metronidazole has been researched along with Bone Loss, Osteoclastic in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of adjunctive systemic metronidazole was studied in patients with moderate and advanced periodontitis recalcitrant to comprehensive non-surgical treatment." | 9.06 | The effect of systemic metronidazole after non-surgical treatment in moderate and advanced periodontitis in young adults. ( Engström, PE; Frithiof, L; Nedlich, U; Rubin, B; Söder, B; Söder, PO; Wikner, S; Wouters, F, 1990) |
| "The effect of adjunctive systemic metronidazole was studied in patients with moderate and advanced periodontitis recalcitrant to comprehensive non-surgical treatment." | 5.06 | The effect of systemic metronidazole after non-surgical treatment in moderate and advanced periodontitis in young adults. ( Engström, PE; Frithiof, L; Nedlich, U; Rubin, B; Söder, B; Söder, PO; Wikner, S; Wouters, F, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Loesche, WJ | 2 |
| Syed, SA | 1 |
| Morrison, EC | 1 |
| Kerry, GA | 1 |
| Higgins, T | 1 |
| Stoll, J | 1 |
| Nuki, K | 1 |
| Soskolne, WA | 1 |
| Raisz, LG | 1 |
| Kornman, KS | 1 |
| Alander, C | 1 |
| Söder, PO | 1 |
| Frithiof, L | 1 |
| Wikner, S | 1 |
| Wouters, F | 1 |
| Engström, PE | 1 |
| Rubin, B | 1 |
| Nedlich, U | 1 |
| Söder, B | 1 |
| Schmidt, EF | 1 |
| Webber, RL | 1 |
| Ruttimann, UE | 1 |
1 trial available for metronidazole and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
The effect of systemic metronidazole after non-surgical treatment in moderate and advanced periodontitis in young adults.
Topics: Adult; Bone Resorption; Clinical Trials as Topic; Dental Prophylaxis; Dental Scaling; Double-Blind M | 1990 |
3 other studies available for metronidazole and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Metronidazole in periodontitis. I. Clinical and bacteriological results after 15 to 30 weeks.
Topics: Alveolar Process; Bacteria, Anaerobic; Bacteroides; Bone Resorption; Dental Prophylaxis; Dental Scal | 1984 |
Bone resorbing activity of gingiva from beagle dogs following metronidazole and indomethacin therapy.
Topics: Alveolar Process; Animals; Bone Resorption; Dogs; Gingivitis; Indomethacin; Metronidazole; Periodont | 1981 |
Effect of periodontal therapy on alveolar bone as measured by subtraction radiography.
Topics: Alveolar Process; Alveoloplasty; Bone Resorption; Dental Scaling; Equipment Design; Humans; Metronid | 1988 |