metronidazole has been researched along with Invasiveness, Neoplasm in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole (MNZ) is a common antibiotic that exerts disulfiram-like effects when taken together with alcohol." | 5.48 | Combined Gemcitabine and Metronidazole Is a Promising Therapeutic Strategy for Cancer Stem-like Cholangiocarcinoma. ( Kawabe, K; Kawamoto, M; Koya, N; Morisaki, T; Nakagawa, S; Nakamura, M; Onishi, H; Tanaka, H; Umebayashi, M, 2018) |
| "Biofilms on oral squamous cell carcinomas are enriched with anaerobic periodontal pathogens, including F." | 2.72 | Fusobacterium nucleatum and oral cancer: a critical review. ( Craig, SG; James, JA; Linden, GJ; Lundy, FT; McIlvanna, E, 2021) |
| "Metronidazole (MNZ) is a common antibiotic that exerts disulfiram-like effects when taken together with alcohol." | 1.48 | Combined Gemcitabine and Metronidazole Is a Promising Therapeutic Strategy for Cancer Stem-like Cholangiocarcinoma. ( Kawabe, K; Kawamoto, M; Koya, N; Morisaki, T; Nakagawa, S; Nakamura, M; Onishi, H; Tanaka, H; Umebayashi, M, 2018) |
| "An increased incidence of colonic cancer is associated with chronic inflammatory bowel disease." | 1.28 | The effect of therapeutic drugs used in inflammatory bowel disease on the incidence and growth of colonic cancer in the dimethylhydrazine rat model. ( Crouch, R; Davis, AE; Patterson, F, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| McIlvanna, E | 1 |
| Linden, GJ | 1 |
| Craig, SG | 1 |
| Lundy, FT | 1 |
| James, JA | 1 |
| Kawamoto, M | 1 |
| Umebayashi, M | 1 |
| Tanaka, H | 1 |
| Koya, N | 1 |
| Nakagawa, S | 1 |
| Kawabe, K | 1 |
| Onishi, H | 1 |
| Nakamura, M | 1 |
| Morisaki, T | 1 |
| Clark, J | 1 |
| Davis, AE | 1 |
| Patterson, F | 1 |
| Crouch, R | 1 |
1 review available for metronidazole and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Fusobacterium nucleatum and oral cancer: a critical review.
Topics: Animals; Anti-Bacterial Agents; Bacterial Adhesion; Biofilms; Cell Movement; Cell Proliferation; Col | 2021 |
3 other studies available for metronidazole and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Combined Gemcitabine and Metronidazole Is a Promising Therapeutic Strategy for Cancer Stem-like Cholangiocarcinoma.
Topics: Aldehyde Dehydrogenase; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Biomark | 2018 |
Metronidazole gel in managing malodorous fungating wounds.
Topics: Bacteria, Anaerobic; Bacterial Infections; Clinical Trials as Topic; Gels; Humans; Metronidazole; Ne | 2002 |
The effect of therapeutic drugs used in inflammatory bowel disease on the incidence and growth of colonic cancer in the dimethylhydrazine rat model.
Topics: Adenocarcinoma; Aminosalicylic Acids; Animals; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazin | 1992 |