metronidazole has been researched along with Abdomen, Acute in 16 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Abdomen, Acute: A clinical syndrome with acute abdominal pain that is severe, localized, and rapid in onset. Acute abdomen may be caused by a variety of disorders, injuries, or diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " difficile diarrhea with metronidazole or vancomycin is highly effective at relieving symptoms." | 4.80 | Treatment of Clostridium difficile-associated diarrhea and colitis. ( Gerding, DN, 2000) |
| "Acute abdomen was the presenting manifestation of pseudomembranous colitis in six men who had previously been treated with antibiotics and presented with abdominal distention, pain, fever, and leukocytosis with absent or mild diarrhea." | 1.28 | Acute abdomen as the first presentation of pseudomembranous colitis. ( Hallstone, AE; Triadafilopoulos, G, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (31.25) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 3 (18.75) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Lam, R | 1 |
| Jamidar, PA | 1 |
| Aslanian, HR | 1 |
| Muniraj, T | 1 |
| Haumann, A | 1 |
| Ongaro, S | 1 |
| Detry, O | 1 |
| Meunier, P | 1 |
| Meurisse, M | 1 |
| Villegas-Betanzo, P | 1 |
| Martínez-Jiménez, MA | 1 |
| Guevara-Torres, L | 1 |
| Quintero-Meza, K | 1 |
| Sánchez-Aguilar, M | 1 |
| Arriaga-Caballero, JE | 1 |
| Limaye, CS | 1 |
| Parikh, FS | 1 |
| Kamath, SA | 1 |
| Lingohr, P | 1 |
| Galetin, T | 1 |
| Rheinwalt, KP | 1 |
| Andiran, N | 1 |
| Acikgoz, ZC | 1 |
| Turkay, S | 1 |
| Andiran, F | 1 |
| de la Iglesia, F | 1 |
| García, JC | 1 |
| Iraburu, M | 1 |
| Armesto, A | 1 |
| Bermúdez, I | 1 |
| Lorenzo-Porto, JA | 1 |
| Honein, K | 1 |
| Yaghi, C | 1 |
| Gerding, DN | 1 |
| Krettek, JE | 1 |
| Goldstein, LI | 1 |
| Busuttil, RW | 1 |
| Olumide, F | 1 |
| Adedeji, A | 1 |
| Adesola, AO | 1 |
| Triadafilopoulos, G | 1 |
| Hallstone, AE | 1 |
| Elechi, EN | 1 |
| Etawo, SU | 1 |
| Zajdowicz, TR | 1 |
| Andåker, L | 1 |
| Höjer, H | 1 |
| Kihlström, E | 1 |
| Lindhagen, J | 1 |
| Kasholm-Tengve, B | 1 |
| Bartholdson, P | 1 |
3 reviews available for metronidazole and Abdomen, Acute
| Article | Year |
|---|---|
[Amebic liver abscess and amebic colitis in a couple].
Topics: Abdomen, Acute; Adult; Drug Therapy, Combination; Dysentery, Amebic; Female; Humans; Liver Abscess, | 1994 |
[Multiple amebic liver abscess].
Topics: Abdomen, Acute; Adult; Antiprotozoal Agents; Fever; Humans; Lebanon; Liver Abscess, Amebic; Magnetic | 1996 |
Treatment of Clostridium difficile-associated diarrhea and colitis.
Topics: Abdomen, Acute; Anti-Bacterial Agents; Antidiarrheals; Clinical Trials as Topic; Clostridioides diff | 2000 |
2 trials available for metronidazole and Abdomen, Acute
| Article | Year |
|---|---|
Stratified duration of prophylactic antimicrobial treatment in emergency abdominal surgery. Metronidazole-fosfomycin vs. metronidazole-gentamicin in 381 patients.
Topics: Abdomen, Acute; Adolescent; Adult; Aged; Appendicitis; Cholecystitis; Clinical Trials as Topic; Drug | 1987 |
Antibiotics in acute abdominal surgery. A clinical trial comparing the combination of ampicillin, mecillinam and metronidazole with cefoxitin alone.
Topics: Abdomen, Acute; Adolescent; Adult; Aged; Amdinocillin; Ampicillin; Cefoxitin; Clinical Trials as Top | 1986 |
11 other studies available for metronidazole and Abdomen, Acute
| Article | Year |
|---|---|
Fitz-Hugh-Curtis Syndrome Presenting as Acute Abdomen.
Topics: Abdomen, Acute; Anti-Bacterial Agents; Cefoxitin; Doxycycline; Exudates and Transudates; Female; Hep | 2020 |
Acute pelvic inflammatory disease as a rare cause of acute small bowel obstruction.
Topics: Abdomen, Acute; Acute Disease; Adult; Anti-Bacterial Agents; Chlamydia Infections; Chlamydia trachom | 2019 |
[Ameboma: possible therapeutic decisions in an amebiasis-endemic region].
Topics: Abdomen, Acute; Adult; Aged; Appendectomy; Cecal Neoplasms; Colectomy; Combined Modality Therapy; Di | 2015 |
An unusual case of acute abdomen -? Is it C. difficile infection.
Topics: Abdomen, Acute; Aged; Anti-Infective Agents; Clostridioides difficile; Clostridium Infections; Human | 2008 |
Acute abdomen due to vaginal impalement.
Topics: Abdomen, Acute; Adolescent; Anti-Infective Agents; Cefazolin; Coitus; Female; Humans; Laparoscopy; M | 2010 |
Blastocystis hominis--an emerging and imitating cause of acute abdomen in children.
Topics: Abdomen, Acute; Animals; Blastocystis hominis; Blastocystis Infections; Child; Communicable Diseases | 2006 |
The symptoms of an amebic abscess of the liver simulating an acute surgical abdomen.
Topics: Abdomen, Acute; Adult; Diagnosis, Differential; Female; Humans; Laparotomy; Liver Abscess, Amebic; M | 1979 |
Metronidazole in acute abdomen. A preliminary report.
Topics: Abdomen, Acute; Adolescent; Adult; Aged; Child; Child, Preschool; Female; Humans; Male; Metronidazol | 1979 |
Acute abdomen as the first presentation of pseudomembranous colitis.
Topics: Abdomen, Acute; Adult; Aged; Anti-Bacterial Agents; Colonoscopy; Diagnosis, Differential; Enterocoli | 1991 |
Management of intraperitoneal rupture of amoebic liver abscess: a 6-year experience with 11 cases in Port Harcourt, Nigeria.
Topics: Abdomen, Acute; Humans; Liver Abscess, Amebic; Metronidazole; Peritoneal Cavity; Rupture, Spontaneou | 1991 |
Amebic liver abscess: the unconsidered and undiagnosed mimic.
Topics: Abdomen, Acute; Adult; Diagnosis, Differential; Fever of Unknown Origin; Humans; Liver Abscess, Ameb | 1986 |