metronidazole has been researched along with Leishmaniasis, American in 7 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oral treatment with metronidazole led to rapid resolution with minimal scarring." | 1.32 | [First cases of imported cutaneous leishmaniasis in Bangui Central African Republic: efficacy of metronidazole]. ( Huerre, M; Kassa-Kelembho, E; Kobangue, L; Morvan, JM, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Somaratne, VN | 1 |
| Ranawaka, RR | 1 |
| Jayaruwan, HM | 1 |
| Wipuladasa, DM | 1 |
| de Silva, SHP | 1 |
| Chaabane, A | 1 |
| Romdhane, HB | 1 |
| Brahim, HB | 1 |
| Fredj, NB | 1 |
| Chadli, Z | 1 |
| Boughattas, NA | 1 |
| Chakroun, M | 1 |
| Aouam, K | 1 |
| Belhadjali, H | 1 |
| Elhani, I | 1 |
| Youssef, M | 1 |
| Babba, H | 1 |
| Zili, J | 1 |
| Kassa-Kelembho, E | 1 |
| Kobangue, L | 1 |
| Huerre, M | 1 |
| Morvan, JM | 1 |
| Al-Waiz, M | 1 |
| Sharquie, KE | 1 |
| Al-Assir, M | 1 |
| Masmoudi, A | 2 |
| Boudaya, S | 1 |
| Ayadi, N | 2 |
| Bouassida, S | 2 |
| Khabir, A | 2 |
| Meziou, TJ | 2 |
| Akrout, F | 2 |
| Sallemi, T | 1 |
| Turki, H | 2 |
| Zahaf, A | 2 |
| Bouzid, L | 1 |
| Boudawara, T | 1 |
2 trials available for metronidazole and Leishmaniasis, American
| Article | Year |
|---|---|
Randomized, double-blind study on intralesional metronidazole versus intralesional sodium stibogluconate in Leishmania donovani cutaneous leishmaniasis.
Topics: Adult; Antimony Sodium Gluconate; Antiprotozoal Agents; Double-Blind Method; Female; Humans; Injecti | 2019 |
Treatment of cutaneous leishmaniasis by intralesional metronidazole.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administrat | 2004 |
5 other studies available for metronidazole and Leishmaniasis, American
| Article | Year |
|---|---|
Meglumine antimoniate-induced DRESS: original case with a positive skin test.
Topics: Animals; Antiprotozoal Agents; Cryotherapy; Drug Hypersensitivity Syndrome; Eosinophilia; Exanthema; | 2018 |
[Cutaneous leishmaniasis treatment by metronidazole: study of 30 cases].
Topics: Antiprotozoal Agents; Humans; Infant; Leishmaniasis, Cutaneous; Metronidazole; Treatment Outcome | 2009 |
[First cases of imported cutaneous leishmaniasis in Bangui Central African Republic: efficacy of metronidazole].
Topics: Adult; Anti-Infective Agents; Central African Republic; Chad; Humans; Leishmaniasis, Cutaneous; Male | 2003 |
[Clinical and histological study of lupoid cutaneous leishmaniasis (16 cases)].
Topics: Adolescent; Adult; Aged; Antimony; Antiprotozoal Agents; Biopsy; Child; Disease Progression; Female; | 2007 |
[Sporotrichoid cutaneous leishmaniasis in Tunisia: a clinical and histological study].
Topics: Adult; Aged; Anti-Infective Agents; Antiprotozoal Agents; Female; Histiocytes; Humans; Leg Dermatose | 2008 |