metronidazole has been researched along with Squamous Cell Carcinoma of Head and Neck in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Squamous Cell Carcinoma of Head and Neck: The most common type of head and neck carcinoma that originates from cells on the surface of the NASAL CAVITY; MOUTH; PARANASAL SINUSES, SALIVARY GLANDS, and LARYNX. Mutations in TNFRSF10B, PTEN, and ING1 genes are associated with this cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Biofilms on oral squamous cell carcinomas are enriched with anaerobic periodontal pathogens, including F." | 2.72 | Fusobacterium nucleatum and oral cancer: a critical review. ( Craig, SG; James, JA; Linden, GJ; Lundy, FT; McIlvanna, E, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| McIlvanna, E | 1 |
| Linden, GJ | 1 |
| Craig, SG | 1 |
| Lundy, FT | 1 |
| James, JA | 1 |
| Yamamoto, Y | 1 |
| Asai, N | 1 |
| Furuhashi, A | 1 |
| Ono, T | 1 |
| Yamagishi, Y | 1 |
| Mikamo, H | 1 |
| Kazaoka, Y | 1 |
1 review available for metronidazole and Squamous Cell Carcinoma of Head and Neck
| Article | Year |
|---|---|
Fusobacterium nucleatum and oral cancer: a critical review.
Topics: Animals; Anti-Bacterial Agents; Bacterial Adhesion; Biofilms; Cell Movement; Cell Proliferation; Col | 2021 |
1 other study available for metronidazole and Squamous Cell Carcinoma of Head and Neck
| Article | Year |
|---|---|
Metronidazole-induced encephalopathy caused by hyperbaric oxygen therapy in a patient with mandibular osteomyelitis.
Topics: Aged; Anti-Bacterial Agents; Cerebellar Ataxia; Cerebellar Nuclei; Chemoradiotherapy; Drug Therapy, | 2019 |