 |
| Lian, ZX | 1 |
2 other studies available for metronidazole and Liver Cirrhosis, Biliary
| Article | Year |
|---|---|
Recurrent bacteremia and liver abscess caused by Clostridium difficile: A case report.
Topics: Aged; Anti-Bacterial Agents; Bacteremia; Bacterial Translocation; Carcinoma, Hepatocellular; Chemoem | 2017 |
Gut microbiota translocation promotes autoimmune cholangitis.
Topics: Ampicillin; Animals; Anti-Bacterial Agents; Autoimmune Diseases; Bacterial Translocation; Bile Ducts | 2018 |