metronidazole has been researched along with Pyoderma Gangrenosum in 5 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Pyoderma Gangrenosum: An idiopathic, rapidly evolving, and severely debilitating disease occurring most commonly in association with chronic ulcerative colitis. It is characterized by the presence of boggy, purplish ulcers with undermined borders, appearing mostly on the legs. The majority of cases are in people between 40 and 60 years old. Its etiology is unknown.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyoderma gangrenosum is characteristically associated with inflammatory bowel disease." | 2.72 | Multifocal pyoderma gangrenosum secondary to subclinical diverticulitis: case report and brief literature review. ( Álvarez-Salafranca, M; Bularca, EA; Espuelas-Monge, M; Lapeña-Casado, A; Rivera-Fuertes, I; Soria-Navarro, J, 2021) |
| "Although infrequent, metastatic Crohn's disease should be suspected in cases of recalcitrant ulcerative conditions, even in the absence of intestinal disease." | 1.33 | Metastatic Crohn's disease mimicking genital pyoderma gangrenosum in an HIV patient. ( Avilés-Izquierdo, JA; Lázaro-Ochaita, P; Longo-Imedio, I; Suárez-Fernández, R, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Álvarez-Salafranca, M | 1 |
| Bularca, EA | 1 |
| Rivera-Fuertes, I | 1 |
| Lapeña-Casado, A | 1 |
| Soria-Navarro, J | 1 |
| Espuelas-Monge, M | 1 |
| Little, K | 1 |
| Paramkusam, G | 1 |
| Meduri, V | 1 |
| Gangeshetty, N | 1 |
| Avilés-Izquierdo, JA | 1 |
| Suárez-Fernández, R | 1 |
| Lázaro-Ochaita, P | 1 |
| Longo-Imedio, I | 1 |
| Farrell, AM | 1 |
| Black, MM | 1 |
| Bracka, A | 1 |
| Bunker, CB | 1 |
3 reviews available for metronidazole and Pyoderma Gangrenosum
| Article | Year |
|---|---|
Multifocal pyoderma gangrenosum secondary to subclinical diverticulitis: case report and brief literature review.
Topics: Aged, 80 and over; Anti-Bacterial Agents; Clindamycin; Diagnosis, Differential; Diverticulitis, Colo | 2021 |
Pyoderma gangrenosum with oral involvement - case report and review of the literature.
Topics: Adult; Anti-Infective Agents; Chlorhexidine; Dapsone; Drug Therapy, Combination; Female; Glucocortic | 2010 |
Pyoderma gangrenosum of the penis.
Topics: Adult; Anti-Inflammatory Agents; Antitrichomonal Agents; Combined Modality Therapy; Drug Therapy, Co | 1998 |
2 other studies available for metronidazole and Pyoderma Gangrenosum
| Article | Year |
|---|---|
What is causing this patient's multiple skin abscesses?
Topics: Abscess; Adolescent; Colitis, Ulcerative; Cyclosporine; Dermatologic Agents; Female; Gastrointestina | 2018 |
Metastatic Crohn's disease mimicking genital pyoderma gangrenosum in an HIV patient.
Topics: Adult; Anti-Infective Agents; Anti-Inflammatory Agents; Crohn Disease; Diagnosis, Differential; Gran | 2005 |