metronidazole has been researched along with Cancer of the Tongue in 6 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The results of radiation therapy were compared in 217 patients at advanced stages of cancer of the tongue (131) and fundus of the mouth (86) using split courses of conventional (SCF) and dynamic fractionation (SDF) and SDF combined with metronidazole." | 3.68 | [Probit analysis in assessing the results of radiation therapy of disseminated cancer of the tongue and floor of the mouth]. ( Limarova, IV; Ustinskov, VI; Vorob'ev, IuI, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamamoto, Y | 1 |
| Asai, N | 1 |
| Furuhashi, A | 1 |
| Ono, T | 1 |
| Yamagishi, Y | 1 |
| Mikamo, H | 1 |
| Kazaoka, Y | 1 |
| Vorob'ev, IuI | 2 |
| Limarova, IV | 2 |
| Zykov, AP | 1 |
| Poliakov, PIu | 2 |
| Kiseleva, ES | 1 |
| Kuznetsova, IP | 1 |
| Dar'ialova, SL | 2 |
| Louis, J | 1 |
| Moyer, J | 1 |
| Angelini, J | 1 |
| Kagan, SH | 1 |
| Ustinskov, VI | 1 |
| Karakulov, RK | 1 |
| Pelevina, II | 1 |
| Zazovskiĭ, LM | 1 |
6 other studies available for metronidazole and Cancer of the Tongue
| Article | Year |
|---|---|
Metronidazole-induced encephalopathy caused by hyperbaric oxygen therapy in a patient with mandibular osteomyelitis.
Topics: Aged; Anti-Bacterial Agents; Cerebellar Ataxia; Cerebellar Nuclei; Chemoradiotherapy; Drug Therapy, | 2019 |
[Radiation treatment with metronidazole in patients with oral mucosa cancer in the late stages].
Topics: Aged; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Gamma Rays; Humans; Male; Metroni | 1983 |
[Optimization of methods of radiotherapy of cancer of the tongue, mouth mucosa and oropharynx].
Topics: Adolescent; Adult; Humans; Hyperbaric Oxygenation; Methods; Metronidazole; Middle Aged; Mouth Neopla | 1982 |
Metronidazole oral rinse helps to alleviate odor associated with oral lesions.
Topics: Antitrichomonal Agents; Female; Halitosis; Humans; Metronidazole; Mouthwashes; Tongue Neoplasms | 1997 |
[Probit analysis in assessing the results of radiation therapy of disseminated cancer of the tongue and floor of the mouth].
Topics: Carcinoma, Squamous Cell; Combined Modality Therapy; Dose-Response Relationship, Radiation; Female; | 1990 |
[Use of the indicators of the proliferative activity of tumors of the oropharyngeal area as qualitative prognostic criteria of the radiotherapy].
Topics: Brachytherapy; Carcinoma, Squamous Cell; Humans; Hyperbaric Oxygenation; Metronidazole; Mouth Neopla | 1986 |