metronidazole has been researched along with Gingival Pocket in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Gingival Pocket: An abnormal extension of a gingival sulcus not accompanied by the apical migration of the epithelial attachment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Continued disease progression characterised these patients who, nevertheless, mounted an immune response to the periodontal pathogens but this appeared to be inadequate to stop the disease." | 1.29 | Putative periodontal pathogens, antibody titres and avidities to them in a longitudinal study of patients with resistant periodontitis. ( Holbrook, WP; Kinane, DF; Kitsiou, N; Mooney, J; Sigurdsson, T, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Holbrook, WP | 1 |
| Mooney, J | 1 |
| Sigurdsson, T | 1 |
| Kitsiou, N | 1 |
| Kinane, DF | 1 |
| Pässler, R | 1 |
| Nossek, H | 1 |
2 other studies available for metronidazole and Gingival Pocket
| Article | Year |
|---|---|
Putative periodontal pathogens, antibody titres and avidities to them in a longitudinal study of patients with resistant periodontitis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Antibodies, Bacterial; Antibody Affinity; | 1996 |
[The concentration and duration of the action of metronidazole in the gingival pocket following local application].
Topics: Administration, Topical; Delayed-Action Preparations; Drug Evaluation; Drug Evaluation, Preclinical; | 1989 |