metronidazole has been researched along with Nervous System Disorders in 16 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Anecdotal reports suggest that metronidazole may have disease modifying activity in the treatment of rheumatoid arthritis." | 9.07 | Double blind, placebo controlled study of metronidazole as a disease modifying agent in the treatment of rheumatoid arthritis. ( Capell, HA; Hunter, JA; Marshall, DA, 1992) |
| "Anecdotal reports suggest that metronidazole may have disease modifying activity in the treatment of rheumatoid arthritis." | 5.07 | Double blind, placebo controlled study of metronidazole as a disease modifying agent in the treatment of rheumatoid arthritis. ( Capell, HA; Hunter, JA; Marshall, DA, 1992) |
| "Metronidazole-induced encephalopathy should be considered in patients presenting with neurological symptoms in relation to newly initiated or prolonged metronidazole treatment." | 2.66 | Metronidazole-induced encephalopathy: a systematic review. ( Amin, FM; Karlsson, WK; Lindelof, M; Sørensen, CG, 2020) |
| " In long-term administration of metronidazole 10-50% of the patients develop a sensory polyneuropathy with a total dosis of at least 22." | 2.38 | [Neurologic concomitant diseases in Crohn disease]. ( Neundörfer, B, 1992) |
| "Linezolid was selected as a first-line antimicrobial drug." | 1.39 | Otogenic cerebellar abscess by Enterococcus avium, a very rare infectious agent. ( Escribano, JA; Lozano, J; Rivin, E; Solivera, J; Vidal, E, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (43.75) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 4 (25.00) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Sørensen, CG | 1 |
| Karlsson, WK | 1 |
| Amin, FM | 1 |
| Lindelof, M | 1 |
| Escribano, JA | 1 |
| Solivera, J | 1 |
| Vidal, E | 1 |
| Rivin, E | 1 |
| Lozano, J | 1 |
| Sahaya, K | 1 |
| Sarwal, A | 1 |
| Lanigar, S | 1 |
| Miller, DC | 1 |
| Song, HC | 1 |
| Bom, HS | 1 |
| Cho, KH | 1 |
| Kim, BC | 1 |
| Seo, JJ | 1 |
| Kim, CG | 1 |
| Yang, DJ | 1 |
| Kim, EE | 1 |
| Rustscheff, S | 1 |
| Hulten, S | 1 |
| Englert, C | 1 |
| Aebert, H | 1 |
| Lenhart, M | 1 |
| Solleder, A | 1 |
| Nerlich, M | 1 |
| Neumann, C | 1 |
| Dubois, A | 1 |
| Raffanel, C | 1 |
| Pignodel, C | 1 |
| Janbon, C | 1 |
| Marty-Double, C | 1 |
| Balmes, P | 1 |
| Snavely, SR | 1 |
| Hodges, GR | 1 |
| Boman, J | 1 |
| Roblin, PM | 1 |
| Sundström, P | 1 |
| Sandström, M | 1 |
| Hammerschlag, MR | 1 |
| Willson, RL | 1 |
| Dainer, MJ | 1 |
| Neundörfer, B | 1 |
| Marshall, DA | 1 |
| Hunter, JA | 1 |
| Capell, HA | 1 |
| Alston, TA | 1 |
3 reviews available for metronidazole and Nervous System Disorders
| Article | Year |
|---|---|
Metronidazole-induced encephalopathy: a systematic review.
Topics: Anti-Bacterial Agents; Brain Diseases; Humans; Metronidazole; Nervous System Diseases | 2020 |
The neurotoxicity of antibacterial agents.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Central Nervous System Disea | 1984 |
[Neurologic concomitant diseases in Crohn disease].
Topics: Crohn Disease; Humans; Metronidazole; Nervous System Diseases; Neurologic Examination | 1992 |
2 trials available for metronidazole and Nervous System Disorders
| Article | Year |
|---|---|
Prognostication of recovery in patients with acute ischemic stroke through the use of brain SPECT with Technetium-99m--labeled metronidazole.
Topics: Acute Disease; Aged; Brain; Brain Ischemia; Cysteine; Diffusion Magnetic Resonance Imaging; Female; | 2003 |
Double blind, placebo controlled study of metronidazole as a disease modifying agent in the treatment of rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Male; Metronidazole; Middle | 1992 |
11 other studies available for metronidazole and Nervous System Disorders
| Article | Year |
|---|---|
Otogenic cerebellar abscess by Enterococcus avium, a very rare infectious agent.
Topics: Acetamides; Anti-Bacterial Agents; Brain Abscess; Cerebellar Diseases; Ciprofloxacin; Enterococcus; | 2013 |
Coma in a 34-year-old with progressive changes on neuroimaging.
Topics: Adult; Coma; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Metronidazole; Nervous | 2010 |
An unexpected and severe neurological disorder with permanent disability acquired during short-course treatment with metronidazole.
Topics: Chronic Disease; Disability Evaluation; Female; Follow-Up Studies; Humans; Metronidazole; Middle Age | 2003 |
Thoracic spondylitis from a mycotic (Streptococcus pneumoniae) aortic aneurysm: a case report.
Topics: Aneurysm, Infected; Anti-Bacterial Agents; Aortic Aneurysm, Thoracic; Blood Vessel Prosthesis Implan | 2004 |
[Acute cerebellar syndrome associated with sensitive neuropathy in a patient treated with metronidazole].
Topics: Cerebellar Diseases; Humans; Male; Metronidazole; Middle Aged; Nervous System Diseases; Sensation; S | 1983 |
Failure to detect Chlamydia pneumoniae in the central nervous system of patients with MS.
Topics: Adult; Aged; Anti-Bacterial Agents; Antibodies, Bacterial; Cerebrospinal Fluid; Chlamydophila pneumo | 2000 |
Letter: Metronidazole and tissue zinc/iron ratio in cancer therapy.
Topics: Humans; Iron; Metronidazole; Neoplasms; Nervous System Diseases; Skin Diseases; Zinc | 1976 |
Untoward reaction to Flagyl (metronidazole)
Topics: Adult; Female; Humans; Metronidazole; Nervous System Diseases; Trichomonas Vaginitis | 1979 |
Letter: Metronidazole as a radiosensitizer.
Topics: Metronidazole; Neoplasms; Nervous System Diseases; Radiation-Sensitizing Agents | 1976 |
[Polyneuropathy after long term treatment with metronidazole].
Topics: Adult; Female; Humans; Male; Metronidazole; Nervous System Diseases | 1985 |
Neurotoxicity of metronidazole.
Topics: Antimetabolites; Humans; Metronidazole; Nervous System Diseases; Thiamine | 1985 |