An EC 3.4.23.* (aspartic endopeptidase) inhibitor that interferes with the activity of renin (EC 3.4.23.15).
ChEBI ID: 166822
| Member | Definition | Class |
|---|---|---|
| ro 42-5892 | An L-histidine derivative that is L-histidine in which one of the amino hydrogens is replaced by a (2S)-2-[(2-methylpropane-2-sulfonyl)methyl]-3-phenylpropanoyl group and the carboxy group is replaced by a [(2S,3R,4S)-1-cyclohexyl-4-cyclopropyl-3,4-dihydroxybutan-2-yl]amino group. It is a renin inhibitor which was under development for the treatment of hypertension (now discontinued). | remikiren |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 49 (72.06) | 18.2507 |
| 2000's | 11 (16.18) | 29.6817 |
| 2010's | 6 (8.82) | 24.3611 |
| 2020's | 2 (2.94) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 19 (27.54%) | 5.53% |
| Reviews | 9 (13.04%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 41 (59.42%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Renin | Homo sapiens (human) | IC50 | 0.0000 | 1 | 2 |
| Renin | Homo sapiens (human) | Ki | 0.0007 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Renin | Homo sapiens (human) | Kd | 0.0001 | 1 | 1 |