metronidazole has been researched along with Ambulation Disorders, Neurologic in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Encefalopathy as a side effect of metronidazole therapy - a case report Neurological symptoms as side effects of pharmacological treatment generally tend to remain underdiagnosed." | 1.46 | [Encefalopathy as a side effect of metronidazole therapy – a case report]. ( Karayianni, M; Laska, AC; von Heijne, A, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Karayianni, M | 1 |
| von Heijne, A | 1 |
| Laska, AC | 1 |
| Farmakiotis, D | 1 |
| Zeluff, B | 1 |
2 other studies available for metronidazole and Ambulation Disorders, Neurologic
| Article | Year |
|---|---|
[Encefalopathy as a side effect of metronidazole therapy – a case report].
Topics: Abscess; Aged; Anti-Infective Agents; Ataxia; Brain Diseases; Dysarthria; Female; Gait Disorders, Ne | 2017 |
IMAGES IN CLINICAL MEDICINE. Metronidazole-Associated Encephalopathy.
Topics: Bacteremia; Brain Diseases; Catheterization, Central Venous; Clostridium Infections; Dysarthria; Fat | 2016 |