metronidazole has been researched along with Tooth Diseases in 12 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Tooth Diseases: Diseases involving the TEETH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The penicillin-metronidazole combination is well tried antibiotic therapy for the treatment of inflammations of dental origin." | 3.69 | [The role of dalacin C in the management of odontogenic inflammations]. ( Gyenes, V; Sülle, T, 1995) |
| "Caries/pulpitis was the most common diagnosis (n = 222; 31% of cases), of which 48 (21%) were prescribed antibiotics." | 1.42 | Diagnosis and prescribing pattern of antibiotics and painkillers among dentists. ( Lundborg, CS; Marrone, G; Tanwir, F; Tariq, A, 2015) |
| "Amoxicillin still treats these infections effectively." | 1.40 | Microbiological examination and antibiotic sensitivity of infections in the head and neck. Has anything changed? ( Ameerally, PJ; Farmahan, S; Kotecha, R; Sisodia, B; Tuopar, D, 2014) |
| " The antibiotic issued was of standard dosage and the choice of antibiotic prescribed varied depending on the type of infection present." | 1.37 | An outcome audit of three day antimicrobial prescribing for the acute dentoalveolar abscess. ( Ellison, SJ, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (16.67) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chua, SH | 1 |
| Ong, SCL | 1 |
| Liew, YH | 1 |
| Farmahan, S | 2 |
| Tuopar, D | 2 |
| Ameerally, PJ | 2 |
| Kotecha, R | 1 |
| Sisodia, B | 1 |
| Tanwir, F | 1 |
| Marrone, G | 1 |
| Tariq, A | 1 |
| Lundborg, CS | 1 |
| Albuquerque, MT | 1 |
| Ryan, SJ | 1 |
| Münchow, EA | 1 |
| Kamocka, MM | 1 |
| Gregory, RL | 1 |
| Valera, MC | 1 |
| Bottino, MC | 1 |
| Ellison, SJ | 1 |
| Tandon, S | 1 |
| Gyenes, V | 1 |
| Sülle, T | 1 |
| Segelman, AE | 1 |
| Kuriyama, T | 1 |
| Karasawa, T | 1 |
| Nakagawa, K | 1 |
| Yamamoto, E | 1 |
| Nakamura, S | 1 |
| Chomarat, M | 1 |
| Dubost, J | 1 |
| Kalfon, F | 1 |
| Cros, P | 1 |
| Freidel, M | 1 |
| Jacquemard, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Use of Single Dose vs Short-Term Peri-Operative Cefazolin in the Prevention of Surgical Site Infection Following Orthognathic Surgery[NCT05852158] | Phase 4 | 400 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metronidazole and Tooth Diseases
| Article | Year |
|---|---|
Review of metronidazole use in dentistry.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Clinical Trials as Topic; Humans; Metronidazol | 1997 |
1 trial available for metronidazole and Tooth Diseases
| Article | Year |
|---|---|
[Randomized study of amoxicillin-clavulanic acid versus amoxicillin-metronidazole combinations in pyogenic infections of dental origin].
Topics: Adolescent; Adult; Amoxicillin; Anti-Bacterial Agents; Bacterial Infections; Clavulanic Acid; Clavul | 1991 |
10 other studies available for metronidazole and Tooth Diseases
| Article | Year |
|---|---|
Variant of Lemierre's syndrome with internal jugular vein aneurysm.
Topics: Aneurysm; Anti-Bacterial Agents; Anticoagulants; Ceftriaxone; Enoxaparin; Female; Humans; Jugular Ve | 2017 |
The clinical relevance of microbiology specimens in head and neck space infections of odontogenic origin.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amoxicillin; Amoxicillin-Potassium Clavulanate Combinati | 2014 |
Microbiological examination and antibiotic sensitivity of infections in the head and neck. Has anything changed?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amoxicillin; Bacteria; Bacteria, Anaerobic; Child; Child | 2014 |
Diagnosis and prescribing pattern of antibiotics and painkillers among dentists.
Topics: Adolescent; Adult; Amoxicillin; Analgesics; Anti-Bacterial Agents; Child; Child, Preschool; Cross-Se | 2015 |
Antimicrobial Effects of Novel Triple Antibiotic Paste-Mimic Scaffolds on Actinomyces naeslundii Biofilm.
Topics: Actinomyces; Actinomycosis; Anti-Bacterial Agents; Biofilms; Chromatography, High Pressure Liquid; C | 2015 |
An outcome audit of three day antimicrobial prescribing for the acute dentoalveolar abscess.
Topics: Abscess; Acute Disease; Adult; Amoxicillin; Anti-Bacterial Agents; Clindamycin; Dental Audit; Draina | 2011 |
Clinical experience with metronidazole in anaerobic oro-dental infections.
Topics: Adolescent; Adult; Anaerobiosis; Bacterial Infections; Child; Female; Humans; Male; Metronidazole; M | 1980 |
[The role of dalacin C in the management of odontogenic inflammations].
Topics: Bacteria, Aerobic; Bacteria, Anaerobic; Clindamycin; Drug Resistance, Microbial; Humans; Inflammatio | 1995 |
Incidence of beta-lactamase production and antimicrobial susceptibility of anaerobic gram-negative rods isolated from pus specimens of orofacial odontogenic infections.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ampicillin Resistance; Anti-Bacterial Agents; Bacteroida | 2001 |
[Value of the synergic association metronidazole-spiramycin in current dental practice. Report of 63 cases].
Topics: Adolescent; Adult; Aged; Child; Dental Pulp Diseases; Drug Synergism; Female; Humans; Leucomycins; M | 1971 |